Consensus on infertility treatment related to polycystic ovary syndrome

Thessaloniki,; Greece,

doi:10.1016/j.fertnstert.2007.09.041

Cited by 620 publications

(93 citation statements)

References 161 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For infertile, anovulatory PCOS patients, clomiphene citrate (CC) is typically the first-line therapy (4). Several factors have been reported to predict fertility success after CC stimulation, including body mass index (BMI) and Hashimoto's thyroiditis, among others (5,6).…”

Section: Introductionmentioning

confidence: 99%

Parameters for calcium metabolism in women with polycystic ovary syndrome who undergo clomiphene citrate stimulation: a prospective cohort study

Ott

Wattar

Kurz

et al. 2012

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: To evaluate whether parameters for calcium metabolism were associated with characteristics of polycystic ovary syndrome (PCOS). Design: A prospective cohort study. Methods: Ninety-one anovulatory, infertile women with PCOS patients underwent clomiphene citrate (CC) stimulation. Main outcome measures were parathyroid hormone (PTH); 25-hydroxyvitamin D3 (25OHD3); serum levels of calcium, phosphorus, magnesium, albumin, and total protein; the serum calcium-phosphorus product; LH; FSH; sexual hormone binding globulin; testosterone; and androstenedione. Results: PTH correlated inversely with serum calcium (rZK0.235; PZ0.004) and 25OHD3 (rZK0.664; P!0.001), whereas positive correlations were found between PTH and body mass index (BMI; rZ0.270; PZ0.010) and between PTH and testosterone (rZ0.347; PZ0.001). After stimulation with 50 mg CC, 57.1% (52/91) developed a follicle, whereas 26.4% (24/91) became pregnant. In a multivariate model to predict both follicle development and pregnancy, BMI and 25OHD3 deficiency were significant predictive parameters. Conclusions: 25OHD3 deficiency was an independent predictive parameter of CC stimulation outcome, in terms of follicle development and pregnancy. Our results suggest a substantial role of vitamin D in PCOS and infertility treatment in these patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Parameters for calcium metabolism in women with polycystic ovary syndrome who undergo clomiphene citrate stimulation: a prospective cohort study

Ott

Wattar

Kurz

et al. 2012

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Several research groups have observed a higher pregnancy rate with gonadotropin therapy as compared to oral ovulation inducing agents in women failing to conceive with CC/IUI [4][5][6]. Recently, a consensus has been reached on the use of either exogenous gonadotropins or laparoscopic ovarian surgery in CC-resistant women as a second-line of intervention [7]. Gonadotropins (FSH/hMG) used in combination with CC decrease the dose required for optimum stimulation and make it more cost-effective in women who fail to respond to CC treatment [8].…”

Section: Introductionmentioning

confidence: 99%

Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial

Ganesh

Goswami

Chattopadhyay

et al. 2009

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose Letrozole, though reported to be an effective ovulation inducing agent, warrants larger randomized trials. The purpose of this study is to compare the efficacy of letrozole with that of rFSH and clomiphene citrate(CC)/rFSH for ovarian stimulation in IUI cycles. Methods Randomized, prospective, single-blinded clinical trial. 1387 PCOS women after CC failure were randomized into three groups: Group A received letrozole, Group B received CC with two doses rFSH and Group C received continuous rFSH day 2 onwards until hCG injection. Results Group A, B and C had an ovulation rate of 79.30%, 56.95% and 89.89% and cycle cancellation rate of 20.70%, 43.05% and 10.11%, respectively. Pregnancy rates in Group A, B and C were 23.39%, 14.35% and 17.92%, while the miscarriage rates were 13.80%, 16.67% and 14.52%, respectively. Conclusion Letrozole appears to be a suitable ovulation inducing agent in PCOS women with CC failure and is found to be most effective when baseline estradiol level >60 pg/ml.

show abstract

“…Исследования R. Hart et al (2015) показали, что бесплодие у пациенток с СПЯ встречается в 10 раз чаще пo сравнению с популяционными значениями [34]. В соот-ветствии со всеми последними рекомендация-ми препаратом первой линии все еще остается кломифена цитрат (КЦ) -нестероидный анта-гонист рецепторов эстрогенов [35]. Механизм действия КЦ заключается в блокаде рецепторов эстрогенов в гипоталамусе, что ведет к усилен- …”

Section: лечение пациенток с синдромом поликистозных яичниковunclassified

“…Хирургический метод также относится к те-рапии второй линии с целью достижения бе-ременности у женщин с СПЯ [35]. Первые по-пытки хирургического лечения СПЯ относятся к 1864 г., когда S.M.…”

unclassified

Treatment of infertility in women with polycystic ovary syndrome using assisted reproductive technology

et al. 2017

View full text Add to dashboard Cite

show abstract

Consensus on infertility treatment related to polycystic ovary syndrome

Cited by 620 publications

References 161 publications

Parameters for calcium metabolism in women with polycystic ovary syndrome who undergo clomiphene citrate stimulation: a prospective cohort study

Parameters for calcium metabolism in women with polycystic ovary syndrome who undergo clomiphene citrate stimulation: a prospective cohort study

Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial

Treatment of infertility in women with polycystic ovary syndrome using assisted reproductive technology

Contact Info

Product

Resources

About