The Role of Visinin-Like Protein-1 in the Pathophysiology of Alzheimer’s Disease

Groblewska, Magdalena; Muszyński, Paweł; Wojtulewska-Supron, Aleksandra; Kulczyńska-Przybik, Agnieszka; Mroczko, Barbara

doi:10.3233/jad-150060

Cited by 39 publications

(36 citation statements)

References 108 publications

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“…As a neuronal calcium-sensor protein, 5,6 VILIP-1 has been suggested as a marker for neuron injury in brain injury models. 7,34,35 Previous studies indicated that the level of CSF VILIP-1 was associated with the concentrations of CSFtau and P-tau, 6,8,9 supporting its utilization as a neurodegeneration marker. In addition, some studies revealed that CSF VILIP-1 could diagnostically discriminate AD from other dementias.…”

Section: Discussionmentioning

confidence: 94%

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<p>APOE ϵ4 Allele Is Associated with Elevated Levels of CSF VILIP-1 in Preclinical Alzheimer’s Disease</p>

Wang

Zhang

Wang³

et al. 2020

NDT

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Objectives: Cerebrospinal fluid (CSF) visinin-like protein 1 (VILIP-1) has been suggested as a biomarker for neuron injury, which has been shown to have a important diagnostic value in symptomatic Alzheimer's disease (AD). The study purpose is investigating potential effects of apolipoprotein E (APOE) ε4 on CSF VILIP-1 levels among the preclinical AD. Methods: A total of 110 subjects (including 43 APOE ε4 carriers and 67 ε4 non-carriers) were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) in the present study. Results: The results showed that VILIP-1 concentrations in the CSF were statistically significantly increased in APOE ε4 carriers in comparison with non-carriers. Increased CSF VILIP-1 level was positively associated with the concentrations of both CSF-tau and P-tau levels. Conclusions: Our findings suggested that APOE ε4 might affect CSF VILIP-1 level in preclinical AD, indicating an important role of APOE ε4 in neuron injury leading to AD.

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Section: Discussionmentioning

confidence: 94%

“…As a neuronal calcium-sensor protein, 5,6 visinin-like protein 1 (VILIP-1) has been suggested as a biomarker of neuron injury. 7 Previous studies have shown that cerebrospinal fluid (CSF) VILIP-1 was significantly associated with AD, indicating that VILIP-1 may be a potential biomarker for neurodegeneration.…”

Section: Introductionmentioning

confidence: 99%

<p>APOE ϵ4 Allele Is Associated with Elevated Levels of CSF VILIP-1 in Preclinical Alzheimer’s Disease</p>

Wang

Zhang

Wang³

et al. 2020

NDT

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“…The disorder of calcium homeostasis is considered to be one of the main characteristics of the pathophysiology of AD, and the pathogenesis of AD is closely related to the calcium signaling pathway [ 27 ]. Therefore, VILIP-1, as a neuronal calcium sensor protein, might have a connection to the etiology of AD [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease

Zhang

Therriault

et al. 2018

Transl Neurodegener

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BackgroundVisinin-like protein-1 (VILIP-1) and chitinase-3-like protein 1 (CHI3L1 or YKL-40) in cerebrospinal fluid (CSF) are newly discovered markers indicating neuronal damage and microglial activation, respectively. Phosphorylated tau (p-tau) reflects the neuropathology of Alzheimer’s disease (AD) and is useful as diagnostic markers for AD. However, it is unknown whether these biomarkers have similar or complementary information in AD.MethodsWe stratified 121 participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database into cognitively normal (CN), stable mild cognitive impairment (sMCI), progressive MCI (pMCI), and dementia due to AD. Analysis of covariance (ANOVA) and chi-square analyses, Spearman correlation, and logistic regression models were performed to test the demographic, associations between biomarkers, and diagnostic accuracies, respectively. Linear mixed-effects models were used to evaluate the effects of CSF amyloid-β (Aβ) on above biomarkers within diagnostic groups, the combination of diagnostic group and Aβ status as predictor, and CSF biomarkers as predictors of AD features, including cognition measured by Mini–Mental State Examination (MMSE) and brain structure and white matter hyperintensity (WMH) measured by magnetic resonance imaging (MRI).ResultsP-tau, VILIP-1, and YKL-40 were all predictors of AD diagnosis, but combinations of biomarkers did not improve the diagnostic accuracy (AUC 0.924 for p-tau, VILIP-1, and YKL-40) compared to p-tau (AUC 0.922). P-tau and VILIP-1 were highly correlated (r = 0.639, p < 0.001) and strongly associated with Aβ pathology across clinical stages of AD, while YKL-40 was correlated with Aβ pathology in CN and AD groups. VILIP-1 was associated with acceleration of cognitive decline, hippocampal atrophy, and expansion of ventricles in longitudinal analyses. YKL-40 was associated with hippocampal atrophy at baseline and follow-up, while p-tau was only associated with worsening WMH at baseline.ConclusionsCSF levels of p-tau, VILIP-1, and YKL-40 may have utility for discriminating between cognitively normal subjects and patients with AD. Increased levels of both VILIP-1 and YKL-40 may be associated with disease degeneration. These CSF biomarkers should be considered for future assessment in the characterization of the natural history of AD.Electronic supplementary materialThe online version of this article (10.1186/s40035-018-0127-7) contains supplementary material, which is available to authorized users.

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“…As a result of aggregation, functional levels of VSNL1 are decreased, possibly providing a second mechanism to keep GC inactive besides calcium levels. Furthermore, VSNL1 aggregates are found in amyotrophic lateral sclerosis (ALS)-associated deposits, linking them to neuronal impairment [75][76][77][78][79].…”

Section: Functional Redox-dependent Aggregationmentioning

confidence: 99%

Cross-talk between redox signalling and protein aggregation

Dam

Dansen

2020

Biochemical Society Transactions

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It is well established that both an increase in reactive oxygen species (ROS: i.e. O2•−, H2O2 and OH•), as well as protein aggregation, accompany ageing and proteinopathies such as Parkinson's and Alzheimer's disease. However, it is far from clear whether there is a causal relation between the two. This review describes how protein aggregation can be affected both by redox signalling (downstream of H2O2), as well as by ROS-induced damage, and aims to give an overview of the current knowledge of how redox signalling affects protein aggregation and vice versa. Redox signalling has been shown to play roles in almost every step of protein aggregation and amyloid formation, from aggregation initiation to the rapid oligomerization of large amyloids, which tend to be less toxic than oligomeric prefibrillar aggregates. We explore the hypothesis that age-associated elevated ROS production could be part of a redox signalling-dependent-stress response in an attempt to curb protein aggregation and minimize toxicity.

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The Role of Visinin-Like Protein-1 in the Pathophysiology of Alzheimer’s Disease

Cited by 39 publications

References 108 publications

<p>APOE ϵ4 Allele Is Associated with Elevated Levels of CSF VILIP-1 in Preclinical Alzheimer’s Disease</p>

<p>APOE ϵ4 Allele Is Associated with Elevated Levels of CSF VILIP-1 in Preclinical Alzheimer’s Disease</p>

Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease

Cross-talk between redox signalling and protein aggregation

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