The Role of Transient Mucosal Ischemia in Acetic Acid-Induced Colitis in the Rat

Morphologic and morphometric analyses of acetic acid‐induced colitis in rats after treatment with enemas from Myracrodruon urundeuva Fr. All. (Aroeira do Sertão)

“…It is known (Makino et al, 1998) that acetic acid-induced colonic lesions in rats cause epithelial cell necrosis, increased mucin production and increased neutrophil infiltration. This is a useful model for studying events that occur at the time of inflammation and repair, and although being a reproducible experimental model pathologically resembling human ulcerative colitis (Fabia et al, 1992;Fabia et al, 1996), it has significant limitations in understanding the events that initiate inflammation in the human pathological condition (Yamada et al, 1991b). In Northeast Brazil, Myracrodruon urundeuva is popularly used as antiinflammatory agent in the treatment of gynaecological and gastrointestinal problems.…”

Phycocyanin liposomes for topical anti-inflammatory activity: in-vitro in-vivo studies

“…In these experiments we compared the drug activity as a function of Oed I% and myeloperoxidase reduction (MPO I%). The level of MPO activity is directly proportional to the neutrophil concentration in the inflamed tissue 39 . In this work, we used MPO activity in inflamed ear tissue as a quantitative and sensitive assay of drug anti‐inflammatory efficiency.…”

Venular Constriction of Submucosal Arterioles Induced by Dextran Sodium Sulfate

“…Hatoum et al3 have provided novel data from human submucosal arterioles dissected from patients undergoing clinical bowel operations, in which arterioles from chronically inflamed patients with IBD showed significantly attenuated endothelium‐dependent dilation induced by acetylcholine. Additionally, the acetic acid‐induced model of experimental colitis is thought to depend on a hypoperfusion period and can be mimicked by an appropriately timed model of ischemia‐reperfusion 4. Radiological images from trinitrobenzene sulfonic acid (TNBS)‐induced colitis in the rat show arteriolar narrowing and regions of poor perfusion in the intestine 5…”