Morphologic and morphometric analyses of acetic acid‐induced colitis in rats after treatment with enemas from Myracrodruon urundeuva Fr. All. (Aroeira do Sertão)

Abstract

The present work showed the effects of Myracrodruon urundeuva Fr. All., popularly known as 'aroeira' (AE), in the form of enemas prepared from the stem bark, on several morphologic and morphometric parameters after acetic acid-induced colitis in rats. Enemas from 5-ASA were used as standard while the vehicle, carboxymethylcellulose, was used as a control. The results of the morphological evaluation showed that on day 1 acetic acid produced significantly more necrosis in the groups treated with AE (10% and 20%) or 5-ASA than the controls. However, on day 60, there were more caliciform and absorptive cells in the treated groups compared with the controls. A significantly higher number of eosinophil and mononuclear cells and also collagen deposition in the controls compared with the treated groups were observed on day 60. However, a higher number of polymorphonuclear cells was detected on day 60 only in the AE treated group but not in the 5-ASA group. These data indicate that animals treated with AE or 5-ASA showed complete epithelial tissue regeneration, while in the controls chronic inflammatory exudate persisted and tissue regeneration occurred through fibrosis.

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

“…In this sense, Rodrigues et al (2002) showed the effects of M. urundeuva, in the form of enemas prepared from the stem bark, on several morphologic and morphometric parameters after acetic acid-induced colitis in rats. Results evidenced that animals treated with M. urundeuva showed complete epithelial tissue regeneration, while in the controls chronic inflammatory exudate persisted and tissue regeneration occurred through fibrosis.…”

Armazenamento de sementes de Myracrodruon urundeuva Fr. All. em diferentes embalagens e ambientes

“…Pesquisas com vistas à avaliação científica da eficácia terapêutica têm mostrado evidente efeito antiinflamatório, cicatrizante, antiulcerogênico, antihistamínico, antibradicinina e analgésico (Viana et al, 1997;Rodrigues et al, 2002). Devido ao uso intenso e predatório, a M. urundeuva foi incluída na lista oficial do IBAMA como espécie ameaçada de extinção, na categoria vulnerável (IBAMA, 1992).…”

Viability of Human Gingival Fibroblast (FGH) Treated with Ethanolic "Aroeira" Extract (Myracrodruon urundeuva Allemão)

“…The leaves, seeds, twigs, and stems of the "aroeira" (Myracrodruon urundeuva), a tree that is widely present throughout Brazil, have been studied because of their antifungal, anti-adherent, and antimicrobial activities (Machado and Oliveira 2014). Among "aroeira" extract properties, described in the literature with in vivo models, the following benefits can be pointed out: healing effects (Nunes Jr. et al 2008); anti-inflammatory effects (Rodrigues et al 2002;Souza et al 2007), and antiulcerative effects (Souza et al 2007). Another extract property of "aroeira" (Machado and Oliveira 2014) is its antimicrobial effect.…”