The Role of Tomato Lycopene in Cancer Prevention

Levy, Joseph; Walfisch, Shlomo; Atzmon, Andrea; Hirsch, Keren; Khanin, Marina; Linnewiel, Karin; Morag, Yael; Salman, Hagar; Veprik, Anna; Danilenko, Michael; Sharoni, Yoav

doi:10.1007/978-90-481-9800-9_3

Cited by 3 publications

(2 citation statements)

References 97 publications

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“… 109 , 110 Indeed, experimental studies provided evidence that lycopene may act as an anti-inflammatory agent against certain types of disease, including those of the liver, lung, colon and prostate. 98 , 111 , 112 Patients with fatty liver have significantly reduced plasma lycopene. 113 …”

Section: Dietary Tomato Rich In Lycopene Inhibits Ald By Suppressing mentioning

confidence: 99%

“…Besides, lycopene promoted the pro-apoptotic genes expression including caspase 3, 9 and p53 108 , modulated cellular proliferation, glycolysis and attenuated the oxidation stress and inflammation 109, 110. Indeed, experimental studies provided evidence that lycopene may act as an anti-inflammatory agent against certain types of disease, including those of the liver, lung, colon and prostate 98, 111, 112. Patients with fatty liver have significantly reduced plasma lycopene 113 …”

Section: Dietary Tomato Rich In Lycopene Inhibits Ald By Suppressing mentioning

confidence: 99%

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Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development

Stice

Xia

Wang

2018

Chronic Diseases and Translational Medicine

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Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. The incidence of hepatocellular carcinoma (HCC) is increasing in the United States, and chronic, excessive alcohol consumption is responsible for 32%–45% of all the liver cancer cases in the United States. Avoidance of chronic or excessive alcohol intake is the best protection against alcohol-related liver injury; however, the social presence and addictive power of alcohol are strong. Induction of the cytochrome P450 2E1 (CYP2E1) enzyme by chronic and excessive alcohol intake is known to play a role in the pathogenesis of ALD. High intake of tomatoes, rich in the carotenoid lycopene, is associated with a decreased risk of chronic disease. The review will overview the prevention of ALD and HCC through dietary tomato rich in lycopene as an effective intervention strategy and the crucial role of CYP2E1 induction as a molecular target. The review also indicates a need for caution among individuals consuming both alcohol and high dose lycopene as a dietary supplement.

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Section: Dietary Tomato Rich In Lycopene Inhibits Ald By Suppressing mentioning

confidence: 99%

Section: Dietary Tomato Rich In Lycopene Inhibits Ald By Suppressing mentioning

confidence: 99%

Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development

Stice

Xia

Wang

2018

Chronic Diseases and Translational Medicine

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Genetic Engineering of Lipid Biosynthesis in Seeds

Singer

Greer

Mietkiewska

et al. 2013

Biotechnology of Crucifers

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Lycopene Metabolite, Apo-10′-Lycopenoic Acid, Inhibits Diethylnitrosamine-Initiated, High Fat Diet–Promoted Hepatic Inflammation and Tumorigenesis in Mice

et al. 2013

Cancer Prevention Research

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Obesity is associated with increased risk in hepatocellular carcinoma (HCC) development and mortality. An important disease control strategy is the prevention of obesity-related hepatic inflammation and tumorigenesis by dietary means. Here, we report that apo-10′-lycopenoic acid (APO10LA), a cleavage metabolite of lycopene at its 9′,10′-double bond by carotene-9′,10′-oxygenase, functions as an effective chemopreventative agent against hepatic tumorigenesis and inflammation. APO10LA treatment on human liver THLE-2 and HuH7 cells dose-dependently inhibited cell growth and up-regulated sirtuin 1 (SIRT1), a NAD+-dependent protein deacetylase that may suppress hepatic carcinogenesis. This observed SIRT1 induction was associated with decreased cyclin D1 protein, increased cyclin-dependent kinase inhibitor p21 protein expression, and induced apoptosis. APO10LA supplementation (10 mg/kg diet) for 24 weeks significantly reduced diethylnitrosamine-initiated, high fat diet (HFD)-promoted hepatic tumorigenesis (50% reduction in tumor multiplicity; 65% in volume) and lung tumor incidence (85% reduction) in C57Bl/6J mice. The chemopreventative effects of APO10LA were associated with increased hepatic SIRT1 protein and deacetylation of SIRT1 targets, as well as with decreased caspase-1 activation and SIRT1 protein cleavage. APO10LA supplementation in diet improved glucose intolerance and reduced hepatic inflammation (decreased inflammatory foci, TNFα, IL-6, NF-κB p65 protein expression, and STAT3 activation) in HFD-fed mice. Furthermore, APO10LA suppressed Akt activation, cyclin D1 gene and protein expression, and promoted PARP protein cleavage in transformed cells within liver tumors. Taken together, this data indicates that APO10LA can effectively inhibit HFD-promoted hepatic tumorigenesis by stimulating SIRT1 signaling while reducing hepatic inflammation.

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The Role of Tomato Lycopene in Cancer Prevention

Cited by 3 publications

References 97 publications

Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development

Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development

Genetic Engineering of Lipid Biosynthesis in Seeds

Lycopene Metabolite, Apo-10′-Lycopenoic Acid, Inhibits Diethylnitrosamine-Initiated, High Fat Diet–Promoted Hepatic Inflammation and Tumorigenesis in Mice

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