Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development

Stice, Camilla P.; Xia, Hui; Wang, Xiangdong

doi:10.1016/j.cdtm.2018.11.001

Cited by 24 publications

(21 citation statements)

References 129 publications

(337 reference statements)

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“…Thus, in European countries, the total intake of carotenoids varies from 9.5 to 16 mg/day (3 to 6 mg/day for β-carotene), vegetables and fruits being the main dietary sources [84]. In the United States, the average intake of lycopene varies from 6.6 to 10.5 mg/day for men and 5.7–10.4 mg/day for women, of which more than 85% of the intake comes from tomatoes and tomato products (salsa, pasta, soup, juice, and ketchup) [85]. The intake of carotenoids in diets in various countries is shown in Table 2 [40,84,86].…”

Section: Carotenoidsmentioning

confidence: 99%

Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review

2019

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The consumption of carotenoids has beneficial effects on health, reducing the risk of certain forms of cancer, cardiovascular diseases, and macular degeneration, among others. The mechanism of action of carotenoids has not been clearly identified; however, it has been associated with the antioxidant capacity of carotenoids, which acts against reactive oxygen species and inactivating free radicals, although it has also been shown that carotenoids modulate gene expression. Dietary carotenoids are absorbed and accumulated in the liver and other organs, where they exert their beneficial effects. In recent years, it has been described that the intake of carotenoids can significantly reduce the risk of suffering from liver diseases, such as non-alcoholic fatty liver disease (NAFLD). This disease is characterized by an imbalance in lipid metabolism producing the accumulation of fat in the hepatocyte, leading to lipoperoxidation, followed by oxidative stress and inflammation. In the first phases, the main treatment of NAFLD is to change the lifestyle, including dietary habits. In this sense, carotenoids have been shown to have a hepatoprotective effect due to their ability to reduce oxidative stress and regulate the lipid metabolism of hepatocytes by modulating certain genes. The objective of this review was to provide a description of the effects of dietary carotenoids from fruits and vegetables on liver health.

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Section: Carotenoidsmentioning

confidence: 99%

Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review

2019

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“…Genistein protects hepatocytes against toxicity due to creating a resistance to oxidative stress (75). Lycopene, an antioxidant found in red fruits such as tomatoes, inhibits hepatocyte apoptosis by reducing ROS levels and inhibiting mitochondrial dysfunction, and may have the ability to prevent FLD (76). It has been suggested that dietary intake of copper chloride and/or copper sulphate stabilizes SOD activity in an animal model, indicating a potential therapeutic benefit for FLD (77).…”

Section: Diet and Hepatocyte Protectionmentioning

confidence: 99%

Diet induces hepatocyte protection in fatty liver disease via modulation of PTEN signaling (Review)

et al. 2020

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Fatty liver disease (FLD) is characterized by accumulation of excess fat in the liver. The underlying molecular mechanism associated with the progression of the disease has been in elusive. Hepatocellular demise due to increased oxidative stress resulting in an inflammatory response may be a key feature in FLD. Recent advances in molecular biology have led to an improved understanding of the molecular pathogenesis, suggesting a critical association between the PI3K/AKT/PTEN signaling pathway and FLD. In particular, PTEN has been associated with regulating the pathogenesis of hepatocyte degeneration. Given the function of mitochondria in reactive oxygen species (ROS) generation and the initiation of oxidative stress, the mitochondrial antioxidant network is of interest. It is vital to balance the activity of intracellular key molecules to maintain a healthy liver. Consequently, onset of FLD may be delayed using dietary protective agents that alter PTEN signaling and reduce ROS levels. The advancement of research on dietary regulation with a focus on modulatory roles in ROS generation and PTEN associated signaling is summarized in the current study, supporting further preventive and therapeutic exploration.

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“…Liver injury is a common clinical disease that has a wide range of detrimental effects on people's health, including liver cirrhosis, liver necrosis, fatty liver, liver cancer, and liver fibrosis (Chen, Chen, Lu, Wang, & Wang, 2015; Jiang et al., 2019; Liu, Xie, Li, Wu, & An, 2018). Many factors can lead to abnormal liver function, such as drugs, alcohol, and a range of chemical reagents (Fontana et al, 2010; Mitazaki et al., 2018; Shen et al., 2019; Stice, Xia, & Wang, 2018). Studies have shown that more than 350 drugs cause drug‐induced liver injury related to different clinical and pathological manifestations, mainly cholestasis, acute hepatitis, and acute liver failure (Björnsson & Hoofnagle, 2015; Massart et al., 2013; Ramachandran & Kakar, 2009; Watkins & Seeff, 2006).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective activity assessment of amino acids derivatives of picroside I and II

et al. 2020

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Picrorhiza kurroa has a long medicinal history as a traditional medicinal plant in China and India that is widely used in clinical treatments. It is a common treatment for liver diseases, fever, diarrhoea, indigestion, and some other diseases. Modern pharmacological studies proved that P. kurroa rhizomes have high levels of picroside I and II, which were identified as main constituents with anti‐inflammatory and hepatoprotective activities. In our study, we used picroside I and II as the lead compounds to generate derivatives by reactions with Boc‐valine or Boc‐proline, which underwent dehydration and condensation with the hydroxyl groups in the lead compounds in the presence of coupling reagent N,N′‐dicyclohexylcarbodiimide. We synthesized 11 derivatives and examined their hepatoprotective effects in vitro by assessing the proliferation rates of H2O2‐exposed HepG2 cells using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay. We found that some derivatives promoted higher proliferation rates in HepG2 cells than the natural compounds before derivatization, suggesting that those derivatives possessed an improved hepatoprotective capacity. The novel derivatization strategy for picrosides had the additional benefit that the esterification of their hydroxyl groups created derivatives not only with increased stability but also with improved pharmacokinetic properties and potentially prolonged half‐life.

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Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development

Cited by 24 publications

References 129 publications

Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review

Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review

Diet induces hepatocyte protection in fatty liver disease via modulation of PTEN signaling (Review)

Hepatoprotective activity assessment of amino acids derivatives of picroside I and II

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