The Role of the Growth Hormone/Insulin-Like Growth Factor System in Visceral Adiposity

Lewitt, Moira

doi:10.1177/1178626417703995

Cited by 43 publications

(42 citation statements)

References 182 publications

(219 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1C,D). In mammals, a decreased level of IGF-1 is commonly accompanied with obesity (Lewitt, 2017). In this study, Nile tilapia fed on the HFD for 4 weeks had decreased IGF-1 mRNA expression, increased weight gain and visceral fat deposition (Table S3), which induced obesity, consistent with previous findings in mammals.…”

Section: Results and Discussion Expression Analysis Of Igf-1 And Socssupporting

confidence: 91%

IGF-1 induces SOCS-2 but not SOCS-1 and SOCS-3 transcription in juvenile Nile tilapia (Oreochromis niloticus)

Liu

Luo

Limbu

et al. 2018

Journal of Experimental Biology

View full text Add to dashboard Cite

Insulin-like growth factor-1 (IGF-1) plays a crucial role in regulating growth in vertebrates whereas suppressors of cytokine signaling (SOCS) act as feedback inhibitors of the GH/IGF-1 axis. Although SOCS-2 binds the IGF-1 receptor and inhibits IGF-1-induced STAT3 activation, presently there is no clear evidence as to whether IGF-1 could induce SOCS gene expression. The current study aimed to determine whether IGF-1 could induce the transcription of SOCS in juvenile Nile tilapia (). We show that there is a common positive relationship between the mRNA expression of and under different nutritional statuses and stimulants, but not the mRNA expression of and Furthermore, rhIGF-1 treatment and transcriptional activity assay confirmed the hypothesis that IGF-1 could induce expression, whereas it had no effect or even decreased the expression of and Overall, we obtained evidence that the transcription of SOCS-2, but not SOCS-1 or SOCS-3, could be induced by IGF signaling, suggesting that SOCS-2 serves as a feedback suppressor of the IGF-1 axis in juvenile Nile tilapia.

show abstract

Section: Results and Discussion Expression Analysis Of Igf-1 And Socssupporting

confidence: 91%

IGF-1 induces SOCS-2 but not SOCS-1 and SOCS-3 transcription in juvenile Nile tilapia (Oreochromis niloticus)

Liu

Luo

Limbu

et al. 2018

Journal of Experimental Biology

View full text Add to dashboard Cite

show abstract

“…Among them, for example, the focus could be directed toward the complexity of the GH/IGF-1 system, consisting of GH, IGF-1, different binding proteins, and co-regulatory proteins; in such a system, several assays for the measurement of the unbound active fraction of IGF-1 have been proposed and applied, complicating the jigsaw [ 89 ]. Another missing piece of information is related to the role played by the IGFBPs with respect to the adipose tissue, through their IGF-dependent and/or IGF-independent actions ([ 128 ] and references therein). As for adiponectin, it is not known if and how the several circulating adiponectin oligomeric isoforms, from low to very high MW, could contribute differently to the modulation of the GH/IGF-1 system.…”

Section: Discussionmentioning

confidence: 99%

A Functional Interplay between IGF-1 and Adiponectin

Orrú

Nigro

Mandola

et al. 2017

IJMS

View full text Add to dashboard Cite

A functional relationship is suggested between two well-known protein hormones, insulin-like growth factor 1 (IGF-1) and adiponectin. In the last two decades in fact, different experimental evidence has indicated a non-random link between them. Here, we describe briefly the IGF-1 and adiponectin systems, and we then focus on their putative interplay in relation to several pathological conditions, including obesity, diabetes, insulin resistance, cardiovascular disease, and cancer. Although the existing studies are hardly comparable, they definitely indicate a functional connection between these two protein hormones. In conclusion, the current knowledge strongly encourages further research into the common, as well as novel, mechanisms through which IGF-1 and adiponectin exert their concerted action.

show abstract

“…Although obese individuals have lower GH production, their circulating IGF-1 concentrations were high, which could be explained by increased pre-adipocyte expression of IGF-1 and its receptor due to the effects of insulin and cortisol; thus, IGF-1 activates the proliferation of pre-adipocytes and their differentiation into adipocytes. 41 IGF-1 production in response to an increased number of adipocytes may play a role in the decreased output of GH observed in patients who suffer from obesity. 20,42,43 However, this decrease in the secretion of this hormone is not associated with an alteration in the speed of growth, since obese children usually have a normal or even increased height for their age; for example, in this study, the obese group was 7cm taller than children of similar age with adequate weight.…”

Section: Discussionmentioning

confidence: 99%

Marcadores de riesgo cardiovascular en niños menores de 10 años y su relación con niveles séricos de IGF-1, IGFBP-1, IGFBP-2 e IGFBP-3

et al. 2020

View full text Add to dashboard Cite

Introduction: Any type of nutritional imbalance experienced during childhood will affect the health of an individual, both in their childhood and their adulthood. Several studies have proved that there is an association between cardiovascular disease (CVD) risk and endocrine and lipid markers at early stages of life. Objective: To establish the relationship between nutritional status (IGF-1 and serum levels of its binding proteins IGFBP-1, IGFBP-2 and IGFBP-3), and CVD risk markers in students aged 7 to 9 years. Materials and methods: Cross-sectional observational study conducted in 84 children attending two schools from Bogotá D.C. and Soacha, Colombia, to identify the relationship between possible variations in CVD risk markers and nutritional status. Sexual development stage, lipid profile, anthropometric data, blood sugar levels and IGF-1 and IGFBP serum levels of all participants were measured. Statistical analysis was conducted using the Pearson's correlation coefficient, the analysis of variance (ANOVA), and the Kruskall-Wallis, Games-Howell and Dunnett's tests. The confidence interval and statistical significance were 95% and p<0.05, respectively. Results: IGFBP-1 and IGFBP-2 levels proportionally decreased as weight increased. An inverse correlation between both proteins and triglyceride levels was found, as well as a direct correlation with HDL cholesterol levels. Conclusions: Alterations in CVD risk markers can be identified during childhood. If said alterations are timely detected, it is possible to adopt preventive and therapeutic actions such as the promotion of public policies aimed at preventing childhood overweight and obesity, which in turn will reduce the risk of developing cardiovascular disease in adulthood.Introducción. Los desequilibrios nutricionales en la infancia afectan la salud tanto en la niñez como en la adultez. Estudios previos demuestran la asociación de marcadores endocrinos y lipídicos con riesgo cardiovascular (RCV) desde edades tempranas. Objetivo. Establecer la relación entre estado nutricional (niveles séricos de IGF-1 y sus proteínas enlazantes IGFBP-1, IGFBP-2 e IGFBP-3) y marcadores de RCV en estudiantes de 7 a 9 años. Materiales y métodos. Estudio observacional comparativo transversal realizado en 84 niños de 2 colegios de Bogotá D.C. y Soacha, Colombia, para identificar la relación entre posibles variaciones de marcadores de RCV y estado nutricional. Se midieron los niveles de glucemia y niveles séricos de IGF-1 e IGFBP, el nivel de desarrollo sexual, el perfil lipídico y los valores antropométricos. Para el análisis estadístico se utilizaron el coeficiente de correlación de Pearson, un análisis de varianza (ANOVA) y las pruebas de Kruskal Wallis, Games-Howell y Dunnett. El intervalo de confianza fue del 95% y la significancia estadística, de p<0.05. Resultados. La reducción en los niveles de IGFB-1 e IGFBP-2 fue directamente proporcional al aumento de peso. Por otra parte, se observó una correlación inversa entre ambas proteínas y concentraciones de triglicéridos, y un...

show abstract

The Role of the Growth Hormone/Insulin-Like Growth Factor System in Visceral Adiposity

Cited by 43 publications

References 182 publications

IGF-1 induces SOCS-2 but not SOCS-1 and SOCS-3 transcription in juvenile Nile tilapia (Oreochromis niloticus)

IGF-1 induces SOCS-2 but not SOCS-1 and SOCS-3 transcription in juvenile Nile tilapia (Oreochromis niloticus)

A Functional Interplay between IGF-1 and Adiponectin

Marcadores de riesgo cardiovascular en niños menores de 10 años y su relación con niveles séricos de IGF-1, IGFBP-1, IGFBP-2 e IGFBP-3

Contact Info

Product

Resources

About