Introduction: Any type of nutritional imbalance experienced during childhood will affect the health of an individual, both in their childhood and their adulthood. Several studies have proved that there is an association between cardiovascular disease (CVD) risk and endocrine and lipid markers at early stages of life. Objective: To establish the relationship between nutritional status (IGF-1 and serum levels of its binding proteins IGFBP-1, IGFBP-2 and IGFBP-3), and CVD risk markers in students aged 7 to 9 years. Materials and methods: Cross-sectional observational study conducted in 84 children attending two schools from Bogotá D.C. and Soacha, Colombia, to identify the relationship between possible variations in CVD risk markers and nutritional status. Sexual development stage, lipid profile, anthropometric data, blood sugar levels and IGF-1 and IGFBP serum levels of all participants were measured. Statistical analysis was conducted using the Pearson's correlation coefficient, the analysis of variance (ANOVA), and the Kruskall-Wallis, Games-Howell and Dunnett's tests. The confidence interval and statistical significance were 95% and p<0.05, respectively. Results: IGFBP-1 and IGFBP-2 levels proportionally decreased as weight increased. An inverse correlation between both proteins and triglyceride levels was found, as well as a direct correlation with HDL cholesterol levels. Conclusions: Alterations in CVD risk markers can be identified during childhood. If said alterations are timely detected, it is possible to adopt preventive and therapeutic actions such as the promotion of public policies aimed at preventing childhood overweight and obesity, which in turn will reduce the risk of developing cardiovascular disease in adulthood.Introducción. Los desequilibrios nutricionales en la infancia afectan la salud tanto en la niñez como en la adultez. Estudios previos demuestran la asociación de marcadores endocrinos y lipídicos con riesgo cardiovascular (RCV) desde edades tempranas. Objetivo. Establecer la relación entre estado nutricional (niveles séricos de IGF-1 y sus proteínas enlazantes IGFBP-1, IGFBP-2 e IGFBP-3) y marcadores de RCV en estudiantes de 7 a 9 años. Materiales y métodos. Estudio observacional comparativo transversal realizado en 84 niños de 2 colegios de Bogotá D.C. y Soacha, Colombia, para identificar la relación entre posibles variaciones de marcadores de RCV y estado nutricional. Se midieron los niveles de glucemia y niveles séricos de IGF-1 e IGFBP, el nivel de desarrollo sexual, el perfil lipídico y los valores antropométricos. Para el análisis estadístico se utilizaron el coeficiente de correlación de Pearson, un análisis de varianza (ANOVA) y las pruebas de Kruskal Wallis, Games-Howell y Dunnett. El intervalo de confianza fue del 95% y la significancia estadística, de p<0.05. Resultados. La reducción en los niveles de IGFB-1 e IGFBP-2 fue directamente proporcional al aumento de peso. Por otra parte, se observó una correlación inversa entre ambas proteínas y concentraciones de triglicéridos, y un...
Introduction: Nutritional vulnerability is more evident during childhood, since malnutrition has an impact on academic performance and is linked to different diseases during this period. Likewise, an increase in the incidence and prevalence of obesity in children has been observed, therefore, researches that assess nutritional conditions of children attending schools may have high-impact results in terms of public health.Objective: To relate children’s nutritional condition by using anthropometry, with serum concentrations of insulin-like growth factor 1 (IGF-1) and its binding protein 2 (IGFBP-2).Materials and methods: A cross-sectional observational and comparative study was performed in children aged 7 to 9 attending two schools, one from the public sector and the other from the private sector. An anthropometric assessment was performed in 157 children, while IGF-1 and IGFBP (enzyme immunoassay) serum concentrations were measured in 81 children. Pearson’s coefficient, analysis of variance (ANOVA), Dunnet’s test and Games Howell’s test, with a 95% confidence interval and a p<0.05 statistical significance, were considered for performing the statistical analysis.Results: Overweight and obesity were found in 46 subjects; the prevalence of obesity was higher in boys, while overweight prevalence was higher in girls. A direct relation between IGF-1 and height (p<0,05) was observed, while an inverse relation between IGFBP-2 and BMI (p<0,001) was found.Conclusions: IGF-1 serum concentrations were higher in students attending the public school.
Objetivo: determinar cambios y correlaciones de niveles salivales de melatonina, ingesta de alimentos, concentraciones séricas de leptina, insulina, glucosa e índice de resistencia a insulina después de siete noches de trabajo nocturno. Se han registrado mayores riesgos de padecer obesidad y diabetes en los trabajadores por turnos, así como, variaciones en las concentraciones de melatonina. Materiales y métodos: estudio exploratorio de tipo descriptivo comparativo; participaron diez hombres, vigilantes de seguridad quienes laboraban turnos diurnos de 6 a.m. a 3 p.m. y nocturnos de 10 p.m. a 6 a.m. Se determinaron variables antropométricas. Durante el último turno diurno y al finalizar el último turno nocturno se estimó la ingesta de alimentos y para medir los diferentes biomarcadores se tomaron muestras de sangre y saliva a las 7 a.m., y a continuación los sujetos recolectaron muestras de saliva a la 1 p.m., 9 p.m. y 2 a.m. Resultados: después de siete noches de trabajo, los niveles de melatonina a la 1 pm, glucemia y leptina fueron mayores, asimismo, el consumo de calorías totales aumentó a expensas de proteínas y carbohidratos. La correlación negativa entre melatonina e insulinorresistencia no fue estadísticamente significativa. Conclusiones: se confirmaron efectos del turno nocturno sobre los niveles de melatonina al día siguiente de culminada la rotación laboral. Durante el turno nocturno, los trabajadores consumieron más calorías y presentaron mayor glucemia, situaciones que incrementan la susceptibilidad a desarrollar obesidad y diabetes. Asimismo, la leptina sérica aumentó, lo que puede acrecentar el riesgo de padecer síndrome metabólico.
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