The Role of Soluble Adhesion Molecules and Cytokines in Sudden Sensorineural Hearing Loss

Haubner, Frank; Martin, Ludwig; Steffens, Thomas; Strutz, Jürgen; Kleinjung, Tobias

doi:10.1177/0194599810394324

Cited by 22 publications

(25 citation statements)

References 29 publications

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“…Masuda et al [9] reported that the increase in neutrophil count was correlated with a poor prognosis for SSNHL patients. Studies performed with inflammatory cytokines, like TNF alpha, interleukin 6, and interleukin 10, demonstrated that these cytokines were not correlated with SSNHL [16,17] . Neutrophil-to-lymphocyte ratio (NLR) is calculated by dividing the neutrophil count obtained from the CBC analysis by the lymphocyte count.…”

Section: Discussionmentioning

confidence: 99%

New Inflammation Parameters in Sudden Sensorineural Hearing Loss: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio

İkincioğulları¹,

Köseoğlu²,

Kılıç³

et al. 2015

Int Adv Otol

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OBJECTIVE:The etiopathogenesis of sudden sensorineural hearing loss (SSNHL) is not clearly defined. Inflammation is being emphasized in its etiology. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are the parameters that show inflammation that can be obtained easily without additional cost. In this study, we aimed at delineating the relationship between SSNHL and the inflammation markers NLR and PLR. MATERIALS and METHODS:This study was performed with 102 patients diagnosed with SSNHL and 119 sex-and age-matched controls. All subjects in the study and the control group had their complete blood count (CBC) results, which were evaluated retrospectively to calculate NLR and PLR values. All patients underwent an audiological examination on the 1 st , 3rd, 10 th , and 30 th days of the hearing loss. All patients received 1 mg/kg IV prednisolone treatment in tapered amounts to be completed in 15 days. Based on the improvements seen in the audiograms, the patients were divided into two groups: responders and non-responders to treatment. RESULTS:PLR and NLR values of the patient group were significantly higher than in the control group (p<0.001, p<0.001). Furthermore, patients who responded to treatment had significantly higher NLR values than those who did not respond (p=0.010). CONCLUSION:In this study, NLR and PLR values were found to be significantly high in SSNHL patients. PLR value was investigated for the first time in the literature in SSNHL patients. NLR and PLR values are parameters that aid in the diagnosis of SSNHL. Moreover, SSNHL patients who had higher NLR values responded to the treatment better.

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Section: Discussionmentioning

confidence: 99%

New Inflammation Parameters in Sudden Sensorineural Hearing Loss: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio

İkincioğulları¹,

Köseoğlu²,

Kılıç³

et al. 2015

Int Adv Otol

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show abstract

“…7,14,21,22 However, the molecular mechanism of these cytokines in the ISSNHL is poorly understood, and there are controversial results among published studies. 7,14,21,22 However, the molecular mechanism of these cytokines in the ISSNHL is poorly understood, and there are controversial results among published studies.…”

Section: Discussionmentioning

confidence: 99%

Blood levels ofTNF‐α,IL‐10, andIL‐12in idiopathic sudden sensorineural hearing loss

Demirhan

Eşkut

Zorlu³

et al. 2013

The Laryngoscope

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“…Haubner et al (54) demonstrated that IL-6 concentration was not significantly different between 48 ISHL patients of various levels of HL and 35 control subjects, although no distinction were made between mild and severe ISHL. In the report, the IL-6 concentration not only from severe ISHL patients but also milder patients might counterbalance the increase of IL-6 in severe ISHL patients.…”

Section: Figmentioning

confidence: 99%

Correlations of Inflammatory Biomarkers With the Onset and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss

Masuda¹,

Kanzaki²,

Minami³

et al. 2012

Otology &Amp; Neurotology

131

129

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Neutrophil counts above the reference range of a facility will be a useful indicator of poor prognosis of ISHL. Synchronism of different types of NF-κB activation pathways could be required to cause severe ISHL. An NKCA decrease, an acute neutrophil count increase, and an IL-6 increase can induce NF-κB activation in the cochlea and cause severe ISHL. Further epidemiologic surveys should be conducted to evaluate whether stressful life events increase the risk of severe ISHL onset.

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The Role of Soluble Adhesion Molecules and Cytokines in Sudden Sensorineural Hearing Loss

Cited by 22 publications

References 29 publications

New Inflammation Parameters in Sudden Sensorineural Hearing Loss: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio

New Inflammation Parameters in Sudden Sensorineural Hearing Loss: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio

Blood levels ofTNF‐α,IL‐10, andIL‐12in idiopathic sudden sensorineural hearing loss

Correlations of Inflammatory Biomarkers With the Onset and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss

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