New Inflammation Parameters in Sudden Sensorineural Hearing Loss: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio

Abstract

OBJECTIVE:The etiopathogenesis of sudden sensorineural hearing loss (SSNHL) is not clearly defined. Inflammation is being emphasized in its etiology. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are the parameters that show inflammation that can be obtained easily without additional cost. In this study, we aimed at delineating the relationship between SSNHL and the inflammation markers NLR and PLR. MATERIALS and METHODS:This study was performed with 102 patients diagnosed with SSNHL and 119 sex-and age-matched controls. All subjects in the study and the control group had their complete blood count (CBC) results, which were evaluated retrospectively to calculate NLR and PLR values. All patients underwent an audiological examination on the 1 st , 3rd, 10 th , and 30 th days of the hearing loss. All patients received 1 mg/kg IV prednisolone treatment in tapered amounts to be completed in 15 days. Based on the improvements seen in the audiograms, the patients were divided into two groups: responders and non-responders to treatment. RESULTS:PLR and NLR values of the patient group were significantly higher than in the control group (p<0.001, p<0.001). Furthermore, patients who responded to treatment had significantly higher NLR values than those who did not respond (p=0.010). CONCLUSION:In this study, NLR and PLR values were found to be significantly high in SSNHL patients. PLR value was investigated for the first time in the literature in SSNHL patients. NLR and PLR values are parameters that aid in the diagnosis of SSNHL. Moreover, SSNHL patients who had higher NLR values responded to the treatment better.

Investigation of neutrophil-to-lymphocyte ratio and red cell distribution width in sudden senseurineural hearing loss

“…Higher neutrophil counts may be associated with inflammatory conditions. 8 The NLR is an inflammatory marker that has been studied in recent years for many diseases. The presence of an elevated NLR in SSHL demonstrated via the literature search.…”

“…Less than 10 dB improvement in hearing level relative to the initial hearing level. 8 Systemic otorhinolaryngological examinations performed. Whole blood analysis results evaluated retrospectively.…”

Platelet Count Increases in Chronic Otitis Media Patients With Blocked Eustachian Tube

“…Platelets interact with both leukocytes and endothelial cells, secrete chemokins and generate inflammatory lipids (12,13). The NLR and PLR serve as inflammatory biomarkers in diseases including Behcet's syndrome, Rheumatoid arthritis, sudden hearing loss, nasal polyposis, cardiovascular diseases and malignancy in all of which systemic inflammation is an important feature (14)(15)(16)(17)(18)(19)(20)(21)(22)(23). The MPV may be a new marker of inflammation in Behcet's syndrome, asthma, chronic obstructive pulmonary disease, arthritis (20,24,25).…”

“…Recent studies have found that, the neutrophil to lymphocyte ratio (NLR), the mean platelet volume (MPV) and the platelet to lymphocyte ratio (PLR) are of diagnostic and predictive utility in systemic inflammatory disorders, cancer, cardiovascular diseases which may be used as diagnostic and prognostic indicators (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). These ratios have also been investigated as biomarkers of sudden idiopathic sensoryneural hearing loss and nasal polyposis (18)(19)(20). The aim of the present study was to examine the levels of complete blood count (CBC) parameters (Neutrophil, lymphocyte, platelets, MPV, NLR, and PLR) in patients with both perforated eardrums and dysfunctional eustachian tubes to determine which of these parameters might be reliable biomarkers of chronic otitis media prior to surgery, as inflammation is significant component of middle ear pathology.…”

The etiopathogenetic aspects of idiopathic sensorineural impairment of hearing

“…Повышение тромбоцитарно-лимфоцитарного отношения наблюдается при различных нарушениях периферического кровообращения, патологии коронарных артерий, некоторых злокачественных новообразованиях. Высокое нейтрофильно-лимфоцитарное отношение характерно для системного воспалительного процесса, являясь плохим прогностическим признаком [48]. Повышение нейтрофильно-лимфоцитарного отношения имеет место при различных заболеваниях сердечно-сосудистой системы, параличе Бэлла, почечной недостаточности, ИНСТ.…”