Blood levels of<scp>TNF‐α</scp>,<scp>IL‐10</scp>, and<scp>IL‐12</scp>in idiopathic sudden sensorineural hearing loss

Demirhan, Erhan; Eşkut, Neslihan; Zorlu, Yaşar; Çukurova, İbrahim; Tuna, Gamze; Kirkali, Fatos Guldal

doi:10.1002/lary.23907

Cited by 37 publications

(59 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our result supports the study by Demirhan et al [2013] which showed that TNFα posttreatment values are elevated in the treatment nonresponders and complies with both clinical trials and case reports in the literature that favor the use of TNFα inhibitors in the treatment of ISSNHL [Staecker and Lefebvre, 2002;Satoh et al, 2002Satoh et al, , 2003Van Wijk et al, 2006;Demirhan et al, 2013]. With the exception of our study and the one recently published by Demirhan et al, the variation of TNFα expression has not been evaluated in other research protocols.…”

Section: Discussionsupporting

confidence: 73%

The Expression of TNFα, IL-6, IL-2 and IL-8 in the Serum of Patients with Idiopathic Sudden Sensorineural Hearing Loss: Possible Prognostic Factors of Response to Corticosteroid Treatment

Tsinaslanidou¹,

Tsaligopoulos

Angouridakis³

et al. 2016

Audiol Neurotol Extra

View full text Add to dashboard Cite

Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) remains one of the major unsolved otologic emergencies. A viral infection, a systemic inflammatory disorder, as well as physical, mental and metabolic stress can trigger an innate immune response in the inner ear resulting in ISSNHL. Proinflammatory cytokines play a central role in this cochlear immunological cascade. Objective: To examine the expression of proinflammatory cytokines in the serum of patients with ISSNHL in correlation with the therapeutic outcome of intravenous administration of corticosteroids. Method: Forty-three patients primarily diagnosed with ISSNHL underwent intravenous corticosteroid treatment for 8 days. The expression of tumor necrosis factor-α (TNFα), interleukin-6 (IL-6), interleukin-2 (IL-2) and interleukin-8 (IL-8) was detected with the use of enzyme-linked immunosorbent assay in serum specimens on the 1st and 8th day of treatment and it was correlated with the treatment outcome. Results: TNFα reduction and IL-6 increase strongly correlate with a good therapeutic result [χ²(2) = 13.12, p = 0.001 and χ²(2) = 16.78, p = 0.0001]. IL-8 increase reflects negatively on the outcome, however, not in a statistically significant way. No association was established between IL-2 variations and the therapeutic outcome. Conclusions: TNFα and IL-6 can be used as prognostic factors for the treatment outcome, whereas the prognostic value of IL-8 requires further statistical confirmation.

show abstract

Section: Discussionsupporting

confidence: 73%

The Expression of TNFα, IL-6, IL-2 and IL-8 in the Serum of Patients with Idiopathic Sudden Sensorineural Hearing Loss: Possible Prognostic Factors of Response to Corticosteroid Treatment

Tsinaslanidou¹,

Tsaligopoulos

Angouridakis³

et al. 2016

Audiol Neurotol Extra

View full text Add to dashboard Cite

show abstract

“…Generally, it is an increase in TNF-α signaling, either secondary to disease or via pharmacological manipulation, that will cause loss of hair cells or auditory function, while blocking TNF-α affords protection in both human and animal models. Patients with idiopathic sensorineural hearing loss who did not respond to drug treatment maintained higher blood levels of TNF-α than positive responders (Demirhan et al 2013). Autoimmune sensorineural hearing loss was also attenuated by TNF-α blockers in a prospective pilot study (van Wijk et al 2006).…”

Section: Discussionmentioning

confidence: 98%

Tumor Necrosis Factor-alpha-mutant Mice Exhibit High Frequency Hearing Loss

Oishi

Zheng

Hill

et al. 2013

JARO

View full text Add to dashboard Cite

Exogenous tumor necrosis factor-alpha (TNF-α) plays a role in auditory hair cell death by altering the expression of apoptosis-related genes in response to noxious stimuli. Little is known, however, about the function of TNF-α in normal hair cell physiology. We, therefore, investigated the cochlear morphology and auditory function of TNF-α-deficient mice. Auditory evoked brainstem response showed significantly higher thresholds, especially at higher frequencies, in 1-month-old TNF-α −/− mice as compared to TNF-α +/− and wild type (WT); hearing loss did not progress further from 1 to 4 months of age. There was no difference in the gross morphology of the organ of Corti, lateral wall, and spiral ganglion cells in TNF-α −/− mice compared to WT mice at 4 months of age, nor were there differences in the anatomy of the auditory ossicles. Outer hair cells were completely intact in surface preparations of the organ of Corti of TNF-α −/− mice, and synaptic ribbon counts of TNF-α −/− and WT mice at 4 months of age were similar. Reduced amplitudes of distortion product otoacoustic emissions, however, indicated dysfunction of outer hair cells in TNF-α −/− mice. Scanning electron microscopy revealed that stereocilia were sporadically absent in the basal turn and distorted in the middle turn. In summary, our results demonstrate that TNF-α-mutant mice exhibit early hearing loss, especially at higher frequencies, and that loss or malformation of the stereocilia of outer hair cells appears to be a contributing factor.

show abstract

“…Masuda et al [9] reported that the increase in neutrophil count was correlated with a poor prognosis for SSNHL patients. Studies performed with inflammatory cytokines, like TNF alpha, interleukin 6, and interleukin 10, demonstrated that these cytokines were not correlated with SSNHL [16,17] . Neutrophil-to-lymphocyte ratio (NLR) is calculated by dividing the neutrophil count obtained from the CBC analysis by the lymphocyte count.…”

Section: Discussionmentioning

confidence: 99%

New Inflammation Parameters in Sudden Sensorineural Hearing Loss: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio

İkincioğulları¹,

Köseoğlu²,

Kılıç³

et al. 2015

Int Adv Otol

View full text Add to dashboard Cite

OBJECTIVE:The etiopathogenesis of sudden sensorineural hearing loss (SSNHL) is not clearly defined. Inflammation is being emphasized in its etiology. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are the parameters that show inflammation that can be obtained easily without additional cost. In this study, we aimed at delineating the relationship between SSNHL and the inflammation markers NLR and PLR. MATERIALS and METHODS:This study was performed with 102 patients diagnosed with SSNHL and 119 sex-and age-matched controls. All subjects in the study and the control group had their complete blood count (CBC) results, which were evaluated retrospectively to calculate NLR and PLR values. All patients underwent an audiological examination on the 1 st , 3rd, 10 th , and 30 th days of the hearing loss. All patients received 1 mg/kg IV prednisolone treatment in tapered amounts to be completed in 15 days. Based on the improvements seen in the audiograms, the patients were divided into two groups: responders and non-responders to treatment. RESULTS:PLR and NLR values of the patient group were significantly higher than in the control group (p<0.001, p<0.001). Furthermore, patients who responded to treatment had significantly higher NLR values than those who did not respond (p=0.010). CONCLUSION:In this study, NLR and PLR values were found to be significantly high in SSNHL patients. PLR value was investigated for the first time in the literature in SSNHL patients. NLR and PLR values are parameters that aid in the diagnosis of SSNHL. Moreover, SSNHL patients who had higher NLR values responded to the treatment better.

show abstract

Blood levels ofTNF‐α,IL‐10, andIL‐12in idiopathic sudden sensorineural hearing loss

Abstract: IL-10 and IL-12 may not play a critical role in idiopathic sudden sensorineural hearing loss. But our data supports the role of TNF-α in the pathophysiology of idiopathic sudden sensorineural hearing loss, and TNF-α receptor blockers may have benefits in these patients.

Cited by 37 publications

References 33 publications

The Expression of TNFα, IL-6, IL-2 and IL-8 in the Serum of Patients with Idiopathic Sudden Sensorineural Hearing Loss: Possible Prognostic Factors of Response to Corticosteroid Treatment

The Expression of TNFα, IL-6, IL-2 and IL-8 in the Serum of Patients with Idiopathic Sudden Sensorineural Hearing Loss: Possible Prognostic Factors of Response to Corticosteroid Treatment

Tumor Necrosis Factor-alpha-mutant Mice Exhibit High Frequency Hearing Loss

New Inflammation Parameters in Sudden Sensorineural Hearing Loss: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio

Contact Info

Product

Resources

About