The role of sleep in forgetting in temporal lobe epilepsy: A pilot study

Deak, Maryann C.; Stickgold, Robert; Pietras, Alison C.; Nelson, Aaron P.; Bubrick, Ellen J.

doi:10.1016/j.yebeh.2011.04.061

Cited by 40 publications

(28 citation statements)

References 20 publications

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“…These results are in line with a pilot study in temporal lobe epilepsy (Deak et al., 2011) in which patients forgot significantly more than controls over a day of wakefulness but not over a night of sleep. This pilot study did not fully control for potential group differences in learning and circadian fluctuations in performance, and the task was not sensitive to the benefit of sleep for memory consolidation in healthy control subjects.…”

Section: Discussionsupporting

confidence: 92%

Sleep-dependent memory consolidation and accelerated forgetting

Atherton

Nobre

Zeman

et al. 2014

Cortex

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Accelerated long-term forgetting (ALF) is a form of memory impairment in which learning and initial retention of information appear normal but subsequent forgetting is excessively rapid. ALF is most commonly associated with epilepsy and, in particular, a form of late-onset epilepsy called transient epileptic amnesia (TEA). ALF provides a novel opportunity to investigate post-encoding memory processes, such as consolidation. Sleep is implicated in the consolidation of memory in healthy people and a deficit in sleep-dependent memory consolidation has been proposed as an explanation for ALF. If this proposal were correct, then sleep would not benefit memory retention in people with ALF as much as in healthy people, and ALF might only be apparent when the retention interval contains sleep. To test this theory, we compared performance on a sleep-sensitive memory task over a night of sleep and a day of wakefulness. We found, contrary to the hypothesis, that sleep benefits memory retention in TEA patients with ALF and that this benefit is no smaller in magnitude than that seen in healthy controls. Indeed, the patients performed significantly more poorly than the controls only in the wake condition and not the sleep condition. Patients were matched to controls on learning rate, initial retention, and the effect of time of day on cognitive performance. These results indicate that ALF is not caused by a disruption of sleep-dependent memory consolidation. Instead, ALF may be due to an encoding abnormality that goes undetected on behavioural assessments of learning, or by a deficit in memory consolidation processes that are not sleep-dependent.

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Section: Discussionsupporting

confidence: 92%

Sleep-dependent memory consolidation and accelerated forgetting

Atherton

Nobre

Zeman

et al. 2014

Cortex

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“…The authors reported the occurrence of ALF over a period of 12 hours of wakefulness, but not over a comparable period of sleep, suggesting that ALF is not caused by disruption of sleepdependent memory consolidation. These results are in line with other findings in temporal lobe epilepsy [38,49,50]. However, some patients exhibit ALF over hours [26,27], while others over days, weeks or months [9,16,22,28].…”

Section: Accelerated Rate Of Forgettingsupporting

confidence: 92%

Transient epileptic amnesia: Update on a slowly emerging epileptic syndrome

2015

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“…This is in line with an earlier pilot study of forgetting in epilepsy [111] and further supported by animal studies, as rat models of TLE show normal replay of behavior-driven sequences of single cell hippocampal activity during sleep [112]. In contrast, these three studies suggest that activity during periods of wakefulness following learning, possibly within the first few hours [113], may be more closely linked to ALF, as would be predicted by interference-based models of amnesia (e.g., [114,115]).…”

Section: Possible Mechanisms For Alfsupporting

confidence: 92%

Third International Congress on Epilepsy, Brain, and Mind: Part 2

Rektor¹,

Schachter²,

Arya³

et al. 2015

Epilepsy & Behavior

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*Corresponding author at: 165 Cambridge Street, Suite 702, Boston, MA 02114, USA. Tel.: +1 617 643 3835. sschacht@bidmc.harvard.edu (S.C. Schachter). Conflict of interestNone of the authors have any conflicts of interest to disclose. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptEpilepsyis both a disease of the brain and the mind. Here, we present the first of two papers with extended summaries of selected presentations of the Third International Congress on Epilepsy, Brain and Mind (April 3-5, 2014; Brno, Czech Republic). Epilepsy in history and the arts and its relationships with religion were discussed, as were overviews of epilepsy and relevant aspects of social cognition, handedness, accelerated forgetting and autobiographical amnesia, and large-scale brain networks.

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The role of sleep in forgetting in temporal lobe epilepsy: A pilot study

Cited by 40 publications

References 20 publications

Sleep-dependent memory consolidation and accelerated forgetting

Sleep-dependent memory consolidation and accelerated forgetting

Transient epileptic amnesia: Update on a slowly emerging epileptic syndrome

Third International Congress on Epilepsy, Brain, and Mind: Part 2

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