When individuals were grouped by biomarker status, those who were positive on Aβ or ND had the highest report of SCC compared to biomarker-negative individuals. Findings were consistent when SCC was used to predict Aβ positivity. Taken together, results suggest that both Aβ and ND are associated with SCC, independent of objective memory performance. Enrichment of individuals with SCC may increase likelihood of Aβ and ND markers in potential participants for secondary prevention trials.

The purpose of this study is to examine how sleep impacts memory function in temporal lobe epilepsy (TLE). TLE patients (n=7) and control subjects (n=9) underwent training and overnight testing on (1) a motor sequence task (MST) known to undergo sleep-dependent enhancement in healthy subjects, and (2) the selective reminding test (SRT), a verbal memory task on which TLE patients have shown impaired performance 24 hours after training. Sleep data was collected by polysomnography. Results indicate that TLE patients display greater forgetting on the SRT compared to controls over 12 hours of daytime wake, but not over a similar period including a night of sleep. Slow wave sleep is correlated with overnight performance change on the SRT. TLE patients show no deficit in sleep-dependent MST improvement. The findings provide potential insight into the pattern and pathophysiology of forgetting in TLE.

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