Past experience provides a rich source of predictive information about the world that could be used to guide and optimize ongoing perception. However, the neural mechanisms that integrate information coded in long-term memory (LTM) with ongoing perceptual processing remain unknown. Here, we explore how the contents of LTM optimize perception by modulating anticipatory brain states. By using a paradigm that integrates LTM and attentional orienting, we first demonstrate that the contents of LTM sharpen perceptual sensitivity for targets presented at memory-predicted spatial locations. Next, we examine oscillations in EEG to show that memory-guided attention is associated with spatially specific desynchronization of alpha-band activity over visual cortex. Additionally, we use functional MRI to confirm that target-predictive spatial information stored in LTM triggers spatiotopic modulation of preparatory activity in extrastriate visual cortex. Finally, functional MRI results also implicate an integrated cortical network, including the hippocampus and a dorsal frontoparietal circuit, as a likely candidate for organizing preparatory states in visual cortex according to the contents of LTM. O ur expectations shape how we see the world. From the earliest pioneers in perception (e.g., ref. 1), it has long been appreciated that past experience guides perceptual processing and decision-making. Indeed, the statistical regularities of the environment, extracted over past experience and coded in longterm memory (LTM), provide a rich source of predictive information that could be exploited to optimize perception for goal-directed behavior (2-4).Studies of selective attention provide an important framework for understanding the dynamic changes in neural processing that optimize perceptual analysis for goal-specific input. In particular, influential theories suggest that modulations in baseline neural activity in sensory cortex bias perceptual processing in favor of behaviorally relevant information (5-7). For example, a cue stimulus that provides information about the likely location of a target triggers a shift in baseline activity for neurons that represent the cued position (8-11), thereby increasing the neural sensitivity for subsequent stimulation at the attended region of space (10, 11). However, in everyday life, we rarely enjoy the benefit of explicit cues to guide our attention. More typically, we must rely on our own past experiences, stored in LTM, to build the predictions that shape perception for goal-directed behavior.Despite the obvious biological relevance of experience-based perceptual biasing, few studies have directly examined how memory influences attentional control. Studies of contextual cueing (2) demonstrate a close relationship between past experience and visual search efficiency: search times decrease with repeated exposure to the same stimulus configurations, even when repetitions are not explicitly processed (12). Contextual cueing effects are particularly compelling for detail-rich naturalistic scen...

We present the design and initial investigation of a fibre optical system which may be used both for intra-cavity and for ring-down measurements of absorption losses. The system consists of a fibre loop containing a length of erbium-doped fibre pumped at 980 nm, with gain adjustment below or above threshold for the two types of operation. The fibre loop is constructed from standard fibre optical components and includes a micro-optical gas cell. The intended application is for measurement of levels of trace gases which possess near-IR absorption lines within the gain bandwidth of the erbium fibre amplifier. We discuss the key issues involved in operation of the system and the level of sensitivity required. Our initial experimental investigations have demonstrated that ring-down times of several microseconds can be obtained, which can be altered through adjustment of the attenuation or gain factor of the loop. Gain control is one of the most important issues and we explain how this may be achieved.

Accelerated long-term forgetting (ALF) is a form of memory impairment in which learning and initial retention of information appear normal but subsequent forgetting is excessively rapid. ALF is most commonly associated with epilepsy and, in particular, a form of late-onset epilepsy called transient epileptic amnesia (TEA). ALF provides a novel opportunity to investigate post-encoding memory processes, such as consolidation. Sleep is implicated in the consolidation of memory in healthy people and a deficit in sleep-dependent memory consolidation has been proposed as an explanation for ALF. If this proposal were correct, then sleep would not benefit memory retention in people with ALF as much as in healthy people, and ALF might only be apparent when the retention interval contains sleep. To test this theory, we compared performance on a sleep-sensitive memory task over a night of sleep and a day of wakefulness. We found, contrary to the hypothesis, that sleep benefits memory retention in TEA patients with ALF and that this benefit is no smaller in magnitude than that seen in healthy controls. Indeed, the patients performed significantly more poorly than the controls only in the wake condition and not the sleep condition. Patients were matched to controls on learning rate, initial retention, and the effect of time of day on cognitive performance. These results indicate that ALF is not caused by a disruption of sleep-dependent memory consolidation. Instead, ALF may be due to an encoding abnormality that goes undetected on behavioural assessments of learning, or by a deficit in memory consolidation processes that are not sleep-dependent.

We discuss the relative merits of passive and active fiber cavities for ring-down. Ring-down times of approximately 2 micros were recently demonstrated in passive cavities, but operation is restricted to weak evanescent wave interaction. We report on active cavities with amplifiers used for loss compensation, permitting the use of open-path micro-optic cells. Ring-down times of tens of microseconds can readily be achieved and extended to several hundred microseconds in gain-clamped cavities, but relaxation oscillations and system drift impose limits on accuracy and repeatability. A cavity enhancement of 2 orders of magnitude is realistically possible, and sensitivity may be further enhanced if ring-down is combined with established spectroscopic methods.

No abstract