The Role of Serum Trace Elements and Oxidative Stress in Egyptian Breast Cancer Patients

Abstract

Background: Oxidative stress is considered to be involved in the pathophysiology of all cancers. Studies indicated that the levels of oxidative stress markers increased in breast cancer. Trace metals are essential to normal human homeostasis. When present in an abnormal expression, they contribute in many pathological processes. Some trace metals are claimed to be carcinogenic and capable of inducing a toxic effect through the formation of free radicles and acting as cofactors in the oxidative damage of biological macromolecules and DNA. Objective: Our aim was to investigate the serum levels of some trace elements (Copper, Zinc and Cadmium), the total oxidative and antioxidative capacity (TOC and TAC) in patients with breast cancer in comparison to patients with benign breast tumours. Patients and Methods: The present study included 65 females. The participates were divided into 2 main groups: control group which consisted of 20 apparently healthy female; the patient groups which divided into 3 groups: group B included 15 patients with benign breast tumours, group N consisted of 15 newly diagnosed breast cancer patients and group M included 15 patients with metastatic breast cancer. Results: The mean serum levels of Copper, Zinc, and Cadmium were significantly higher in the three patients groups (B, N and M) than the control group. Similarly, serum uric acid (UA) and (TAC) levels showed significant higher level in both breast cancer groups as compared to the benign group. However TOC levels showed only significantly higher level in metastatic group. Conclusions: The present study suggested elevated TAC, UA and TOC in breast cancer patients. The increased levels of trace elements could lead to formation of free radicals or other reactive oxygen species. The serum profile of these trace metals may be helpful in predicting prognosis of breast cancer.

Efficacy of New Mindfulness-Based Swinging Technique Intervention: A Pilot Randomised Controlled Trial Among Women With Breast Cancer

“…There were consistent findings from other randomised studies showing that there was an association between practicing mindfulness for 6 weeks (Lengacher et al, 2009;El-Deeb et al, 2016) or 8 weeks (Carlson and Garland, 2005) and improvement in the symptoms of depression and anxiety. However, Tang et al (2015) suggested that future research should focus on the length of the mindfulness interventions; the RCT study assessing the immediate efficacy of mindfulness practices are needed in the psycho-oncology literature.…”

Evaluation of Zinc, Copper, and Lead Levels in The Blood of Breast Cancer Women in Baghdad City

“…Conversely, El-Deeb et al found significantly higher serum zinc in the breast cancer groups as compared to the control group. The reason may be related to the variances in sample size and diet habits of subjects enrolled in both studies [20]. Moreover, the results presented in Table 3 are compatible with those of Pavithra et al, who found a statistically significant elevation in serum copper of patients with breast cancer when compared to controls [21].…”

Mindfulness-Based Stress Reduction on breast cancer symptoms: systematic review and meta-analysis

“…( 1 – 3 ) Currently, this is the second most common type of cancer affecting women, ( 4 , 5 ) accounting for 60% of the deaths in developed countries. ( 6 ) The incidence rate is increasing globally, for example, in 2008 approximately 1.38 million new cases of breast cancer were diagnosed ( 7 ) and 1.7 million in 2012, ( 8 , 9 ) with estimation of 1.38 to 1.7 million new cases each year, ( 10 , 11 ) which makes this chronic disease a major public health problem. ( 12 , 13 )…”