Evaluation of Zinc, Copper, and Lead Levels in The Blood of Breast Cancer Women in Baghdad City

Sahan, Enas J.

doi:10.24996/ijs.2022.63.1.1

Cited by 4 publications

(4 citation statements)

References 17 publications

(18 reference statements)

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“…Breast cancer is a complex disease that develops chemoresistance to conventional therapies, making it difficult to treat. This complexity manifested by the presence of imbalances in many elements may contribute to its development and progression [38]. There is need for precise diagnostic tools to guide treatment decisions [39].…”

Section: Discussionmentioning

confidence: 99%

The Effect of NF-κB Deactivation on Cancer Cell Response to ALA Mediated Photodynamic Therapy

Al-Khafaji,

Salman,

Hassan

et al. 2024

Asian Pac J Cancer Prev

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Objective: Breast cancer is one of the most widespread tumors among women worldwide, which is difficult to treat due to the presence of chemoresistance and the risk of tumor recurrence and metastasis. There is a pressing necessity to develop efficient treatments to improve response for treatment and increase prolong survival of breast cancer patients. Photodynamic therapy (PDT) has attracted interest for its features as a noninvasive and relatively selective cancer treatment. This method relies on light-activated photosensitizers that, upon absorbing light, generate reactive oxygen species (ROS) with powerful cell-killing outcomes. Nuclear factor kappa B (NF-κB), a transcription factor, plays a key role in cancer development by regulating cell proliferation, differentiation, and survival. Inhibiting NF-κB can sensitize tumor cells to chemotherapeutic agents. Dimethyl fumarate (DMF), an NF-κB inhibitor approved by the FDA for multiple sclerosis treatment, has further shown promise in suppressing breast cancer cell growth in vitro. We hypothesized that combining PDT with Dimethyl fumarate (DMF) could further enhance therapeutic efficacy for both treatment modalities. Methods: In the current study, we explored the PDT effect of 1 and 2 mM aminolaevulinic acid (ALA) and low-power He-Ne laser irradiation combined with different concentrations of DMF (2.5, 1.25, or 0.652 µg/ml) against hormone nonresponsive AMJ13 breast cancer cell line that is derived from Iraqi patient. Results: Our results demonstrated that co-administration with all tested DMF concentrations significantly enhanced the cytotoxicity of PDT antitumor effect. The combination index analysis showed presence of synergism in combining PDT with DMF. Conclusion: This finding suggests that the combination of PDT with DMF could be a promising novel strategy against triple negative breast cancer that could be applied clinically due to the fact that both of these treatments are already clinically approved therapies.

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Section: Discussionmentioning

confidence: 99%

The Effect of NF-κB Deactivation on Cancer Cell Response to ALA Mediated Photodynamic Therapy

Al-Khafaji,

Salman,

Hassan

et al. 2024

Asian Pac J Cancer Prev

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“…Breast cancer is the world's second-most common cancer and the most common cancer in women [1,2]. Given the excessive occurrence, early identification and the adoption of more powerful drug treatments can lessen mortality and enhance the exceptional lifestyles of humans with this condition [3,4].…”

Section: Introductionmentioning

confidence: 99%

Effect of s-Klotho Protein, GPX, Visfatin, Leptin and ROS of Iraqi Women with Breast Cancer

Ascar,

Fadhel

2024

Iraqi Journal of Science

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The most prevalent cancer is breast cancer, and the incidence of breast cancer in women worldwide is increasing at a remarkably rapid rate. This study was conducted on 90 samples (45 newly diagnosed breast cancer samples and 45 control group samples), ranging in age from 35 to 70 years. Blood samples were collected from the Alawia Teaching Hospital and the Oncology Teaching Hospital between October 2020 and March 2021. ELISA assessed ROS, GPX, visfatin, IGF-1, vitamin A, leptin, and soluble al-Klotho. The results indicate that the breast cancer patients had significantly higher (ROS 3.57, visfatin 17.44) (ng/mL) (p<0.0001) and leptin 16.11 (ng/mL). In the group of patients, there was a significant increase (p<0.004) compared with the control group, whereas there were no significant differences between IGF-1 (624.72 pg/mL) (p>0.507), s-Klotho 398.22 ng/L (p>0.653), and vitamin A 69.49 umol/L (p<0.05). The results showed a negative correlation among the levels of patients with BC (ROS and vitamin A, GPX, IGF-1, GPX, leptin, and vitamin A). Finally, the current study concludes that vitamin A deficiency is one of the important factors that may influence the clinical evolution and prognosis of patients with breast cancer. Moreover, it was shown that the higher levels of leptin and visfatin could increase the danger in BC cases. The study measured levels of leptin and visfatin, which can increase the danger in BC cases, and measured ROS in patients.

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“…A variety of methods have been used for this purpose, including liquid-ion exchange (LIE) [9,10], solvent extraction (SE) [11], flame atomic absorption spectroscopy (FAAS) [12], spectrophotometric study [13], liquid chromatography [14], kinetic spectrophotometry [15], and cloud point extraction (CPE) [16]. However, The CPE is a sensitive preconcentration and isolation procedure for abundant analytes with several advantages over traditional solvent extraction [17][18][19]. CPE is a quick, cost-effective, fast, precise, and selective process.…”

Section: Introductionmentioning

confidence: 99%

Separation and Micro Determination of Zinc(II) and Cadmium(II) in Food Samples Using Cloud Point Extraction method

Wannas

Azooz

Ridha

et al. 2023

Iraqi Journal of Science

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The cloud point extraction technique has become increasingly popular in recent years for trace metal separation and preconcentration. When heated to a specific temperature, cloud point extraction utilizes the property of nonionic surfactants in aqueous solutions to generate micelles and become turbid (so-called cloud point temperature). For analytical chemists, developing a simple and selective technology for the separation and determination of metals and medicinal drugs is a critical concern. Therefore, a sensitive, accurate, and green cloud point extraction (CPE) procedure was developed for the micro-determination of metal cations like zinc (II) and cadmium (II) in food samples. Triton X–114 and 1-(4-(Phenyldiazenyl) phenyl) azo naphthalene-2-ol (Sudan III) were used as extractants. Sudan III forms an ion-pair association complex with metal ions when the pH is 9. In the presence of 5 ppm zinc (II) or 4 ppm cadmium (II) in an aqueous solution, the maximum extraction efficiency should be achieved. In order to create Cloud Point Temperature (CPT) quantitatively, the extraction applications in this approach required heating at 85°C for 20 minutes. In this work, the impacts of different surfactants, pH, stoichiometry, and various organic reagents on interferences as well as spectrophotometric determination were explored. The linearity ranges of zinc (II) and cadmium (II) were 0.25-700 and 0.25-400 ppm, respectively. The results show low detection limits of 0.035 and 0.042 ppm for zinc (II) and cadmium (II), respectively. Also, the quantification limits for zinc (II) and cadmium (II) are 0.116 and 0.140 ppm, respectively.

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Evaluation of Zinc, Copper, and Lead Levels in The Blood of Breast Cancer Women in Baghdad City

Cited by 4 publications

References 17 publications

The Effect of NF-κB Deactivation on Cancer Cell Response to ALA Mediated Photodynamic Therapy

The Effect of NF-κB Deactivation on Cancer Cell Response to ALA Mediated Photodynamic Therapy

Effect of s-Klotho Protein, GPX, Visfatin, Leptin and ROS of Iraqi Women with Breast Cancer

Separation and Micro Determination of Zinc(II) and Cadmium(II) in Food Samples Using Cloud Point Extraction method

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