The current study was conducted on 100 females who were divided into two main groups; 60 with breast cancer and 40 healthy controls. Blood samples were collected from both premenopausal and postmenopausal breast cancer and healthy women. The samples were appropriately processed for the analysis of trace elements (zinc, copper, and lead) by using flame atomic absorption spectrophotometry (FAAS). The results showed a highly significant decrease (p< 0.01) in the mean serum level of zinc of in both pre- and postmenopausal breast cancer women (71.7 + 5.1 and 70.4 + 5.4 µg/dL, respectively) compared with healthy controls (89.7 + 10.2 and 97.5 + 13.2 µg/dL, respectively) . Also, a highly significant elevation (p< 0.01) in the mean serum level of copper (157.2 + 13.9 µg/dL and 157.4 +11.9 µg/dL, respectively) was found in pre- and postmenopausal breast cancer women as compared to healthy controls (122.2 + 15.5 µg/dL and 112.2 + 15.8 µg/dL, respectively). Furthermore, a highly significant elevation (p< 0.01) in the mean blood level of lead (20.7 + 2.5 µg/dL and 19.9 + 1.7 µg/dL, respectively) was found in pre- and postmenopausal breast cancer women compared to healthy controls (15.1 + 2.0 µg/dL and 14.6 + 2.3 µg/dL, respectively). It is concluded that the disturbance in the homeostasis of some trace elements (zinc, copper, and lead) may lead to the development and even progression of breast cancer in both pre- and postmenopausal women.
Objective:To Evaluate of Estradiol and Prolactin hormones levels for Breast Cancer women inBaghdad City.Methodology: The current study was conducted on 60 breast cancer women and 40 apparentlyhealthy subjects to evaluate the levels of estradiol and prolactin "hormones in the serum" of({premenopausal & postmenopausal}) breast cancer and healthy controle women. Estradiol andprolactin hormones estimated for all cases by using the IMMULITE 2000 instrument that performschemiluminescent immunoassays results are calculated for each sample.Data were analysed usingSPSS-18.data of two groups was comparison by the student's t-test.Results: The results showed a non significant""(P>0.05) elevation in the –mean- serum estradiol levelof the study (premenopausal &postmenopausal ) group (54.0 + 22.8 pg/ml),(31.6 + 9 pg/ml)respectively compared to that of control (pre& postmenopausal ) group (47.0 + 22.3 pg/ml), (28.4 +10.7 pg/ml) respectively.while a highly significant (P<0.01) elevation of serum prolactin (30.9 + 18.5ng/ml) ,(20.9 +15.2 ng/ml) respectively was found in study (premenopausal &postmenopausal ) groupcompared to healthy control (premenopausal &postmenopausal ) group (11.7 + 10.4" ng/ml"),(8.7 +5.1 "ng/ml") respectively.The results of this study indicate that the elevation of estradiol and prolactinhormones may implicate these hormones in the aetiology of" breast cancer"..Recommendations: This learn lines recommends emphasizing the necessity of cooperation betweenthe Ministry of Health and the Ministry of Commerce and protecting them from dangerous behavior byproviding them with sufficient support and guidance to stay away from the hormonic products andfocusing on the extension programs in the protection of the community through educating them withthe guidance programs
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