The role of serotonin in drug use and addiction

Müller, Christian P.; Homberg, Judith R.

doi:10.1016/j.bbr.2014.04.007

Cited by 258 publications

(185 citation statements)

References 734 publications

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“…El sustrato anatómico principal de este sistema es la vía mesolímbica que se origina en el área tegmental ventral (ATV) y se proyecta hacia el núcleo accumbens (NA) y diferentes lugares corticales que incluyen la corteza cingulada anterior (CCA), y la corteza orbitofrontal y prefrontal (Berridge y Kringelbach, 2015;Carlezon y Thomas, 2009;Dalley y Everitt, 2009;Wise, 2008). En estas áreas se libera el principal neurotransmisor relacionado con el refuerzo y el placer, la dopamina (Lammel, Lim y Malenka, 2014) pero también otros neurotransmisores como por ejemplo la serotonina (Müller y Homberg, 2015). Como comentá-bamos anteriormente, el refuerzo tiene diferentes componentes, como la experiencia subjetiva de placer o un componente relacionado con el aprendizaje o la capacidad de generar representaciones cognitivas con predicciones de adjudicación del refuerzo en el futuro.…”

Section: Refuerzo Y Adicciónunclassified

Modelos animales de adicción a las drogas

et al. 2017

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Resumen Abstract adicciones vol. 29, nº 4 · 2017 revisión Modelos animales de adicción a las drogas Animal Models of Drug AddictionMaría Pilar García Pardo*,**; Concepción Roger Sánchez*; José Enrique de la Rubia Ortí**; María Asunción Aguilar Calpe*. En los últimos años los modelos han incorporado modificaciones metodológicas para incluir el estudio de los procesos de extinción, reinstauración y reconsolidación o para modelar aspectos concretos de la conducta adictiva como puede ser la motivación para consumir la droga, el consumo compulsivo o la búsqueda de la droga bajo situaciones de castigo. Otros modelos interrelacionan diferentes componentes del refuerzo o modelan la motivación voluntaria por consumir (modelos de "two-bottle choice" o "drinking in the dark").En definitiva, las innovaciones en estos modelos contribuyen al avance en el conocimiento científico de los diferentes factores que llevan a tomar una droga y a desarrollar un consumo compulsivo, ofreciendo una vía para identificar futuros tratamientos para la adicción.Palabras clave: Refuerzo; Adicción; Modelos animales; Drogas de abuso.

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Section: Refuerzo Y Adicciónunclassified

Modelos animales de adicción a las drogas

et al. 2017

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“…Thereby, information is encoded within different behavioural systems, which can be summarized as "drug memories" [5,[7][8][9] (Box 1). It is believed that an intensification of these memories together with a loss of impulse control (compulsivity) is responsible for the transition from controlled drug use to addiction [10][11][12]. Understanding how these drug memories are established and how they may take control over a normal behavioural repertoire should, therefore, allow to improve the prevention of addiction and to develop new and more effective treatments [13].…”

Section: Drug Use and Addictionmentioning

confidence: 99%

“…Whether CaMK-dependent drug memories are stronger than normal memories and, therefore, induce a shift in behavioral repertoire from normal to addiction-related behaviors, is currently unclear. Other factors, like the loss of impulse control over established drug-related behaviors, are under serotonergic control [12], which is, in turn, CaMK dependent [129,132].…”

Section: Psychostimulantsmentioning

confidence: 99%

“…A lack of αCaMKII autophosphorylation may limit the capacity of transmitter available for release into the extracellular space upon excitation. This may lead to reduced 5-HT activation, which may account for the delay in the establishment of the rewarding effects of cocaine [12,67]. CaMKII binds to serotonin transporters (SERT) in neurons, but with lower affinity than to the DAT.…”

Section: Serotonin Activitymentioning

confidence: 99%

“…In the absence of a dopamine response, rewarding effects of psychoactive drugs can be mediated by the serotonergic system [12,83]. The lack of αCaMKII autophosphorylation enhanced basal serotonin (5-HT) levels in the NAc and PFC of mice.…”

Section: Serotonin Activitymentioning

confidence: 99%

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CaM Kinases: From Memories to Addiction

Müller

Quednow

Lourdusamy

et al. 2016

Trends in Pharmacological Sciences

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Drug addiction is a major psychiatric disorder with a neurobiological base that is still insufficiently understood. Initially, non-addicted, controlled drug consumption and drug instrumentalization are established. They comprise highly systematic behaviours acquired by learning and the establishment of drug memories. Ca 2+ /calmodulin-dependent protein kinases (CaMKs) are important Ca 2+ -sensors translating glutamatergic activation into synaptic plasticity during learning and memory formation. Here we review the role of CaMKs in the establishment of drugrelated behaviours in animal models and in humans. Converging evidence shows now that CaMKs are a crucial mechanism of how addictive drugs induce synaptic plasticity and establish various types of drug memories. Thereby, CaMKs are not only molecular relays for glutamatergic activity; they also directly control dopaminergic and serotonergic activity in the mesolimbic reward system. They can now be considered as major molecular pathways translating normal memory formation into establishment of drug memories and possibly transition to drug addiction. Keywords: Ca 2+/calmodulin-dependent protein kinase, drug dependence, addiction, psychostimulants, alcohol, opioids 3 Drug Use and AddictionDrug addiction is a major psychiatric disorder for which only limited therapies are currently available [1,2]. A striking criterion for drug abuse and addiction is that it severely threatens one's own and others well-being and health. As such, there is a persistent need to treat drug addiction effectively, and ideally reverse the behavioural repertoire of an affected individual back to normal.An important feature of drug addiction is that it develops from a behavioural repertoire, which is considered to be normal in many societies of the world: the controlled consumption and instrumentalization of psychoactive drugs [3,4].Establishing and maintaining controlled drug consumption is based on systematic learning and memory retrieval of distinct behaviours, related to drug seeking, preparation, and consumption in a specific context [5,6]. Thereby, information is encoded within different behavioural systems, which can be summarized as "drug memories" [5,[7][8][9] (Box 1). It is believed that an intensification of these memories together with a loss of impulse control (compulsivity) is responsible for the transition from controlled drug use to addiction [10][11][12]. Understanding how these drug memories are established and how they may take control over a normal behavioural repertoire should, therefore, allow to improve the prevention of addiction and to develop new and more effective treatments [13]. From Memories to Drug MemoriesIt was suggested that anatomical pathways, micro-morphological adaptations, as well as molecular mechanisms in the brain, overlap between normal learning and memory and drug memories [14][15][16]. A crucial player for memory formation in the brain is the glutamatergic system and its plasticity based on experience [17]. Addiction research considered glu...

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Association of Obsessive-Compulsive Disorder and Obsessive-Compulsive Symptoms With Substance Misuse in 2 Longitudinal Cohorts in Sweden

et al. 2022

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Key Points Question Do individuals with obsessive-compulsive disorder (OCD) or obsessive-compulsive symptoms have an elevated risk of substance misuse, and if so, to what extent do shared genetic and/or environmental factors account for their association? Findings This Swedish cohort study of 6 304 188 individuals from the general population and 9230 individuals in a separate twin cohort found that individuals with an OCD diagnosis had a 3.7-fold elevated risk of any substance misuse outcome. The association of OCD and obsessive-compulsive symptoms with substance misuse was partially attributed to shared genetics. Meaning These findings suggest that regular screening for substance use and problems should be included in routine clinical management of patients with OCD.

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The role of serotonin in drug use and addiction

Cited by 258 publications

References 734 publications

Modelos animales de adicción a las drogas

Modelos animales de adicción a las drogas

CaM Kinases: From Memories to Addiction

Association of Obsessive-Compulsive Disorder and Obsessive-Compulsive Symptoms With Substance Misuse in 2 Longitudinal Cohorts in Sweden

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