The role of resistance and aerobic exercise training on insulin sensitivity measures in STZ-induced Type 1 diabetic rodents

Hall, Katharine E.; McDonald, Matthew W.; Grisé, Kenneth N.; Campos, Oscar A.; Noble, Earl G.; Melling, C.W. James

doi:10.1016/j.metabol.2013.05.012

Cited by 55 publications

(52 citation statements)

References 50 publications

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“…Swim exercise training for 6 weeks was seen to reverse insulin resistance induced by aging in rats. These findings are in line with recent studies reported that exercise could ameliorate insulin resistance [43,44,45,46] . To understand the mechanisms underlying the impact of exercise on age-induced insulin resistance, serum levels of catecholamines, pro-inflammatory cytokines and TAC together with Glut4 mRNA expression level in skeletal muscles were assessed.…”

Section: Discussionsupporting

confidence: 93%

Exercise Training Prevents Age-induced Insulin Resistance in Rats: Effect on Circulating Catecholamines, Inflammatory Cytokines and Skeletal Muscle Glut4 Transporters

El-Gohary¹

2017

Am. J. Biomed. Sci.

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The incidence of insulin resistance increases with age. This work tested the effect of exercise on ageinduced insulin resistance and the possible involved mechanisms. Six groups of rats were used: 4 months old, 14 months old and 24 months old, either with and without exercise training. Swimming exercise training was performed 2h/day, 5days/week for 6 weeks. Insulin resistance was assessed by measuring serum glucose, serum insulin and homeostasis model assessment of insulin resistance (HOMA-IR) index. Serum levels of catecholamines, inflammatory cytokines and total antioxidant capacity (TAC) together with skeletal muscle Glut4 mRNA expression were assessed. Aged rats developed insulin resistance associated with increased serum catecholamines and inflammatory cytokine levels, decreased serum TAC and suppression of skeletal muscle Glut4 expressions. Exercise training reversed the developed insulin resistance and restored the values of catecholamines, inflammatory cytokines and skeletal muscle Glut4; however, it did not modify TAC. It was concluded that exercise could reverse aging-induced insulin resistance in rats by decreasing catecholamines and inflammatory cytokines production and also by increasing Glut4 expression in skeletal muscles.

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Section: Discussionsupporting

confidence: 93%

Exercise Training Prevents Age-induced Insulin Resistance in Rats: Effect on Circulating Catecholamines, Inflammatory Cytokines and Skeletal Muscle Glut4 Transporters

El-Gohary¹

2017

Am. J. Biomed. Sci.

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“…For example, white fibers are less affected by aerobic activity in terms of GLUT4 and insulin sensitivity. However, the results of present study are consistent with the findings of Durant (2002) increase of GLUT4 transportation to cell membrane (Paula et al, 2002), Caponi et al (2013) increase of GLUT4 (Caponi et al, 2013), Park et al, (2011) increase of GLUT4 (Park et al, 2011), Zarekar et al (2014) increase of GLUT4 and insulin sensitivity (Zarekar et al, 2014), andCatherine et al, (2013) increase of GLUT4 and improved insulin sensitivity (Katharine et al, 2013). The GLUT4 protein is a major mediator for glucose uptake from blood circulation which is expressed in skeletal muscle and adipose tissue (Huang and Czech, 2007).…”

Section: Discussionsupporting

confidence: 92%

Changes in blood insulin resistance, GLUT4 and AMPK after continuous and interval aerobic training in normal and diabetic rats

Afzalpour¹,

Yousefi²,

Eivari³

et al. 2016

J App Pharm Sci

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Objectives: Diabetes mellitus is now seen as a worldwide epidemic disease with prevalent and incidence data. Exercise training is known to promote beneficial changes in diabetic patient. Materials & Methods:A number of 60 male rats weighing 180 to 310 grams, 13 weeks old were divided into six groups. The exercise protocol was aerobic training for six weeks. In this study, factors like Insulin resistance, glucose transporter type 4 and AMP-activated protein kinase were measured. The data were analyzed using oneway analysis of variance test in P< 0.05 level. Results:The results showed a significant difference in insulin resistance (P=0.001, F5, 37= 10.80), Glucose transporter type 4 (P=0.001, F5, 37= 20.14) and AMP-activated protein kinase (F5, 37 = 16.2, P= 0.001) levels among different groups. There was no significant difference between the impact of continuous and interval training on these indices (P=1.00). Conclusions:The continuous and interval training by increasing the Glucose transporter type4 protein content and AMP-activated protein kinase lead to reduced blood glucose levels and improved insulin resistance. Furthermore, we could use conducting interval training as a therapeutic approach to manage diabetes for the participants who were not able to perform the continuous training due to fatigue.

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“…For induction of autoimmune type 1 DM, streptozotocin (STZ) was administered daily (i.p.) for 5 consecutive days at a dose of 20 mg/kg according to a previous study (Hall et al, 2013). STZ (Sigma-Aldrich, St. Louis, MO) were freshly dissolved in cold normal saline.…”

Section: Methodsmentioning

confidence: 99%

Antidiabetic potential of salvianolic acid B in multiple low-dose streptozotocin-induced diabetes

Raoufi

Baluchnejadmojarad

Roghani

et al. 2015

Pharmaceutical Biology

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Context: Salvianolic acids are the most abundant water-soluble compounds extracted from the herb Salvia miltiorrhiza L. (Lamiaceae) with antioxidant and protective effects. Objective: This study evaluates the antidiabetic effect of salvianolic acid B (Sal B) in multiple low-dose streptozotocin (MLDS)-induced diabetes in rat. Materials and methods: Rats were divided into control, Sal B40-treated control, diabetic, Sal B20-, and Sal B40-treated diabetic groups. Sal B was daily administered at doses of 20 or 40 mg/kg (i.p.), started on third day post-STZ injection for 3 weeks. Serum glucose and insulin level and some oxidative stress markers in pancreas were measured in addition to the oral glucose tolerance test (OGTT), histological assessment, and apoptosis determination. Results: After 3 weeks, treatment of diabetic rats with Sal B20 and Sal B40 caused a significant decrease of the serum glucose (p50.05-0.01) and improvement of OGTT. Meanwhile, serum insulin was significantly higher in Sal B20-and Sal B40-treated diabetics (p50.01) and treatment of diabetics with Sal B40 significantly lowered malondialdehyde (MDA) (p50.05), raised glutathione (GSH) (p50.05), and activity of catalase (p50.01) with no significant change of nitrite. Furthermore, the number of pancreatic islets (p50.05) and their area (p50.01) was significantly higher and apoptosis reactivity was significantly lower (p50.05) in the Sal B40-treated diabetic group versus diabetics. Discussion and conclusion: Three-week treatment of diabetic rats with Sal B exhibited antidiabetic activity which is partly exerted via attenuation of oxidative stress and apoptosis and augmentation of antioxidant system.

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The role of resistance and aerobic exercise training on insulin sensitivity measures in STZ-induced Type 1 diabetic rodents

Cited by 55 publications

References 50 publications

Exercise Training Prevents Age-induced Insulin Resistance in Rats: Effect on Circulating Catecholamines, Inflammatory Cytokines and Skeletal Muscle Glut4 Transporters

Exercise Training Prevents Age-induced Insulin Resistance in Rats: Effect on Circulating Catecholamines, Inflammatory Cytokines and Skeletal Muscle Glut4 Transporters

Changes in blood insulin resistance, GLUT4 and AMPK after continuous and interval aerobic training in normal and diabetic rats

Antidiabetic potential of salvianolic acid B in multiple low-dose streptozotocin-induced diabetes

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