The Role of Radiation in the Treatment of Advanced Juvenile Angiofibroma

Lee, Jivianne T.; Chen, Peter; Safa, Afshin; Juillard, Guy; Calcaterra, Thomas C.

doi:10.1097/00005537-200207000-00014

Cited by 92 publications

(94 citation statements)

References 39 publications

(89 reference statements)

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“…One source of confusion about effectiveness of radiotherapy as treatment for JNA arises from slow regression of this tumor after radiotherapy. The literature indicates that a residual but asymptomatic tumor is not necessarily uncontrolled and on continuing follow up, some of these residual masses may eventually disappear [6,8,18] This report reiterates that radiation therapy remains a viable option for the treatment of extensive JNA especially with signifi cant intracranial extension of the disease.…”

Section: Discussionmentioning

confidence: 82%

“…Although radiation has been reported to be an effective measure of therapy for JNA [1,5,6,7,8,9,10,11], potential long term complications have discouraged many from pursuing this course of therapy. Thyroid carcinoma, bone and soft tissue sarcomas, basal cell carcinoma, hypopituitarism, cataract, osteoradionecrosis, optic nerve, atrophy, osteomyelitis of skull base, facial growth retardation in maturing adolescents, all have been reported by various authors [6,[10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

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Complete resolution of stage IIIB juvenile nasopharyngeal angiofibroma with radiation therapy

Shunyu

Thakar

Gupta

2008

Indian J Otolaryngol Head Neck S

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Juvenile nasopharyngeal angiofi broma is a benign, locally aggressive, vascular tumour of adolescent males. Extension to intracranial cavity is not uncommon and presents diffi culties in management. Here we report a patient who had Radkowsky stage IIIB lesion, with blood supply from internal carotid artery. In view of anticipated problems with surgery, the patient was treated with 30 Gy in 15# external beam radiotherapy. On follow up, tumour was noted to disappear gradually overtime and at 3 years complete disappearance was noted with normal return of vision. Hence we are re-affi rming the earlier studies than angiofi broma mass regresses gradually after completion of radiotherapy. Radiotherapy is a useful way of treating angiofi broma with signifi cant intracranial extension.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Complete resolution of stage IIIB juvenile nasopharyngeal angiofibroma with radiation therapy

Shunyu

Thakar

Gupta

2008

Indian J Otolaryngol Head Neck S

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“…La cirugía endoscópica estaría indicada en estadios precoces, que no comprometan ampliamente la fosa infratemporal ni la base de cráneo 16,17 . Alternativamente al tratamiento quirúrgico está la radioterapia [18][19][20] .…”

Section: Introductionunclassified

Fibroangioma nasofaríngeo juvenil. Experiencia de 15 años en el Hospital Barros Luco Trudeau

et al. 2017

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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INTRODUCCIÓNEl Fibroangioma Nasofaríngeo Juvenil (FNJ) es una neoplasia vascular benigna, infrecuente, que se representa en el 0,05% a 0,5% de todos los tumores de cabeza y cuello 1 . Aunque histológicamente es benigno, en ocasiones su compleja localización anatómica, su tendencia a la invasión local, la recurrencia y su crecimiento agresivo, hacen que sea un tumor nasosinusal con características peculiares. Ocurre casi exclusivamente en la nasofaringe de adolescentes de sexo masculino 2,3 . Los FNJ tienen un crecimiento lento, centrado en el foramen esfenopalatino y se expanden dentro del la cavidad nasal, nasofaringe y luego en la fosa pterigomaxilar 4 . Eventualmente pueden erosionar el hueso e invadir la fosa infratemporal, órbita y fosa craneal media. La irrigación principal proviene de la arteria maxilar interna ipsilateral, pero además puede estar dada por la faríngea ascendente, maxilar interna contralateral o carótida interna. Los FNJ clásicamente se presentan con obstrucción nasal unilateral, epistaxis recurrente y tumoración nasal 5,6 . Existen otras manifestaciones clínicas según la extensión tumoral, tales como hipoacusia de conducción, proptosis ocular y hemorragia masiva 7 . En la evaluación inicial puede usarse la nasofibroscopía, tomografía computarizada y la resonancia nuclear magnética para determinar la extensión tumoral 8 . La tomografía computarizada es excelente para evaluar el compromiso óseo y extensión tumoral. El abombamiento de la pared posterior del maxilar debido a la presencia de la masa en el espacio pterigomaxilar, conocido como signo de Holman-Miller, es un hallazgo típico de este examen. La resonancia nuclear magnética permite evaluar los tejidos blandos y diferenciar el tumor de Inflamación de mucosa, lo cual es y esta es fundamental cuando existe compromiso intracraneano (Figura 1). Existe una variedad de clasificaciones de estos tumores 9-13 . La clasificación de Radkowski, desarrollada en 1996 es la más utilizada en la literatura en los últimos años (Tabla 1). Existen además otras clasificaciones como la de Fisch, Andrews y Sessions. Todas ellas se basan en la extensión e invasión de estructuras por el tumor, excepto la clasificación de la Universidad de Pittsburgh 14 que además incluye la vascularización residual posembolización. La cirugía es el tratamiento de primera elección. La embolización arterial supraselectiva preoperatoria de ramas de la carótida externa ha

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“…The treatment modality in JNA depends on the extent of the disease. For uncomplicated tumors without intracranial involvement, surgical resection is the treatment of choice [1][2][3]. For large tumors 1 2 with intracranial extension, the potential for surgical morbidity is very high because of their relation to major vasculature and cranial nerves at the base of the skull, and it may still leave residual disease needing postoperative RT [1][2]4].…”

Section: Introductionmentioning

confidence: 99%

“…For large tumors 1 2 with intracranial extension, the potential for surgical morbidity is very high because of their relation to major vasculature and cranial nerves at the base of the skull, and it may still leave residual disease needing postoperative RT [1][2]4]. The RT had been used as the primary modality of treatment for extensive lesions with good control rates with acceptable morbidity [1][2][4][5][6][7][8][9][10][11]. We present a case of advanced staged huge JNA that was treated by multisession CKRS with a volume fractionated technique.…”

Section: Introductionmentioning

confidence: 99%

Multisession Cyberknife radiosurgery for the treatment of advanced-stage intracranial extended Juvenile nasopharyngeal angiofibrom

Miyazaki¹,

Barrera²,

Sharma³

2011

Cureus

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The Role of Radiation in the Treatment of Advanced Juvenile Angiofibroma

Cited by 92 publications

References 39 publications

Complete resolution of stage IIIB juvenile nasopharyngeal angiofibroma with radiation therapy

Complete resolution of stage IIIB juvenile nasopharyngeal angiofibroma with radiation therapy

Fibroangioma nasofaríngeo juvenil. Experiencia de 15 años en el Hospital Barros Luco Trudeau

Multisession Cyberknife radiosurgery for the treatment of advanced-stage intracranial extended Juvenile nasopharyngeal angiofibrom

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