The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

Abstract

Pancreatitis is a gastrointestinal disease with a worldwide sharp surge during the past decade. Pancreatitis includes acute and chronic subtypes, which are graded based on the amount of pancreatic inflammation. Phytoconstituents represent a promising class of therapeutic agents with wide acceptability not only based on folk practices but sound presence of pharmacological and molecular evidences. Growing research evidence indicates that different molecular mechanisms are involved in their protective effect. Many phytoremedies have been tried for the treatment of pancreatic injuries and have shown success in preclinical animal models of pancreatitis. The literature was largely collected through PubMed and Google scholar database. A large proportion of phytochemicals targets the inflammatory cascade and modulates the overtly acting redox balance among which nuclear factor kappa-light-chain-enhancer of activated B cells is the key molecule. Inhibition of apoptosis (artemisinin, embelin), inflammasome (withaferin A), neutrophil rolling (fucoidan), Ca release (caffeine), mitogen activated protein kinase (guggulsterone) and many other novel mechanisms apart from antioxidant effect have been postulated behind the protective effect of phytoconstituents. The present review deals to fill the gap of hitherto unavailable comprehensive review on various plant products screened for the treatment of pancreatitis. The possible mechanistic profile of these phytochemicals is summarized. Copyright © 2017 John Wiley & Sons, Ltd.

Protective Effects of Anthocyanins from Coreopsis tinctoria against Oxidative Stress Induced by Hydrogen Peroxide in MIN6 Cells

“…Therefore, it is urgent to develop natural antioxidants as food additives or drugs to reduce oxidative stress. A large number of plant‐derived compounds have been explored, including polyphenols, terpenes, guanidines and flavonoids, for the treatment of a variety of pancreatic diseases, including diabetes mellitus . Vemana Gowd and the colleagues found that the antidiabetic effects of anthocyanins were attributed to their antioxidant capacity, which have been demonstrated in various organ.…”

“…A large number of plant-derived compounds have been explored, including polyphenols, terpenes, guanidines and flavonoids, for the treatment of a variety of pancreatic diseases, including diabetes mellitus. [13] Vemana Gowd and the colleagues found that the antidiabetic effects of anthocyanins were attributed to their antioxidant capacity, which have been demonstrated in various organ. Therefore, anthocyanins can be used as a potential drugs to prevent diabetes and associated complications.…”

Modulation of cerulein‐induced pancreatic inflammation by hydroalcoholic extract of curry leaf (Murraya koenigii)

“…Cerulein‐induced AP is a widely used model and closely resembles the human condition. A large number of phytoconstituents have been screened in this short model (Anchi et al, ). Curry leaves are natural flavoring agents and are widely used in Indian culinary recipes which gives the food an unmatched aroma.…”

“…Cerulein-induced AP is a widely used model and closely resembles the human condition. A large number of phytoconstituents have been screened in this short model (Anchi et al, 2017). (Samanta et al, 2017).…”

Rhubarb combined with trypsin inhibitor for severe acute pancreatitis: A systematic review and meta‐analysis

“…In recent years, cumulative clinical and experimental studies have shown that integrated traditional and Western medicine can significantly improve effectiveness (Anchi, Khurana, Bale, & Godugu, 2017). Rhubarb, as a traditional Chinese medicine, has been used for thousands of years.…”