Modulation of cerulein‐induced pancreatic inflammation by hydroalcoholic extract of curry leaf (<scp><i>Murraya koenigii</i></scp>)

Khurana, Amit; Sikha, Mary Swathi; Ramesh, Kethavath; Pooladanda, Venkatesh; Godugu, Chandraiah

doi:10.1002/ptr.6344

Cited by 22 publications

(11 citation statements)

References 55 publications

(75 reference statements)

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“…The collected blood was centrifuged and plasma was separated and stored at −80 C until further analysis. The amylase, lipase, SGOT, SGPT, ALP, and LDH levels were measured by following the instructions mentioned by the supplier (Anchi et al, 2018;Khurana, Sikha, Ramesh, Venkatesh, & Godugu, 2019).…”

Section: Estimation Of Various Biochemical Parameters In Plasmamentioning

confidence: 99%

Crocin, an active constituent of Crocus sativus ameliorates cerulein induced pancreatic inflammation and oxidative stress

Godugu

Pasari

Khurana

et al. 2019

Phytotherapy Research

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Acute pancreatitis (AP) is a disorder of the pancreas marked by profound inflammation and oxidative stress. Phytoconstituents presents an important toolbox of preventive strategies to combat inflammatory disorders. To this end, we selected the active constituent of Crocus sativus, crocin for evaluation against cerulein‐induced AP, owing to its promising antiinflammatory activity in acute as well as chronic inflammatory conditions. The animals were randomly divided into five groups comprising of normal control, cerulein control, crocin low dose (30 mg/kg), crocin high dose (100 mg/kg), and crocin control (100 mg/kg). Various biochemical parameters and the levels of inflammatory cytokines and p65‐NFκB were measured. The mechanism was investigated by histology and immunohistochemistry. We found that crocin significantly reduced the pancreatic edema, amylase, and lipase levels. It abrogated the oxidative stress incurred by cerulein challenge. We found that crocin modulated the pancreatic inflammatory cytokine levels. Crocin perturbed the nuclear translocation of p65‐NFκB. Crocin reverted the pancreatic histology associated with AP. Furthermore, it upregulated the expression of Nrf‐2 and downregulated the expression of IL‐6, TNF‐α, nitrotyrosine, and NFκB. Cumulatively, these results indicate that crocin has promising potential to prevent cerulein induced AP and regular intake of saffron can prove beneficial for the pancreatic health.

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Section: Estimation Of Various Biochemical Parameters In Plasmamentioning

confidence: 99%

Crocin, an active constituent of Crocus sativus ameliorates cerulein induced pancreatic inflammation and oxidative stress

Godugu

Pasari

Khurana

et al. 2019

Phytotherapy Research

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“…Plants contain a promising amount of antioxidants to protect and preserve their physical and metabolic integrity [3]. Murraya koenigii, which is commonly known as curry leaf, is commonly used as a natural flavouring agent because of its aromatic scent and medicinal value [4,5]. M. koenigii belongs to the Rutaceae family, which is native in Malaysia, India and other South Asian countries [6].…”

Section: Introductionmentioning

confidence: 99%

Hybrid Drying of Murraya koenigii Leaves: Energy Consumption, Antioxidant Capacity, Profiling of Volatile Compounds and Quality Studies

et al. 2020

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This study aims to reduce the amount of specific energy consumed during the drying of fresh Murraya koenigii leaves by comparing four drying methods: (1) convective hot-air drying (CD; 40, 50 and 60 °C); (2) single-stage microwave-vacuum drying (MVD; 6, 9 and 12 W/g); (3) two-stage convective hot-air pre-drying followed by microwave-vacuum finishing–drying (CPD-MVFD; 50 °C, 9 W/g); and (4) freeze-drying as a control in the analysis sections. The drying kinetics were also modelled using thin-layer models. The quality parameters of dried M. koenigii leaves were measured including total polyphenolic content (TPC), antioxidant capacity (ABTS and FRAP), profiling of volatile compounds, colour analysis and water activity analysis. Results showed that CPD-MVFD effectively reduced the specific energy consumption of CD at 50 °C by 67.3% in terms of kilojoules per gram of fresh weight and 48.9% in terms of kilojoules per gram of water. The modified Page model demonstrated excellent fitting to the empirical data obtained. FD showed promising antioxidant activity. The major contributor of antioxidant capacity was TPC. The volatile compounds profiled by gas chromatography-mass spectrometry, namely, β-phellandrene (31%), α-pinene (19.9%), and sabinene (16%) were identified as the major compounds of dried M. koenigii leaves. Colour analysis showed MVD’s high performance in preserving the colour parameters of M. koenigii leaves under all conditions. The colour parameters were correlated to the antioxidant capacity and TPC. Water activity analysis showed that the water activity of M. koenigii leaves for all drying methods indicating that the conditions were microbiologically and shelf-stable. Pearson correlation showed the colour parameters of the leaves had a strong correlation to TPC. Overall, MVD showed promising energy consumption reduction and recovery in TPC and volatile compounds.

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“…The activity of inflammatory cytokines interleukin 1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor (TNF-α), and p65-NFκB was significantly reduced by the hydroalcoholic extract of M. koenigii. In addition, the hydroalcoholic extract of M. koenigii reduced the expression of nitrotyrosine (NT), myeloperoxidase (MPO), IL-1β, intercellular adhesion molecule 1 (ICAM-1), and cyclooxygenase (COX-2), and increased the expression of Nrf2 [92]. Iman et al evaluated the anti-inflammatory activity of an extract of M. koenigii and its bioactive compound girinimbine against lipopolysaccharide/interferon-gamma-induced RAW 264.7 cells.…”

Section: Inflammationmentioning

confidence: 99%

Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds

Balakrishnan

Vijayraja²,

et al. 2020

Antioxidants

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The discovery of several revitalizing molecules that can stop or reduce the pathology of a wide range of diseases will be considered a major breakthrough of the present time. Available synthetic compounds may provoke side effects and health issues, which heightens the need for molecules from plants and other natural resources under discovery as potential methods of replacing synthetic compounds. In traditional medicinal therapies, several plant extracts and phytochemicals have been reported to impart remedial effects as better alternatives. Murraya koenigii (M. koenigii) belongs to the Rutaceae family, which is commonly used as a medicinally important herb of Indian origin in the Ayurvedic system of medicine. Previous reports have demonstrated that the leaves, roots, and bark of this plant are rich sources of carbazole alkaloids, which produce potent biological activities and pharmacological effects. These include antioxidant, antidiabetic, anti-inflammatory, antitumor, and neuroprotective activities. The present review provides insight into the major components of M. koenigii and their pharmacological activities against different pathological conditions. The review also emphasizes the need for more research on the molecular basis of such activity in various cellular and animal models to validate the efficacy of M. koenigii and its derivatives as potent therapeutic agents.

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Modulation of cerulein‐induced pancreatic inflammation by hydroalcoholic extract of curry leaf (Murraya koenigii)

Cited by 22 publications

References 55 publications

Crocin, an active constituent of Crocus sativus ameliorates cerulein induced pancreatic inflammation and oxidative stress

Crocin, an active constituent of Crocus sativus ameliorates cerulein induced pancreatic inflammation and oxidative stress

Hybrid Drying of Murraya koenigii Leaves: Energy Consumption, Antioxidant Capacity, Profiling of Volatile Compounds and Quality Studies

Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds

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