The role of peroxidases in the pathogenesis of atherosclerosis

Abstract

Reactive oxygen species (ROS),

Choroidal Vessel Wall: Hypercholesterolaemia-Induced Dysfunction and Potential Role of Statins

“…The EC, macrophages, and VSMC are targets for ROS-dependent atherogenic signalling [81]. Our data suggest that changes in arterial ROS production may occur very early in hypercholesterolaemia.…”

Increased expression of interleukin-1β in triglyceride-induced macrophage cell death is mediated by p38 MAP kinase

“…Atherosclerosis is a complex vascular disease and causes cardiac cell death and myocardial infarction through endothelial activation, cellular influx, and production of mediators and cytokines (1)(2)(3)(4). A characteristic feature of atherosclerosis is the migration of macrophages to the lesion to become foam cells, which in turn, accelerate the progression of atherosclerotic lesions (2,3,5,6).…”

Oxidative modification of ferritin induced by methylglyoxal

“…In some biological cells, cleavage of metalloproteins through oxidative damage may lead to increased in levels of metal ions (22,23). This mechanism produces ROS and may be involved in pathological conditions such as type 2 diabetes mellitus, atherosclerosis and neurodegenerative disorders (25)(26)(27)(28).…”