The Role of Periodontitis and Periodontal Bacteria in the Onset and Progression of Alzheimer’s Disease: A Systematic Review

Dioguardi, Mario; Crincoli, Vito; Laino, Luigi; Alovisi, Mario; Sovereto, Diego; Mastrangelo, Filiberto; Russo, Lucio Lo; Muzio, Lorenzo Lo

doi:10.3390/jcm9020495

Cited by 128 publications

(99 citation statements)

References 88 publications

(96 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Worldwide, it affects up to 60% of the population [8,9]. There appears to be an association of periodontitis with certain systemic diseases such as cardiovascular disease, complications in pregnancy or Alzheimer's disease [10,11]. The pathogenesis of periodontal diseases is mediated by the inflammatory response of the host to the bacteria in the subgingival plaque [12].…”

Section: Introductionmentioning

confidence: 99%

Tolerance and Persister Formation in Oral Streptococci

et al. 2020

View full text Add to dashboard Cite

The aim of this study was to analyze the potential influence of long-term exposure in subinhibitory concentrations of chlorhexidine on the emergence of tolerant and/or persistent cells in oral streptococci. The two oral streptococcal isolates S. mutans ATCC25175 and S. sobrinus ATCC33402 were incubated, after long-term subinhibitory exposure to chlorhexidine, in liquid growth media containing high concentrations of chlorhexidine. A distinct subpopulation of more chlorhexidine-tolerant cells could be detected in streptococci that had been previously exposed to subinhibitory concentrations of chlorhexidine but not in the control strains. These more biocide-tolerant and persisting microbial subpopulations might also arise in vivo. Therefore, the rational and proper use of antimicrobials in dentistry, especially when used over a long period of time, is crucial.

show abstract

Section: Introductionmentioning

confidence: 99%

Tolerance and Persister Formation in Oral Streptococci

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The interplay between periodontitis and systemic inflammation is well documented [42,43]. A recent systematic review confirmed that periodontal bacterial load and gum inflammatory burden can intensify the neuroinflammation in the central nervous system in Alzheimer's disease (AD), favoring the onset and progression of this neurodegenerative condition [44]. Accumulating evidence has shed light on how neuroinflammation can play a key role on the PD pathogenesis and neurodegeneration [45,46].…”

Section: Discussionmentioning

confidence: 99%

Parkinson’s Disease, Periodontitis and Patient-Related Outcomes: A Cross-Sectional Study

et al. 2020

View full text Add to dashboard Cite

Background and objectives: People with Parkinson’s disease (PD) may be at risk of having bad periodontal status. A consistent periodontal examination is critical to investigate how it impacts on PD quality of life. We aimed to assess the periodontal status of people with PD, and its association with quality of life and self-perceived xerostomia. Materials and Methods: To this end, from February to March 2020, we consecutively enrolled 28 PD individuals, and motor and non-motor symptoms of PD were assessed using the Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). We performed full-mouth periodontal examination and gathered information on self-perceived quality of life in PD, oral health impact profile (OHIP-14) and xerostomia. Results: The prevalence of periodontitis was 75.0% and most cases were identified as severe (46.4%). Upper extremity rigidity, hand posture and kinetic tremors were significantly correlated with worse periodontal status. PDQ-8 showed to be correlated with self-perceived oral health-related quality of life and xerostomia levels. Conclusions: This group of people with PD had a high prevalence of periodontitis. Deteriorated levels of the upper extremities in advanced stages of PD were associated with worse periodontal status and hygiene habits. Quality of life in PD appears to be associated with self-perceived OHRQoL and xerostomia.

show abstract

“…The following review was performed on the basis of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) [25] indications. The methodology has already been adopted in other systematic reviews on the topic (Actinomyces and Propionibacterium) by the same authors [26][27][28].…”

Section: Methodsmentioning

confidence: 99%

Microbial Association with Genus Actinomyces in Primary and Secondary Endodontic Lesions, Review

et al. 2020

Self Cite

View full text Add to dashboard Cite

The main reason for root canal treatment failure is the persistence of microorganisms after therapy, or the recontamination of the root canal system due to an inadequate seal. In the mouth, Actinomyces spp. constitute a significant part of the normal flora, which is indicative of their ability to adhere to oral tissue and resist cleansing mechanisms, such as salivary flow. This review, performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), aims to clarify the prevalence of microbial genera that are associated with the genus Actinomyces in primary and secondary endodontic infections (primary outcome), and to identify the most prevalent species of the Actinomyces genus in endodontic lesions (secondary outcome). A total of 11 studies were included in the qualitative and quantitative analysis, and a total of 331 samples were analyzed. Bacteria of the genus Actinomyces were found in 58 samples, and 46 bacterial genera were detected in association with bacteria of the genus Actinomyces. Bacteria of the genus Streptococcus and Propionibacterium were those most frequently associated with Actinomyces in the endodontic lesions considered, and Actinomyces israelii was the most frequently involved species.

show abstract

The Role of Periodontitis and Periodontal Bacteria in the Onset and Progression of Alzheimer’s Disease: A Systematic Review

Cited by 128 publications

References 88 publications

Tolerance and Persister Formation in Oral Streptococci

Tolerance and Persister Formation in Oral Streptococci

Parkinson’s Disease, Periodontitis and Patient-Related Outcomes: A Cross-Sectional Study

Microbial Association with Genus Actinomyces in Primary and Secondary Endodontic Lesions, Review

Contact Info

Product

Resources

About