The Role of Oxidative Stress and Antioxidants in Diabetic Complications = دور الإجهاد التأكسدي و المواد المضادة للأكسدة في مضاعفات مرض السكري

Matough, Fatmah Ali; Budin, Siti Balkis; Hamid, Zariyantey Abd; Alwahaibi, Nasar; Mohamed, Jamaludin

doi:10.12816/0003082

Cited by 463 publications

(70 citation statements)

References 99 publications

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“…It is rational in the absence of insulin, cells, especially skeletal muscle cells cannot use glucose and consume intracellular proteins as energy sources. The importance of oxidative stress in the pathogenesis and DM complications is well studied and documented (Giacco & Brownlee, 2010;Matough et al, 2012). Increasing free radicals generation and high level of oxidative stress due to depletion of the activity of free radical scavenging enzymes caused by chronic hyperglycemia exhibited in both human and experimental animal models of diabetes (Giacco & Brownlee, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Many factors are involved in the pathogenesis of diabetes mellitus and its complications (Lipinski, 2001;Yang, Jin, Lam, Wai, & Yan, 2011) and one of the most important is oxidative stress. Oxidative stress refers to the excessive generation of free radicals and depletion of free radical scavenging enzymes that have been demonstrated in animals and in human subjects with diabetes mellitus (Matough, Budin, Hamid, Alwahaibi, & Mohamed, 2012). Formation of reactive oxygen species (ROS) leads to β-cell dysfunction initiated by inflammatory cytokines and autoimmune reactions in type 1 of DM (Cernea & Dobreanu, 2013;Matough et al, 2012).…”

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confidence: 99%

“…Oxidative stress refers to the excessive generation of free radicals and depletion of free radical scavenging enzymes that have been demonstrated in animals and in human subjects with diabetes mellitus (Matough, Budin, Hamid, Alwahaibi, & Mohamed, 2012). Formation of reactive oxygen species (ROS) leads to β-cell dysfunction initiated by inflammatory cytokines and autoimmune reactions in type 1 of DM (Cernea & Dobreanu, 2013;Matough et al, 2012). In type 2 DM, β cell apoptotic pathways, impair insulin synthesis and also insulin resistance is activated by ROS formation (Cernea & Dobreanu, 2013).…”

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Cyclohexane extract of walnut leaves improves indices of oxidative stress, total homocysteine and lipids profiles in streptozotocin‐induced diabetic rats

et al. 2020

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This study aimed to evaluate the effect of two doses of cyclohexane extract of walnut leaves on total homocysteine, lipids profiles, and indices of oxidative stress including superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), and malondialdehyde (MDA) in diabetic rats. Diabetes was induced by a single intraperitoneal (IP) injection of streptozotocin (50 mg/kg BW). Twenty‐eight male Sprague Dawley rats were randomly divided into four groups, group I: control (received sesame oil as vehicle), group II: diabetic control (received sesame oil), group III and IV: diabetic rats treated by 150 and 250 mg/kg body weight (BW) per day extract of walnut leaves, respectively. All groups were treated for 28 days via oral gavage. Fasting blood glucose (FBG) level and body weight measured before injection, 3 days after injection, and on days 0, 7, 14, 21, and 28 of treatment. At the end the 28th day of the experiment, blood samples collected via heart puncture and the sera were used for estimation of the above‐mentioned parameters. The results showed a decrease in FBS, TC, TG, LDL‐c, VLDL‐c, homocysteine, and MDA level and increase in the level of HDL‐c in diabetics treated by walnut leave extracts in a dose‐dependent manner after 28 days. The activity of antioxidant enzymes significantly increased in treated groups compared with diabetic control. It can be concluded that cyclohexane extract of walnut leaves has an overall beneficial effect on body weight, fasting blood glucose, lipids profile, antioxidant enzyme activities, and homocysteine.

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Section: Discussionmentioning

confidence: 99%

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Cyclohexane extract of walnut leaves improves indices of oxidative stress, total homocysteine and lipids profiles in streptozotocin‐induced diabetic rats

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“…In addition, many chronic diseases such as T2DM have been linked to oxidative stress which involves the production of reactive oxygen species (ROS) such as superoxide anion radical (O 2 − ), hydrogen peroxide (H 2 O 2 ) and hydroxyl radical (OH − ). The role of free radicals in the pathogenesis and progression of diabetes is confirmed by an increase in the concentration of malondialdehyde (MDA) by lipid peroxidation in the pancreatic tissue of diabetic animal models [6]. Thus, compounds that have both antidiabetic and antioxidant activities, without causing serious adverse effects, would be beneficial.…”

Section: Introductionmentioning

confidence: 99%

Alpha-Amylase and Alpha-Glucosidase Enzyme Inhibition and Antioxidant Potential of 3-Oxolupenal and Katononic Acid Isolated from Nuxia oppositifolia

et al. 2019

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Nuxia oppositifolia is traditionally used in diabetes treatment in many Arabian countries; however, scientific evidence is lacking. Hence, the present study explored the antidiabetic and antioxidant activities of the plant extracts and their purified compounds. The methanolic crude extract of N. oppositifolia was partitioned using a two-solvent system. The n-hexane fraction was purified by silica gel column chromatography to yield several compounds including katononic acid and 3-oxolupenal. Antidiabetic activities were assessed by α-amylase and α-glucosidase enzyme inhibition. Antioxidant capacities were examined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) scavenging assays. Further, the interaction between enzymes (α-amylase and α-glucosidase) and ligands (3-oxolupenal and katononic acid) was followed by fluorescence quenching and molecular docking studies. 3-oxolupenal and katononic acid showed IC50 values of 46.2 μg/mL (101.6 µM) and 52.4 μg/mL (119.3 µM), respectively against the amylase inhibition. 3-oxolupenal (62.3 µg/mL or 141.9 μM) exhibited more potent inhibition against α-glucosidases compared to katononic acid (88.6 µg/mL or 194.8 μM). In terms of antioxidant activity, the relatively polar crude extract and n-butanol fraction showed the greatest DPPH and ABTS scavenging activity. However, the antioxidant activities of the purified compounds were in the low to moderate range. Molecular docking studies confirmed that 3-oxolupenal and katononic acid interacted strongly with the active site residues of both α-amylase and α-glucosidase. Fluorescence quenching results also suggest that 3-oxolupenal and katononic acid have a good affinity towards both α-amylase and α-glucosidase enzymes. This study provides preliminary data for the plant’s use in the treatment of type 2 diabetes mellitus.

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“…61 Redoks mekanizmasında bir dengesizlik oluşumu, diyabetin ve komplikasyonlarının patogenezine katkıda bulunabilmektedir. 62 Son zamanlarda yapılan çalışmalar, diyabetli bireylerde plazma bakır seviyesinin sağlıklı bireylere göre daha yüksek olduğunu belirtmektedir. 20,22,63 Viktorinova ve ark.nın çalışmasında, diyabetik hastalarda bakır seviyesinin ve bakır/çinko oranının artığı, bakır seviyesi ve bakır/çinko oranı arasında pozitif yönde bir korelasyon olduğu belirtilmiştir.…”

Section: Bakir Ve Di̇abetes Melli̇tusunclassified

Minerals and Diabetes Mellitus

Gülbaran¹,

Çelik²

2019

Turkiye Klinikleri J Intern Med

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gibi birtakım minerallerin dolaşımdaki seviyeleri diyabet için önemli bir prediktör olabilmekte ve suplementasyonları diyabetik bireylerin sağlık durumlarında yararlı etkiler oluşturabilmektedir. Glukoz homeostazı pankreasın beta hücrelerinden salgılanan insülin hormonunun kontrolü ve koordinasyonu ile sağlanmaktadır. Vücuttaki insülinin üretilememesi veya kullanılamaması durumunda kan glukoz homeostazında bozulmalar meydana gelmekte ve vücuttan bazı minerallerin aşırı atılımı gerçekleşebilmektedir. Aşırı atılım ile gereksinimin artması sonucu glukoz metabolizma yolağında, beta hücre fonksiyonunda ve insülin sinyalizasyon kaskadında bozulmalar meydana gelebilmekte ve bu durum diyabet ve komplikasyonlarının patogenezine katkı sağlayabilmektedir. Bu çalışmada, bazı minerallerin vücuttaki seviyelerinin ve yapılan süplementasyonların diyabet ile ilişkisinin değerlendirilmesi amaçlanmıştır. Bu noktada, odaklandığımız mineraller; çinko, bakır, krom, magnezyum, mangan, bakır, demir, selenyum ve vanadyumdur. Yapılan çalışmalardan elde edilen sonuçlar, vücut mineral düzeyinin diyabet ile ilişkisinde bazı farklılıklar ortaya koymaktadır. Ayrıca, diyabetin önlenmesi veya yönetiminde mineral süplementasyonunun yeterli kanıtlar sağlayamadığını göstermektedir. Diyabet ve komplikasyonları açısından risk altında olan bireylerde dolaşımdaki mineral düzeyinin ve mineral süplementasyonun gerekliliğinin saptanması oldukça önemlidir ve bu noktada daha büyük örnekli ve daha uzun süreli takip gerektiren çalışmalarla desteklenen kanıtlara gereksinim duyulmaktadır.A An na ah ht ta ar r K Ke el li im me el le er r: : Mineraller; diabetes mellitus; kan glukozu A AB BS ST TR RA AC CT T Minerals take an important role in electrolyte balance, preservation and maintenance of bone tissue, blood clotting, and regulation of nerve conduction as well as role as enzyme cofactor in various physiological reactions in metabolism. Circulating levels of a number of minerals, such as zinc, chromium, magnesium, manganese, selenium, may be an important predictor for diabetes, and their supplementation may have beneficial effects on the health status of diabetic individuals. Glucose homeostasis is provided by the control and coordination of insulin hormone secreted from beta cells of the pancreas. In the event that the insulin in the body cannot be produced or used, disruption of blood glucose homeostasis occurs and excessive excretion of some minerals from the body may occur. As a result of increased requirement with excessive excretion, in the glucose metabolism pathway, in beta-cell function and insulin signaling cascade may occur impairments and this occasion may contribute to the pathogenesis of diabetes and its complications. The aim of this review evaluate the relationship between levels and/or supplement of minerals and diabetes mellitus. At this point we focus on zinc, copper, chromium, magnesium, manganese, copper, iron, selenium and vanadium. The results obtained from the studies show some differences in the relationship of body mineral level and ...

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The Role of Oxidative Stress and Antioxidants in Diabetic Complications = دور الإجهاد التأكسدي و المواد المضادة للأكسدة في مضاعفات مرض السكري

Cited by 463 publications

References 99 publications

Cyclohexane extract of walnut leaves improves indices of oxidative stress, total homocysteine and lipids profiles in streptozotocin‐induced diabetic rats

Cyclohexane extract of walnut leaves improves indices of oxidative stress, total homocysteine and lipids profiles in streptozotocin‐induced diabetic rats

Alpha-Amylase and Alpha-Glucosidase Enzyme Inhibition and Antioxidant Potential of 3-Oxolupenal and Katononic Acid Isolated from Nuxia oppositifolia

Minerals and Diabetes Mellitus

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