2019
DOI: 10.3390/biom10010061
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Alpha-Amylase and Alpha-Glucosidase Enzyme Inhibition and Antioxidant Potential of 3-Oxolupenal and Katononic Acid Isolated from Nuxia oppositifolia

Abstract: Nuxia oppositifolia is traditionally used in diabetes treatment in many Arabian countries; however, scientific evidence is lacking. Hence, the present study explored the antidiabetic and antioxidant activities of the plant extracts and their purified compounds. The methanolic crude extract of N. oppositifolia was partitioned using a two-solvent system. The n-hexane fraction was purified by silica gel column chromatography to yield several compounds including katononic acid and 3-oxolupenal. Antidiabetic activi… Show more

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Cited by 173 publications
(145 citation statements)
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“…Due to its major role in the breakdown of polysaccharides, alpha-amylase is considered one of the most important enzymes in the digestion process found primarily in the saliva and pancreatic juice [ 26 ]. Targeting this enzyme and inhibiting it is one of the possible solutions to prevent high postprandial blood glucose [ 27 ].…”
Section: Resultsmentioning
confidence: 99%
“…Due to its major role in the breakdown of polysaccharides, alpha-amylase is considered one of the most important enzymes in the digestion process found primarily in the saliva and pancreatic juice [ 26 ]. Targeting this enzyme and inhibiting it is one of the possible solutions to prevent high postprandial blood glucose [ 27 ].…”
Section: Resultsmentioning
confidence: 99%
“…Phenolic compounds prevent the enzymatic hydrolysis of carbohydrates by inhibiting α-amylase and α-glucosidase, with a mixed mechanism (competitive and uncompetitive) [ 20 ]. Previous studies using in vitro and in vivo testing [ 21 , 22 , 23 ] demonstrated an antidiabetic activity from the rhizome extracts of C. orchioides and C. latifolia . However, in this work, we found that only the rhizome of C. latifolia showed high antioxidant activity and potent inhibition of α-glucosidase enzyme associated with the high phenolic compounds in plants.…”
Section: Discussionmentioning
confidence: 99%
“…Important carbohydrate-hydrolysing enzymes such as α-amylase, and α-glucosidase enzymes play key roles in the breakdown of starch, oligosaccharides and disaccharides into monosaccharides for absorption [4,5]; and thereby serve as key targets for phytomedicines towards suppressing carbohydrate digestion, and delaying glucose uptake in the gut [6]. In practice, several synthetic drugs such as acarbose, voglibose, and miglitol are potent inhibitors of carbohydrate-hydrolysing enzymes; however, these drugs are associated with undesirable effects such as bloating, abdominal discomfort, diarrhea, and flatulence [7]. Utilizing natural antidiabetic agents, which can constrain carbohydrate metabolizing enzymes in human gut, is a promising oral policy for blunting postprandial plasma glucose rise; and alleviating diabetes, obesity, and other metabolic syndromes [8,9].…”
Section: Introductionmentioning
confidence: 99%