The Role of Osteopontin on Calcium Oxalate Crystal Formation

Konya, Eiji; Umekawa, Tohru; Iguchi, Masanori; Kaburagi, Takashi

doi:10.1016/s0302-2838(03)00088-5

Cited by 54 publications

(54 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mg 2 þ and OPN play essential roles in the CaOx crystalcell interaction (Konya et al, 2003). Mg 2 þ could act as an inhibitor of crystal formation (Lieske, Farell and Deganello, 2004) while the possible role of OPN in kidney stone formation is inhibition of calcium oxalate monohydrate (COM) nucleation and reduction of the growth and aggregation of CaOx crystals (Khan et al, 2002;Yasui et al, 2002;Prat et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Prophylactic effects of Orthosiphon stamineus Benth. extracts on experimental induction of calcium oxalate nephrolithiasis in rats

Zhong

Ying

et al. 2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Prophylactic effects of Orthosiphon stamineus Benth. extracts on experimental induction of calcium oxalate nephrolithiasis in rats

Zhong

Ying

et al. 2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…Although they attribute this to surface expression of hyaluronic acid in less mature cultures, it may be significant that OPN was also expressed at the surface of proliferating cells. Koyna et al [18]have demonstrated increased adherence and aggregation of CaOx seed crystals to OPN-coated collagen granules. Thus, it appears that OPN immobilized on surfaces may increase CaOx adherence and, in solution, inhibit it.…”

Section: Opn and Crystal Formation In Vitromentioning

confidence: 99%

Osteopontin and Calcium Stone Formation

2004

View full text Add to dashboard Cite

Osteopontin (OPN) is a phosphorylated protein of wide tissue distribution that is found in association with dystrophic calcification including in the organic matrix of kidney stones. It is a strong inhibitor of crystal formation and growth in vitro, but there is still debate regarding its effects upon crystal adhesion to tubular epithelial cells. In this brief review, we will outline the evidence implicating OPN in stone disease with the primary emphasis being on the interaction of OPN with calcium oxalate (CaOx), the major constituent of calcium containing stones. Finally, preliminary data is presented regarding the amounts and features of OPN present in the urine of stone formers and normal individuals.

show abstract

“…For this reason, in such industries, alternative additives preventing the occurrence of calcium oxalate deposition are needed. On the other hand, calcium oxalate is the primary constituent of more than 60% of the majority of human kidney stones which are aggregates [7].…”

Section: Introductionmentioning

confidence: 99%

Calcium oxalate crystallization in the presence of amino acids, proteins and carboxylic acids

Sayan¹,

Titiz‐Sargut

Kıran

2009

Cryst. Res. Technol.

View full text Add to dashboard Cite

Reactive crystallization of calcium oxalate was investigated in the presence of amino acids, proteins and carboxylic acids at different pH and temperatures. Average particle size, filtration rates of calcium oxalate crystals obtained in the absence and presence of additives were determined. The influence of pH, temperatures and additives on crystal morphology of calcium oxalate were also investigated and discussed by SEM analysis. TG-DTA, FT/IR and XRD analysis were carried out for all investigated conditions. Average particle size of calcium oxalate was affected significantly by the additive type and concentration. Variation of crystal morphology depending on type and concentration of the additives affected the filtration characteristics. Majority of calcium oxalate crystals occurred in the form of calcium oxalate monohydrate except those in the presence of tartaric acid. TG-DTA, FT/IR and XRD analysis proved that calcium oxalate monohydrate and calcium oxalate dihydrate mixtures are formed in the presence of tartaric acid. The effect of all additives on scale formation was also investigated.

show abstract

The Role of Osteopontin on Calcium Oxalate Crystal Formation

Cited by 54 publications

References 31 publications

Prophylactic effects of Orthosiphon stamineus Benth. extracts on experimental induction of calcium oxalate nephrolithiasis in rats

Prophylactic effects of Orthosiphon stamineus Benth. extracts on experimental induction of calcium oxalate nephrolithiasis in rats

Osteopontin and Calcium Stone Formation

Calcium oxalate crystallization in the presence of amino acids, proteins and carboxylic acids

Contact Info

Product

Resources

About