The Role of Multilayer Electrospun Poly(Vinyl Alcohol)/Gelatin nanofibers loaded with Fluconazole and Cinnamaldehyde in the Potential Treatment of Fungal Keratitis

Ilhan, Elif; Cesur, Sümeyye; Sulutas, Rabia Betul; Pilavci, Esra; Dalbayrak, Başak; Kaya, Elif; Arısan, Elif Damla; Tinaz, Gulgun Bosgelmez; Şengör, Mustafa; Kijeńska‐Gawrońska, Ewa; Oktar, Faik N.; Gündüz, Oğuzhan

doi:10.1016/j.eurpolymj.2022.111390

Cited by 24 publications

(19 citation statements)

References 41 publications

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“…These acetyl bridges reduce the water solubility of the material. In this study, PVA nanofibers cross‐linked at different times allow controlled release of the drug [58] …”

Section: Resultsmentioning

confidence: 99%

“…In this study, PVA nanofibers cross-linked at different times allow controlled release of the drug. [58] Figure 5. Degradation graphics of non-crosslinked fibers and fibers after crosslinking for, 2 h, 3 h, 4 h, 5 h, 5.5 h, 6 h. The measurement was repeated 3 times for each group.…”

Section: In Vitro Drug Release Profilesmentioning

confidence: 99%

“…[4,5] Polyvinyl alcohol (PVA) has remarkable properties such as high surface stabilization, chelation properties and low protein adsorption resulting in poor cell adhesion compared to other hydrogels for use as a drug delivery system. [6,7] Besides, it shares structural similarities with tissues like skin, cartilage, the cornea, and others.…”

Section: Introductionmentioning

confidence: 99%

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Controlled Release of Gentamicin from Electrospun Poly(Vinyl Alcohol)/Gelatin Nanofibers: The Effect of Crosslinking Time Using Glutaraldehyde Vapor

et al. 2023

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In this study, polyvinyl alcohol (PVA), gelatin (GEL) and gentamicin (GEN) were used and 13PVA/0.5GEL/GEN nanofibers were fabricated with the electrospinning method. These nanofibers were crosslinked chemically with glutaraldehyde (GA) at different time intervals (2, 3, 4, 5, 5.5 and 6 h) to observe the crosslinking effect on the properties of the nanofibers. Morphological analysis reported that as the crosslinking time increased, the nanofiber diameters also increased from 369.26 nm (non‐crosslinked) to 447.72 nm (6 h/crosslinking), respectively. The thermal characterization results demonstrated that crosslinking with different times noticeably shifted the thermal points.The tensile testing results proved that application of crosslinking enhanced the mechanical strength of the nanofibers from 3.31 MPa (non‐crosslinked) to 5.8 MPa (5.5 h/crosslinking), respectively. The GEN release profiles from the nanofibers showed similar behaviors under crosslinking and indicated that the crosslinking time did not have a significant effect on the amount of the GEN released.

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“…These acetyl bridges reduce the water solubility of the material. In this study, PVA nanofibers cross‐linked at different times allow controlled release of the drug [58] …”

Section: Resultsmentioning

confidence: 99%

Section: In Vitro Drug Release Profilesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Controlled Release of Gentamicin from Electrospun Poly(Vinyl Alcohol)/Gelatin Nanofibers: The Effect of Crosslinking Time Using Glutaraldehyde Vapor

et al. 2023

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“…All of the produced electrospun nanofibers were crosslinked by exposition to glutaraldehyde vapors. The nanofibers were positioned on top of the glutaraldehyde solution and incubated in an oven at 60° for 3 h [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

Manufacturing of Zinc Oxide Nanoparticle (ZnO NP)-Loaded Polyvinyl Alcohol (PVA) Nanostructured Mats Using Ginger Extract for Tissue Engineering Applications

et al. 2022

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In this research, as an alternative to chemical and physical methods, environmentally and cost-effective antimicrobial zinc oxide nanoparticles (ZnO NP) were produced by the green synthesis method. The current study focuses on the production of ZnO NP starting from adequate precursor and Zingiber officinale aqueous root extracts (ginger). The produced ZnO NP was loaded into electrospun nanofibers at different concentrations for various tissue engineering applications such as wound dressings. The produced ZnO NPs and ZnO NP-loaded nanofibers were examined by Scanning Electron Microscopy (SEM) for morphological assessments and Fourier-transform infrared spectrum (FT-IR) for chemical assessments. The disc diffusion method was used to test the antimicrobial activity of ZnO NP and ZnO NP-loaded nanofibers against three representatives strains, Escherichia coli (Gram-negative bacteria), Staphylococcus aureus (Gram-positive bacteria), and Candida albicans (fungi) microorganisms. The strength and stretching of the produced fibers were assessed using tensile tests. Since water absorption and weight loss behaviors are very important in tissue engineering applications, swelling and degradation analyses were applied to the produced nanofibers. Finally, the MTT test was applied to analyze biocompatibility. According to the findings, ZnO NP-loaded nanofibers were successfully synthesized using a green precipitation approach and can be employed in tissue engineering applications such as wound dressing.

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“…Additionally, nanofibers consist of an extensive interconnected fiber network and the pores allow incorporation of multiple drug molecules and thereby eliminate drug resistance problems and multiple drug applications. Fluconazole and Cinnamaldehyde loaded two-layer polyvinyl alcohol and gelatin electrospun nanofibers exhibit antifungal and antibiofilm activities simultaneously inhibiting biofilm formation of Candida albicans up to 49% [ 35 ].…”

Section: Topical Nano-formulations For Ocular Drug Deliverymentioning

confidence: 99%

Application of Convergent Science and Technology toward Ocular Disease Treatment

et al. 2023

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Eyes are one of the main critical organs of the body that provide our brain with the most information about the surrounding environment. Disturbance in the activity of this informational organ, resulting from different ocular diseases, could affect the quality of life, so finding appropriate methods for treating ocular disease has attracted lots of attention. This is especially due to the ineffectiveness of the conventional therapeutic method to deliver drugs into the interior parts of the eye, and the also presence of barriers such as tear film, blood-ocular, and blood-retina barriers. Recently, some novel techniques, such as different types of contact lenses, micro and nanoneedles and in situ gels, have been introduced which can overcome the previously mentioned barriers. These novel techniques could enhance the bioavailability of therapeutic components inside the eyes, deliver them to the posterior side of the eyes, release them in a controlled manner, and reduce the side effects of previous methods (such as eye drops). Accordingly, this review paper aims to summarize some of the evidence on the effectiveness of these new techniques for treating ocular disease, their preclinical and clinical progression, current limitations, and future perspectives.

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The Role of Multilayer Electrospun Poly(Vinyl Alcohol)/Gelatin nanofibers loaded with Fluconazole and Cinnamaldehyde in the Potential Treatment of Fungal Keratitis

Cited by 24 publications

References 41 publications

Controlled Release of Gentamicin from Electrospun Poly(Vinyl Alcohol)/Gelatin Nanofibers: The Effect of Crosslinking Time Using Glutaraldehyde Vapor

Controlled Release of Gentamicin from Electrospun Poly(Vinyl Alcohol)/Gelatin Nanofibers: The Effect of Crosslinking Time Using Glutaraldehyde Vapor

Manufacturing of Zinc Oxide Nanoparticle (ZnO NP)-Loaded Polyvinyl Alcohol (PVA) Nanostructured Mats Using Ginger Extract for Tissue Engineering Applications

Application of Convergent Science and Technology toward Ocular Disease Treatment

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