The role of microRNAs in solving COVID-19 puzzle from infection to therapeutics: A mini-review

Paul, Sujay; Bravo-Vázquez, Luis Alberto; Reyes-Pérez, Paula; Estrada-Meza, Carolina; Alburquerque, Rafael Arturo Aponte; Pathak, Surajit; Banerjee, Antara; Bandyopadhyay, Anindya; Chakraborty, Samik; Srivastava, Aashish

doi:10.1016/j.virusres.2021.198631

Cited by 51 publications

(50 citation statements)

References 129 publications

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“…Many clinical renal disorders, such as diabetic nephropathy and chronic kidney disease, may be caused by changes in miRNA expression ( Fan et al, 2020 ). Additionally, miRNA may be used as a diagnostic and monitoring indicator for renal illnesses such as DN and CKD ( Paul et al, 2022 ). miRNA can inhibit viral DNA implication to strengthen the immune system and reduce the risk of SARS-CoV-2 infection ( Srivastava et al, 2021 ).…”

Section: Potential Molecular Signaling Pathways Activated By Sars- Co...mentioning

confidence: 99%

Molecular signaling pathways, pathophysiological features in various organs, and treatment strategies in SARS-CoV2 infection

Rasmi¹,

Hatamkhani²,

Naderi³

et al. 2022

Acta Histochemica

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Section: Potential Molecular Signaling Pathways Activated By Sars- Co...mentioning

confidence: 99%

Molecular signaling pathways, pathophysiological features in various organs, and treatment strategies in SARS-CoV2 infection

Rasmi¹,

Hatamkhani²,

Naderi³

et al. 2022

Acta Histochemica

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“…In the host miRNA pro ling of 67 SARS-CoV-2 patients from 24 countries worldwide, Khan et al discovered that induced mi RNA either neutralises the viral expression or acts as a proviral factor. The study has stated miRNA can be a potential therapeutical option against the COVID 19 complications [130]. The viral miRNAs are inhibitory to the anti-viral proteins produced by the host, increasing the chances of SARS-CoV-2 infection by altering Janus kinase (JAK) 1 and 2 as well as signal transducer and activator of transcription (STAT) 3, 4, 5B, and 6 cellular genes and by suppression of the cytokine signalling (SOCS) cellular genes.…”

Section: Role Of Mirnas In Sars-cov-2 Prognosismentioning

confidence: 99%

Epigenetic perspectives associated with COVID-19 infection and related cytokine storm: An updated review

Dey

Vaishak

Deka

et al. 2022

Preprint

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The COVID-19 pandemic caused by the novel Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-COV-2) has put the world in a medical crisis for the past three years, and almost every country, regardless of its developmental status, has been affected by the situation. Nearly 6.3 million lives have been diminished due to the virus outbreak. Numerous in-depth studies of the mechanisms used by SARS-COV-2 have been going on to minimize the consequences of the viral outburst. Angiotensin-Converting Enzyme 2 receptors and Transmembrane serine protease 2 facilitates the viral entry to the host cells, and upon internalization, it uses the host machinery to replicate viral copies and alter the downstream regulation of the normal cells, causing infection-related morbidities and mortalities. In addition, several epigenetic regulations such as DNA methylation, acetylation, histone modifications, microRNA, and many epigenetic factors such as age and sex are responsible for several upstreaming. Down streaming regulations of the viral entry, its immune evasion, and cytokine responses also play a major modulatory role in COVID-19 severity, which has been discussed in detail in this review.

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“…Notably, a recent study provided novel evidence of an interplay between host miRNAs and SARS-CoV-2, as well as the mechanisms through which these interactions can drive pathogenesis by dysregulating certain immune pathways ( 68 ). A recent mini-review, provided an excellent overview of the role of COVID-19-associated miRNAs as potential therapeutic targets and biomarkers ( 69 ). Currently, there are a number of clinical trials/studies investigating miRNAs in the context of COVID-19.…”

Section: Identification Of Mirnas That Can Target and Regulate The Gene Expression Of Sars-cov-2 Cell Entry Mediatorsmentioning

confidence: 99%

Host cell entry mediators implicated in the cellular tropism of SARS‑CoV‑2, the pathophysiology of COVID‑19 and the identification of microRNAs that can modulate the expression of these mediators (Review)

et al. 2021

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The pathophysiology of coronavirus disease 2019 (COVID-19) is mainly dependent on the underlying mechanisms that mediate the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cells of the various human tissues/organs. Recent studies have indicated a higher order of complexity of the mechanisms of infectivity, given that there is a wide-repertoire of possible cell entry mediators that appear to co-localise in a cell- and tissue-specific manner. The present study provides an over-view of the 'canonical' SARS-CoV-2 mediators, namely angiotensin converting enzyme 2, transmembrane protease serine 2 and 4, and neuropilin-1, expanding on the involvement of novel candidates, including glucose-regulated protein 78, basigin, kidney injury molecule-1, metabotropic glutamate receptor subtype 2, ADAM metallopeptidase domain 17 (also termed tumour necrosis factor-α convertase) and Toll-like receptor 4. Furthermore, emerging data indicate that changes in microRNA (miRNA/miR) expression levels in patients with COVID-19 are suggestive of further complexity in the regulation of these viral mediators. An in silico analysis revealed 160 candidate miRNAs with potential strong binding capacity in the aforementioned genes. Future studies should concentrate on elucidating the association between the cellular tropism of the SARS-CoV-2 cell entry mediators and the mechanisms through which they might affect the clinical outcome. Finally, the clinical utility as a biomarker or therapeutic target of miRNAs in the context of COVID-19 warrants further investigation.

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The role of microRNAs in solving COVID-19 puzzle from infection to therapeutics: A mini-review

Cited by 51 publications

References 129 publications

Molecular signaling pathways, pathophysiological features in various organs, and treatment strategies in SARS-CoV2 infection

Molecular signaling pathways, pathophysiological features in various organs, and treatment strategies in SARS-CoV2 infection

Epigenetic perspectives associated with COVID-19 infection and related cytokine storm: An updated review

Host cell entry mediators implicated in the cellular tropism of SARS‑CoV‑2, the pathophysiology of COVID‑19 and the identification of microRNAs that can modulate the expression of these mediators (Review)

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