The role of lactobacilli and probiotics in maintaining vaginal health

Borges, Sandra; Silva, Joana; Teixeira, Paula

doi:10.1007/s00404-013-3064-9

Cited by 288 publications

(245 citation statements)

References 53 publications

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“…Whereas Lactobacillus casei utilizes EMB pathways as well as 6-phosphogluconate/ phosphoketolase pathways and produces CO 2 and ethanol along with lactic acid. 21 Changes in pH by Lactobacilli strains containing Fructoligosaccharide (FOS) and Galactooligosaccharide (GOS): Figure 1 indicate distinct pH lowering effect of FOS and GOS compared to control (without prebiotics). It proved the stimulating effect of FOS and GOS on Lactobacilli.…”

Section: Effect Of Oligosaccharides On the Growth Of Selectedmentioning

confidence: 99%

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Investigation of Oligosaccharides for Prebitoic Action on Vaginal Lactobacilli

Mahore¹,

Rohit²,

Deshkar³

2017

JYP

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Objective: Vaginitis is a very common gynaecological problem in women of all age groups resulted in millions of visit to physician. Decrease in vaginal Lactobacilli is one of the reasons of Bacterial vaginitis. Approach that could improve decreased level of Lactobacilli and inhibit growth of pathogenic bacteria can be alternative to antibiotic therapy. Oligosaccharides influence the growth of Lactobacilli species and benefits vaginal ecosystem. The present study was designed to evaluate prebitoic potential of oligosaccharides in vaginitis. Methodology: The potential of oligosaccharides to stimulate the growth of three selected vaginal Lactobacilli strains was studied by optical density, pH, titrable acidity and dry mass after 48 h of incubation. The antimicrobial effect of vaginal Lactobacilli in presence of oligosaccharide against pathogenic bacteria E. coli and C. albicans was studied by agar diffusion method. Vaginal irritation test was studied on female Swiss albino mice. Results and Discussion: Increased lactic acid production and lowering of pH by Lactobacilli strains in presence of oligosaccharides confirmed that oligosaccharide can stimulate the growth of selected Lactobacilli species. Optical density and dry biomass was also increased during 48 h of incubation. Higher zone of inhibition was observed in presence of prebiotic compared to control (without prebiotic). Vaginal irritation study showed no significant changes. Conclusively, oligosaccharides supported the growth of selected strains and could restore bacterial environment.

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Section: Effect Of Oligosaccharides On the Growth Of Selectedmentioning

confidence: 99%

“…Bacteriocin (antimicrobial peptides or proteins) are produced by almost all genera of lactic acid bacteria. 26 The FOS and GOS stimulate the growth of Lactobacilli strain and suppress growth of potentially harmful species in the vagina ecosystem.…”

Section: Antimicrobial Activity Of Lactobacillus Acidophilus Containimentioning

confidence: 99%

Investigation of Oligosaccharides for Prebitoic Action on Vaginal Lactobacilli

Mahore¹,

Rohit²,

Deshkar³

2017

JYP

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“…Concomitant treatment with probiotic lactobacilli is therefore considered as adjuvant therapy to restore the beneficial lactobacilli flora in these postmenopausal women 4 . The efficacy of exogenous lactobacilli for the restoration of the vaginal flora in premenopausal women having received anti-infective therapy is well documented 66,71 . Furthermore, evidence of the synergistic effect of combined estriol-lactobacilli treatment in postmenopausal women has been shown in a clinical study investigating the improvement of urogenital aging 59 .…”

Section: Lactobacillimentioning

confidence: 99%

Treatment of vaginal atrophy with estriol and lactobacilli combination: a clinical review

Mueck

Ruan

Prasauskas³

et al. 2018

Climacteric

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In recent years, a vast quantity of clinical data has been accumulated on the pathophysiology of symptomatic vulvovaginal atrophy (VVA)/genitourinary syndrome of menopause (GSM) in peri-and postmenopausal women and on the treatment options for these conditions. Guidelines from several societies have recently been updated in favor of VVA/GSM vaginal therapy with the lowest possible doses of estrogens. The combination of a vaginal ultra-low dose of 0.03 mg of estriol (E3) and lyophilized, viable Lactobacillus acidophilus KS400 (0.03 mg-E3/L) is a unique product with a dual mechanism of action supporting not only the proliferation and maturation of the vaginal epithelium, but also restoration of the lactobacillary microflora. It has been demonstrated efficiently to establish and maintain a healthy vaginal ecosystem. Use of this combination considerably improves the clinical signs and symptoms as well as the quality of life of menopausal women suffering from vaginal atrophy. This combination therapy is well tolerated with a low overall incidence of side-effects and negligible estriol absorption. Based on recent scientific evidence and current treatment guidelines, the 0.03 mg-E3/L combination could be considered one of the options for the treatment of symptomatic vaginal atrophy in aging menopausal women. ARTICLE HISTORY

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“…In the vaginal microbiome, lactobacilli constitute the dominant proportion (80%) of bacteria inhabiting the healthy women's vagina [1,2,[5][6][7]12,13]. Some LAB strains have found to be endogenous from healthy human vagina, where there is a rather stable microbiota [14][15][16].…”

Section: Vaginal Microbiome Ecological and Functional Aspectsmentioning

confidence: 99%

Profiles and technological requirements of urogenital probiotics

Nader‐Macías

Tomás

2015

Advanced Drug Delivery Reviews

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Probiotics, defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host, are considered a valid and novel alternative for the prevention and treatment of female urogenital tract infections. Lactobacilli, the predominant microorganisms of the healthy human vaginal microbiome, can be included as active pharmaceutical ingredients in probiotics products. Several requirements must be considered or criteria fulfilled during the development of a probiotic product or formula for the female urogenital tract. This review deals with the main selection criteria for urogenital probiotic microorganisms: host specificity, potential beneficial properties, functional specifications, technological characteristics and clinical trials used to test their effect on certain physiological and pathological conditions. Further studies are required to complement the current knowledge and support the clinical applications of probiotics in the urogenital tract. This therapy will allow the restoration of the ecological equilibrium of the urogenital tract microbiome as well as the recovery of the sexual and reproductive health of women.Fil: Nader, Maria Elena Fatima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; ArgentinaFil: Juárez Tomás, María Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentin

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The role of lactobacilli and probiotics in maintaining vaginal health

Abstract: The administration of probiotics that colonize the vaginal tract can be important in maintaining a normal urogenital health and also to prevent or treat infections.

Cited by 288 publications

References 53 publications

Investigation of Oligosaccharides for Prebitoic Action on Vaginal Lactobacilli

Investigation of Oligosaccharides for Prebitoic Action on Vaginal Lactobacilli

Treatment of vaginal atrophy with estriol and lactobacilli combination: a clinical review

Profiles and technological requirements of urogenital probiotics

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