The role of ischemic preconditioning in the expression of apoptosis-related genes in a rat model of intestinal ischemia-reperfusion injury

Miranda, Celina Teresa Castelo Branco Couto de; Fagundes, Djalma José; Miranda, Edinaldo de; Simões, Ricardo Santos; Carbonel, Adriana Aparecida Ferraz; Florencio‐Silva, Rinaldo; Taha, Murched Omar

doi:10.1590/s0102-865020190050000001

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…IPC involves short-term ischemia and reperfusion of the intestinal tissue before the expected ischemia period, which can initiate the endogenous protective mechanism to deal with the subsequent ischemia for a prolonged period and reduce the damage to tissues and organs. This is adaptive protective mechanism for a transient ischemic period ( Miranda et al, 2019 ). Many studies have shown that IPC can reduce intestinal tissue damage and alleviate SIRS.…”

Section: Prevention and Treatment Of Intestinal Ischemia/reperfusion ...mentioning

confidence: 99%

Mitochondrial DNA Release Contributes to Intestinal Ischemia/Reperfusion Injury

et al. 2022

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Mitochondria release many damage-associated molecular patterns (DAMPs) when cells are damaged or stressed, with mitochondrial DNA (mtDNA) being. MtDNA activates innate immune responses and induces inflammation through the TLR-9, NLRP3 inflammasome, and cGAS-STING signaling pathways. Released inflammatory factors cause damage to intestinal barrier function. Many bacteria and endotoxins migrate to the circulatory system and lymphatic system, leading to systemic inflammatory response syndrome (SIRS) and even damaging the function of multiple organs throughout the body. This process may ultimately lead to multiple organ dysfunction syndrome (MODS). Recent studies have shown that various factors, such as the release of mtDNA and the massive infiltration of inflammatory factors, can cause intestinal ischemia/reperfusion (I/R) injury. This destroys intestinal barrier function, induces an inflammatory storm, leads to SIRS, increases the vulnerability of organs, and develops into MODS. Mitophagy eliminates dysfunctional mitochondria to maintain cellular homeostasis. This review discusses mtDNA release during the pathogenesis of intestinal I/R and summarizes methods for the prevention or treatment of intestinal I/R. We also discuss the effects of inflammation and increased intestinal barrier permeability on drugs.

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Section: Prevention and Treatment Of Intestinal Ischemia/reperfusion ...mentioning

confidence: 99%

Mitochondrial DNA Release Contributes to Intestinal Ischemia/Reperfusion Injury

et al. 2022

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Mild-intensity Exercise Triggers VEGF in the Digestive Tract Via Both Hypoxic and Nonhypoxic Mechanisms

Hoşgörler

Kızıldağ

Koç

et al. 2020

Braz. arch. biol. technol.

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Hypoxia occurs in the splanchnic region during exercise associated with sympathetic activity. In the elderly, vascular insufficiency and low vascular endothelial growth factor (VEGF) expression are observed. Compared to young people, sympathetic signals of older individuals are blunted and more resistant to splanchnic blood flow alterations during exercise. VEGF induces vasodilation responses and hence may retain blood in the splanchnic vascular bed. We hypothesized that regular mild-intensity exercise triggers weak VEGF expression in the digestive tract of the elderly. The effects of exercise on the levels of VEGF, superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA) and total antioxidant capacity (T-AOC) in the stomach, jejunum, ileum and colon tissues were evaluated. With exercise, the VEGF levels in the stomach and colon increased. Although the SOD, GPx, and MDA levels decreased in the HIGHLIGHTS  Low vascular endothelial growth factor expression is observed in the elderly. Exercise leads to hypoxia in the splanchnic region. Mild intensity exercise induces vascular endothelial growth factor in the elderly. In older subjects, mild intensity exercise increases antioxidant capacity in the stomach.  Hypoxic involvement due to exercise is more pronounced in the large intestine compared to other parts of the digestive tract.   Insert 1-4 highlights no longer than 85 characters.  Insert a highlight no longer than 85 characters. Insert a highlight no longer than 85 characters.• Insert a highlight no longer than 85 characters. Hosgorler, F.; et al.

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The role of ischemic preconditioning in the expression of apoptosis-related genes in a rat model of intestinal ischemia-reperfusion injury

Cited by 2 publications

References 23 publications

Mitochondrial DNA Release Contributes to Intestinal Ischemia/Reperfusion Injury

Mitochondrial DNA Release Contributes to Intestinal Ischemia/Reperfusion Injury

Mild-intensity Exercise Triggers VEGF in the Digestive Tract Via Both Hypoxic and Nonhypoxic Mechanisms

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