Mild-intensity Exercise Triggers VEGF in the Digestive Tract Via Both Hypoxic and Nonhypoxic Mechanisms

Abstract

Hypoxia occurs in the splanchnic region during exercise associated with sympathetic activity. In the elderly, vascular insufficiency and low vascular endothelial growth factor (VEGF) expression are observed. Compared to young people, sympathetic signals of older individuals are blunted and more resistant to splanchnic blood flow alterations during exercise. VEGF induces vasodilation responses and hence may retain blood in the splanchnic vascular bed. We hypothesized that regular mild-intensity exercise triggers weak VEGF expression in the digestive tract of the elderly. The effects of exercise on the levels of VEGF, superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA) and total antioxidant capacity (T-AOC) in the stomach, jejunum, ileum and colon tissues were evaluated. With exercise, the VEGF levels in the stomach and colon increased. Although the SOD, GPx, and MDA levels decreased in the HIGHLIGHTS  Low vascular endothelial growth factor expression is observed in the elderly. Exercise leads to hypoxia in the splanchnic region. Mild intensity exercise induces vascular endothelial growth factor in the elderly. In older subjects, mild intensity exercise increases antioxidant capacity in the stomach.  Hypoxic involvement due to exercise is more pronounced in the large intestine compared to other parts of the digestive tract.   Insert 1-4 highlights no longer than 85 characters.  Insert a highlight no longer than 85 characters. Insert a highlight no longer than 85 characters.• Insert a highlight no longer than 85 characters. Hosgorler, F.; et al.

Broiler İleumunda Kuluçka Sonrası Farklı Dönemlerin TLR4 ve VEGF Ekspresyon Paternleri Üzerine Etkisi

“…Also, hypoxia-inducible factor-1 alpha (HIF-1α) and reactive oxygen species (ROS) have been shown to activate VEGF. HIF-1α regulates VEGF gene expression and provides the adaptive responses required for gastrointestinal homeostasis maintenance under hypoxia (28). It has been observed that the source of VEGF in the ileocecal region is especially the crypt regions of the surface epithelium.…”

Molecular mechanisms of glial cells in brain disorders following physical exercise

“…Vascular endothelial growth factor (VEGF) is a signaling protein that promotes the growth of new blood vessels. In older adults, gentle exercise may trigger weak VEGF expression through both hypoxic and nonhypoxic mechanisms [82]. Another neurotrophic factor involved in exercise-facilitated neuroprotection is IGF-1.…”

The Zebrafish (Danio rerio) as a Model for Studying Voluntary Physical Exercise and its Effects on Behavior and Metabolism

“…Any type of exercise is beneficial to health [7][8][9][10][11][12][13], but given the need to evaluate physical performance and the effects of exercise on diseases, it was necessary to develop models of aerobic [14,15] and sprint exercise training [16]. A voluntary physical exercise (VPE) model for zebrafish has not yet been described, although such model is already widespread in rodents [17][18][19][20][21].…”