The Role of Intranasal Oxytocin in Anxiety and Depressive Disorders: A Systematic Review of Randomized Controlled Trials

Cagna, F. De; Fusar-Poli, Laura; Damiani, Stefano; Rocchetti, Matteo; Giovanna, Gianluca; Mori, Alessia; Politi, Pierluigi; Brondino, Natascia

doi:10.9758/cpn.2019.17.1.1

Cited by 91 publications

(44 citation statements)

References 73 publications

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“… “A systematic literature search was performed in Web of Knowledge™ (including KCI Korean Journal Database, MEDLINE, Russian Science Citation Index, and SciELO Citation Index)….” [ 52 ] …”

Section: Part 3: Explanation and Elaborationmentioning

confidence: 99%

PRISMA-S: an extension to the PRISMA Statement for Reporting Literature Searches in Systematic Reviews

et al. 2021

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Background Literature searches underlie the foundations of systematic reviews and related review types. Yet, the literature searching component of systematic reviews and related review types is often poorly reported. Guidance for literature search reporting has been diverse, and, in many cases, does not offer enough detail to authors who need more specific information about reporting search methods and information sources in a clear, reproducible way. This document presents the PRISMA-S (Preferred Reporting Items for Systematic reviews and Meta-Analyses literature search extension) checklist, and explanation and elaboration. Methods The checklist was developed using a 3-stage Delphi survey process, followed by a consensus conference and public review process. Results The final checklist includes 16 reporting items, each of which is detailed with exemplar reporting and rationale. Conclusions The intent of PRISMA-S is to complement the PRISMA Statement and its extensions by providing a checklist that could be used by interdisciplinary authors, editors, and peer reviewers to verify that each component of a search is completely reported and therefore reproducible.

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Section: Part 3: Explanation and Elaborationmentioning

confidence: 99%

PRISMA-S: an extension to the PRISMA Statement for Reporting Literature Searches in Systematic Reviews

et al. 2021

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“…OXT exerts anxiolytic and antidepressant effects and modulates neuronal functions associated with stress responses 70 . For example, intranasal OXT treatment was shown to decrease HPA axis activity, anxiety- and depression-related symptoms 71 – 73 . Since there is a significant comorbidity between these disorders 74 , 75 , common mediators such as OXT are presumably to underlie both psychiatric disorders 70 .…”

Section: Discussionmentioning

confidence: 99%

The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice

Bashiri

Houwing

Homberg

et al. 2021

Sci Rep

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Gestational stress can increase postpartum depression in women. To treat maternal depression, fluoxetine (FLX) is most commonly prescribed. While FLX may be effective for the mother, at high doses it may have adverse effects on the fetus. As environmental enrichment (EE) can reduce maternal stress effects, we hypothesized that a subthreshold dose of FLX increases the impact of EE to reduce anxiety and depression-like behavior in postpartum dams exposed to gestational stress. We evaluated this hypothesis in mice and to assess underlying mechanisms we additionally measured hypothalamic–pituitary–adrenal (HPA) axis function and brain levels of the hormone oxytocin, which are thought to be implicated in postpartum depression. Gestational stress increased anxiety- and depression-like behavior in postpartum dams. This was accompanied by an increase in HPA axis function and a decrease in whole-brain oxytocin levels in dams. A combination of FLX and EE remediated the behavioral, HPA axis and oxytocin changes induced by gestational stress. Central administration of an oxytocin receptor antagonist prevented the remediating effect of FLX + EE, indicating that brain oxytocin contributes to the effect of FLX + EE. These findings suggest that oxytocin is causally involved in FLX + EE mediated remediation of postpartum stress-related behaviors, and HPA axis function in postpartum dams.

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“…Although there are studies showing that oxytocin spray may decrease anxiety in humans, the recent systematic review of the randomized controlled trials (RCTs) demonstrated that the effect of OT spray on anxiety and depressive symptoms is still inconclusive (De Cagna et al, 2019 ).…”

Section: Importance Of Hypothalamic Oxytocin In Stressmentioning

confidence: 99%

Sensory Stimulation of Oxytocin Release Is Associated With Stress Management and Maternal Care

Takahashi

2021

Front. Psychol.

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It has been shown that various types of stress initiate different physiological and neuroendocrine disorders. Oxytocin (OT) is mainly produced in the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus. Hypothalamic OT has antistress effects and attenuates the hypothalamic–pituitary–adrenal (HPA) axis. One mechanism behind the antistress effects of OT is mediated through the inhibition from GABAA receptors on corticotropin-releasing factor (CRF) expression at the PVN. Various manual therapies such as acupuncture, transcutaneous electrical nerve stimulation (TENS), and massage initiate the stimulation of somatosensory neurons of the body. It is well-known that TENS simulates OT expression, while it inhibits CRF expression at the PVN following chronic stress loading in rodents. Upregulation of OT expression at the hypothalamus is activated by the somatosensory stimulation, which is mediated via the spinothalamic pathway (the connection between the spinal cord and hypothalamus). Thus, somatosensory stimulation is beneficial in treating stress-associated symptoms. Hypothalamic OT is associated with the social behaviors, including maternal care and affiliation. Childhood neglect and/or child abuse are severely responsible for deleterious long-term effects on the cognitive/social activity and behavioral development. At parturition, a profound amount of OT is released into the systemic circulation in response to vaginal and cervical stimulation caused by the body of fetus, which induces the onset of maternal behavior. Peridural anesthesia effectively impairs the sensitivity to vaginal and cervical stimulation at parturition. OT levels in cerebrospinal fluid is significantly reduced following peridural anesthesia. The vaginal delivery mothers had significantly more OT pulses than the caesarian section (CS) mothers. Due to low levels of endogenous OT, maternal behavior could be interrupted by epidural anesthesia and CS at parturition because of the reduction of the usual sensory input from the genitalia.

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The Role of Intranasal Oxytocin in Anxiety and Depressive Disorders: A Systematic Review of Randomized Controlled Trials

Cited by 91 publications

References 73 publications

PRISMA-S: an extension to the PRISMA Statement for Reporting Literature Searches in Systematic Reviews

PRISMA-S: an extension to the PRISMA Statement for Reporting Literature Searches in Systematic Reviews

The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice

Sensory Stimulation of Oxytocin Release Is Associated With Stress Management and Maternal Care

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