The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice

Bashiri, Hamideh; Houwing, Danielle J.; Homberg, Judith R.; Salari, Ali-Akbar

doi:10.1038/s41598-021-87800-z

Cited by 24 publications

(6 citation statements)

References 90 publications

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“…As Both ketamine and uoxetine ameliorated anxiety-related behaviours, aligning with known anxiolytic effects (Houwing et al 2019;Carrier and Kabbaj 2013). The mechanism may involve buffering excess stimulation of the HPA axis and downstream corticosterone release triggered by maternal stress (Bashiri et al 2021). A rat model of in ammation-induced prenatal stress found that uoxetine prevented epigenetic effects on corticotrophin releasing factor receptor 2, which could mitigate anxiety by potentiating serotonin signalling (Bashiri et al 2021).…”

Section: Discussionmentioning

confidence: 84%

“…Cortisol crosses the placenta, directly impacting the offspring's developing HPA axis, predisposing them to affective disorders and cognitive de cits (Czarzasta et al 2019). Fluoxetine treatment during pregnancy prevents some HPA axis alterations by reducing corticosterone and ACTH levels while increasing oxytocin and vasopressin expression (Bashiri et al 2021).…”

Section: Introductionmentioning

confidence: 99%

“…This sets in motion in ammatory cascades altering neurotransmitters, neurotrophic factors, hormones, and neural connectivity (Dean et al 2018). Fluoxetine may mitigate in ammation-induced epigenetic changes, as it increased histone acetylation of brain-derived neurotrophic factor (BDNF) and corticotrophin releasing factor receptor 2 while decreasing methylation of these key genes related to stress resilience (Bashiri et al 2021).…”

Section: Introductionmentioning

confidence: 99%

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Ketamine role in the treatment of Maternal depression: effects on offspring behaviour

Thanoon,

Althanoon

2024

Preprint

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Maternal depression during pregnancy adversely affects offspring neurodevelopment and behaviour. Typical antidepressants like selective serotonin reuptake inhibitors have limitations due to risks of crossing the placenta. Ketamine has emerged as a promising alternative treatment. This research examined ketamine's effects on offspring of maternally stressed mice. Dams were divided into control, maternal adversity, fluoxetine, and ketamine groups. Open field, sucrose preference, elevated plus maze, and forced swim tests assessed offspring anxiety, anhedonia, and despair. Maternal adversity increased anxiety-like behaviours and ketamine or fluoxetine reversed some effects. However, fluoxetine more effectively mitigated despair in forced swim tests. Ketamine moderately alleviated anhedonia versus controls. Further research on dose-response and timing is needed to optimize ketamine treatment. Mitigating maternal depression is crucial for preventing maladaptive offspring neurobehavioral trajectories.

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ketamine role in the treatment of Maternal depression: effects on offspring behaviour

Thanoon,

Althanoon

2024

Preprint

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“…In the results of this study, the AUC was 0.89, close to 0.9, so we think that saliva cortisol testing can be considered an auxiliary method for the clinical diagnosis of depression, and its diagnostic value is moderate. In addition, the collection of saliva cortisol in this study allows for non-invasive collection at regular intervals, which can be stably collected for several days before the experiment, so that the HPA axis in the free state can be effectively evaluated [ 68 , 69 ]. The assessment of cortisol in saliva has proven effective and reliable in reflecting the respective unbound hormones in the blood [ 70 , 71 ].…”

Section: Discussionmentioning

confidence: 99%

Stimulated Parotid Saliva Is a Better Method for Depression Prediction

et al. 2022

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Background: Saliva cortisol is considered to be a biomarker of depression prediction. However, saliva collection methods can affect the saliva cortisol level. Objective: This study aims to determine the ideal saliva collection method and explore the application value of saliva cortisol in depression prediction. Methods: 30 depressed patients and 30 healthy controls were instructed to collect saliva samples in the morning with six collection methods. Simultaneous venous blood was collected. Enzyme-linked immunosorbent assay was used to determine the cortisol level. The 24-observerrated Hamilton depression rating scale (HAMD-24) was used to assess the severity of depression. Results: The significant differences in saliva cortisol levels depend on the saliva collection methods. The level of unstimulated whole saliva cortisol was most correlated with blood (r = 0.91). The stimulated parotid saliva cortisol can better predict depression. The area under the curve was 0.89. In addition, the saliva cortisol level of the depression patients was significantly higher than the healthy controls. The correlation between the cortisol level and the HAMD-24 score was highly significant. The higher the saliva cortisol level, the higher the HAMD-24 score. Conclusions: All the above findings point to an exciting opportunity for non-invasive monitoring of cortisol through saliva.

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“…between two animals was recorded as an index of social behaviour as previously described (Bashiri et al, 2021).…”

Section: Social Interaction Testmentioning

confidence: 99%

Swimming exercise decreases depression‐like behaviour and inflammatory cytokines in a mouse model of type 2 diabetes

Gilak-Dalasm

Peeri

Azarbayjani

2021

Experimental Physiology

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Clinical and experimental studies have shown that type 2 diabetes is associated with depression-related disorders. Inflammation has been identified as a common mechanism in both type 2 diabetes and depression. Several studies have suggested that swimming exercise might be able to reduce depression-related symptoms. The present study aimed to explore whether swimming exercise can decrease depressionlike behaviour in type 2 diabetic mice. To induce type 2 diabetes, male C57BL6 mice were treated with a high-fat diet and streptozocin. Type 2 diabetic animals were subjected to swimming exercise for 4 weeks. Then, depression-like behaviours were evaluated by sucrose preference, novelty-suppressed feeding, social interaction and tail suspension tests. We also measured levels of glucose, insulin and pro-inflammatory cytokines such as interleukin-1β and tumour necrosis factor-α in the serum of animals.The results indicated that type 2 diabetes significantly increased anhedonia-and depression-like behaviours in mice. We also found significant increases in glucose, insulin and inflammatory cytokines in diabetic mice. Moreover, swimming exercise reduced anhedonia-and depression-like behaviour in type 2 diabetic mice. Swimming exercise also decreased glucose and inflammatory cytokines in the serum of mice with type 2 diabetes. Collectively, this study demonstrates that swimming exercise decreased depression-like behaviour by reducing inflammation in type 2 diabetic mice.Further clinical studies are needed to validate these findings in patients with type 2 diabetes.

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The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice

Cited by 24 publications

References 90 publications

Ketamine role in the treatment of Maternal depression: effects on offspring behaviour

Ketamine role in the treatment of Maternal depression: effects on offspring behaviour

Stimulated Parotid Saliva Is a Better Method for Depression Prediction

Swimming exercise decreases depression‐like behaviour and inflammatory cytokines in a mouse model of type 2 diabetes

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