The role of <i>Fusobacterium nucleatum</i> in colorectal cancer: from carcinogenesis to clinical management

Sun, Chunhui; Li, Binbin; Wang, Bo; Zhao, Jing; Zhang, Xiaoying; Li, Tingting; Li, Wenbing; Tang, Di; Qiu, Miaojuan; Wang, Xincheng; Zhu, Chengming; Qian, Zhenyun

doi:10.1016/j.cdtm.2019.09.001

Cited by 88 publications

(92 citation statements)

References 79 publications

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“…The main functions performed by gut microbiota are trophic (i.e., the control of epithelial cell proliferation and differentiation), metabolic (i.e., the fermentation of indigestible food components into absorbable metabolites), and protective (i.e., the out-competition of pathogens) that are essential to maintain human health status. As the gut microbiota has a well-established role in host homeostasis, several highly prevalent gastrointestinal diseases, including cancer, have been associated with dysbiosis in microbiota composition [33].…”

Section: Oral and Intestinal Microbiota And Colorectal Cancermentioning

confidence: 99%

Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer

et al. 2020

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Colorectal cancer (CRC) is the third most diagnosed type of cancer worldwide. Dietary features play an important role in its development, and the involvement of human microbial communities in this pathology has also recently been recognized. Individuals with CRC display alterations in gut bacterial composition and a notably higher abundance of putative oral bacteria in colonic tumors. Many experimental studies and preclinical evidence propose that dietary polyphenols have a relevant role in CRC development and progression, mainly attributed to their immunomodulatory activities. Furthermore, polyphenols can modulate oral and gut microbiota, and in turn, intestinal microbes catabolize polyphenols to release metabolites that are often more active and better absorbed than the original phenolic compounds. The current study aimed to review and summarize current knowledge on the role of microbiota and the interactions between dietary polyphenols and microbiota in relation to CRC development. We have highlighted the mechanisms by which dietary polyphenols and/or their microbial metabolites exert their action on the pathogenesis and prevention of CRC as modulators of the composition and/or activity of oral and intestinal microbiota, including novel screening biomarkers and possible nutritional therapeutic implications.

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Section: Oral and Intestinal Microbiota And Colorectal Cancermentioning

confidence: 99%

Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer

et al. 2020

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“…There is also cumulative evidence that suggests a link between gut, colorectal adenoma, CRC, and some specific species such as Fusobacterium nucleatum [ 144 , 145 ].…”

Section: Gut Microbiota and Their Metabolites In Adenomatous Colonmentioning

confidence: 99%

An Overview of Gut Microbiota and Colon Diseases with a Focus on Adenomatous Colon Polyps

Pop

Vodnar

Diaconeasa

et al. 2020

IJMS

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It is known and accepted that the gut microbiota composition of an organism has an impact on its health. Many studies deal with this topic, the majority discussing gastrointestinal health. Adenomatous colon polyps have a high prevalence as colon cancer precursors, but in many cases, they are hard to diagnose in their early stages. Gut microbiota composition correlated with the presence of adenomatous colon polyps may be a noninvasive and efficient tool for diagnosis with a high impact on human wellbeing and favorable health care costs. This review is meant to analyze the gut microbiota correlated with the presence of adenomatous colon polyps as the first step for early diagnosis, prophylaxis, and treatment.

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“…For example, it has been reported that the enterotoxigenic Bacteroides fragilis contribute to colon carcinogenesis by producing toxins [ 11 ]. Together with numerous potential carcinogenic intestinal microorganisms, Fusobacterium nucleatum ( F. nucleatum ) has been reported to be a contributing factor to CRC progression based on its presence in CRC specimens [ 12 , 13 , 14 ]. The importance of F. nucleatum in CRC is further supported by reports that it increases the chemoresistance of colon cancer via modulating autophagy and enhances the proliferation and tumor development of CRC by activating Toll-like receptor 4 (TLR4) signaling [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Fusobacterium nucleatum Accelerates the Progression of Colitis-Associated Colorectal Cancer by Promoting EMT

Kim

Park

2020

Cancers

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Recently, it has been reported that Fusobacterium nucleatum, a major pathogen involved in chronic periodontitis, may play an important role in colorectal cancer (CRC) progression. In addition, inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease represent major predisposing conditions for the development of CRC, and this subtype of cancer is called colitis-associated cancer (CAC). Although the importance of F. nucleatum in CRC has attracted attention, its exact role and related mechanism in CAC progression remain unclear. In this study, we investigated the effects of F. nucleatum in experimental colitis induced with dextran sodium sulfate (DSS), which is a well-known colitis-inducing chemical, on the aggressiveness of CAC and its related mechanism in both in vitro and in vivo models. F. nucleatum synergistically increased the aggressiveness and epithelial–mesenchymal transition (EMT) characteristics of CRC cells that were treated with DSS compared to those in non-treated CRC cells. The role of F. nucleatum in CAC progression was further confirmed in mouse models, as F. nucleatum was found to significantly increase the malignancy of azoxymethane (AOM)/DSS-induced colon cancer. This promoting effect of F. nucleatum was based on activation of the EGFR signaling pathways, including protein kinase B (AKT) and extracellular signal-regulated kinase (ERK), and epidermal growth factor receptor (EGFR) inhibition significantly reduced the F. nucleatum-induced EMT alteration. In conclusion, F. nucleatum accelerates the progression of CAC by promoting EMT through the EGFR signaling pathway.

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The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management

Cited by 88 publications

References 79 publications

Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer

Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer

An Overview of Gut Microbiota and Colon Diseases with a Focus on Adenomatous Colon Polyps

Fusobacterium nucleatum Accelerates the Progression of Colitis-Associated Colorectal Cancer by Promoting EMT

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