The role of FSH and TGF-β superfamily in follicle atresia

Chu, Yulan; Xu, Yaru; Yang, Wan-Xi; Sun, Yi

doi:10.18632/aging.101391

Cited by 65 publications

(38 citation statements)

References 135 publications

(175 reference statements)

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“…In this study, we found that miR-1185-3p targeted CLDN10 and CADM1 and mediated the cell adhesion molecules to regulate ovarian function. Further, the TGF-β signaling pathway is widely involved in functions such as cell proliferation, apoptosis, differentiation, and migration, which affect follicular development, embryonic development, and organ formation [ 80 , 81 ]. BMP7 [ 82 ], BMP5 [ 83 ], FMOD [ 84 ], TGFB2 [ 85 ], BMPR1B [ 86 ], and SMAD7 [ 87 ] are the main genes in this pathway, and they are closely related to granulosa cell development, follicular maturation, and ovulation.…”

Section: Discussionmentioning

confidence: 99%

A Preliminary Study on the Characteristics of microRNAs in Ovarian Stroma and Follicles of Chuanzhong Black Goat during Estrus

Zou

Liu

et al. 2020

Genes

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microRNAs (miRNAs) play a significant role in ovarian follicular maturity, but miRNA expression patterns in ovarian stroma (OS), large follicles (LF), and small follicles (SF) have been rarely explored. We herein aimed to identify miRNAs, their target genes and signaling pathways, as well as their interaction networks in OS, LF, and SF of Chuanzhong black goats at the estrus phase using small RNA-sequencing. We found that the miRNA expression profiles of LF and SF were more similar than those of OS—32, 16, and 29 differentially expressed miRNAs were identified in OS vs. LF, OS vs. SF, and LF vs. SF, respectively. Analyses of functional enrichment and the miRNA-targeted gene interaction network suggested that miR-182 (SMC3), miR-122 (SGO1), and miR-206 (AURKA) were involved in ovarian organogenesis and hormone secretion by oocyte meiosis. Furthermore, miR-202-5p (EREG) and miR-485-3p (FLT3) were involved in follicular maturation through the MAPK signaling pathway, and miR-2404 (BMP7 and CDKN1C) played a key role in follicular development through the TGF-β signaling pathway and cell cycle; nevertheless, further research is warranted. To our knowledge, this is the first study to investigate miRNA expression patterns in OS, LF, and SF of Chuanzhong black goats during estrus. Our findings provide a theoretical basis to elucidate the role of miRNAs in follicular maturation. These key miRNAs might provide candidate biomarkers for the diagnosis of follicular maturation and will assist in developing new therapeutic targets for female goat infertility.

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Section: Discussionmentioning

confidence: 99%

A Preliminary Study on the Characteristics of microRNAs in Ovarian Stroma and Follicles of Chuanzhong Black Goat during Estrus

Zou

Liu

et al. 2020

Genes

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“…Studies have shown that activated PI3K/AKT pathway is closely related to the occurrence of chondrocyte apoptosis in OA. FSH is associated with the occurrence of various diseases by activating the PI3K/AKT signaling pathway [19][20][21]. For example, elevated FSH activates the PI3K/AKT signaling pathway and promotes the proliferation of ovarian cancer cells [22].…”

Section: Discussionmentioning

confidence: 99%

High follicle‐stimulating hormone levels accelerate cartilage damage of knee osteoarthritis in postmenopausal women through the PI3K/AKT/NF‐κB pathway

et al. 2020

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Knee osteoarthritis (KOA) is prevalent in postmenopausal women and a cause of pain and disability in elderly populations. Here, we report high follicle‐stimulating hormone (FSH) levels across postmenopausal female KOA patients aged 50–60 years. We speculate FSH might damage cartilage tissues through the phosphoinositide 3‐kinase/AKT/nuclear factor kappa B pathway. Our findings suggest that FSH modulation holds promise as a novel treatment for postmenopausal female KOA patients aged 50–60 years.

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“…GnRH is a key regulator in the hypothalamic-pituitary-gonadal axis. The GnRH pathway alters follicle growth, secretion and ovulation [ 29 , 61 ]. The ovaries also undergo various biological processes during the oestrous cycle.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide differences in DNA methylation changes in caprine ovaries between oestrous and dioestrous phases

Ping

et al. 2018

J Animal Sci Biotechnol

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BackgroundDNA methylation plays a vital role in reproduction. Entire genome DNA methylation changes during the oestrous phase (ES) and dioestrous phase (DS) in the ovaries of Guanzhong dairy goats were investigated using bisulphite sequencing to understand the molecular biological mechanisms of these goats’ oestrous cycle.ResultsWe discovered distinct genome-wide DNA methylation patterns in ES and DS ovaries. A total of 26,910 differentially methylated regions were upregulated and 21,453 differentially methylated regions were downregulated in the ES samples compared with the DS samples (P-values ≤0.05 and fold change of methylation ratios ≥2). Differentially methylated region analysis showed hypomethylation in the gene body regions and hypermethylation in the joining region between upstream regions and gene bodies. The methylation ratios of the STAR, FGF2, FGF12, BMP5 and SMAD6 genes in the ES samples were lower than those of the DS samples (P-values ≤0.05 and fold change of methylation ratios ≥2). Conversely, the methylation ratios of the EGFR, TGFBR2, IGF2BP1 and MMD2 genes increased in the ES samples compared with the DS samples. In addition, 223 differentially methylated genes were found in the GnRH signalling pathway (KO04912), ovarian steroidogenesis pathway (KO04913), oestrogen signalling pathway (KO04915), oxytocin signalling pathway (KO04921), insulin secretion pathway (KO04911) and MAPK signalling pathway (KO04010).ConclusionsThis study is the first large-scale comparison of the high-resolution DNA methylation landscapes of oestrous and dioestrous ovaries from dairy goats. Previous studies and our investigations have shown that the NR5A2, STAR, FGF2 and BMP5 genes might have potential application value in regulating caprine oestrus.Electronic supplementary materialThe online version of this article (10.1186/s40104-018-0301-x) contains supplementary material, which is available to authorized users.

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The role of FSH and TGF-β superfamily in follicle atresia

Cited by 65 publications

References 135 publications

A Preliminary Study on the Characteristics of microRNAs in Ovarian Stroma and Follicles of Chuanzhong Black Goat during Estrus

A Preliminary Study on the Characteristics of microRNAs in Ovarian Stroma and Follicles of Chuanzhong Black Goat during Estrus

High follicle‐stimulating hormone levels accelerate cartilage damage of knee osteoarthritis in postmenopausal women through the PI3K/AKT/NF‐κB pathway

Genome-wide differences in DNA methylation changes in caprine ovaries between oestrous and dioestrous phases

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