2020
Abstract: Knee osteoarthritis (KOA) is prevalent in postmenopausal women and a cause of pain and disability in elderly populations. Here, we report high follicle‐stimulating hormone (FSH) levels across postmenopausal female KOA patients aged 50–60 years. We speculate FSH might damage cartilage tissues through the phosphoinositide 3‐kinase/AKT/nuclear factor kappa B pathway. Our findings suggest that FSH modulation holds promise as a novel treatment for postmenopausal female KOA patients aged 50–60 years.
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2021
2021
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Cited by 2 publications
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References 35 publications
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“…It is plausible that single hormones, such as PDGF and follicle-stimulating hormone (FSH), among others, which become elevated with age, have ubiquitous functions. High serum FSH levels, for example, associate not only with bone loss, but also with obesity, hyperlipidemia, osteoarthritis, and neurodegeneration (17)(18)(19)(20). Likewise, play a shift from contractile to a dedifferentiated, synthetic phenotype, resulting in intimal and medial thickening, elevated collagen/elastin ratio in the arterial wall, and increased mechanical vessel rigidity and stiffness (14).…”
Section: Discussionmentioning
confidence: 99%
“…It is plausible that single hormones, such as PDGF and follicle-stimulating hormone (FSH), among others, which become elevated with age, have ubiquitous functions. High serum FSH levels, for example, associate not only with bone loss, but also with obesity, hyperlipidemia, osteoarthritis, and neurodegeneration (17)(18)(19)(20). Likewise, play a shift from contractile to a dedifferentiated, synthetic phenotype, resulting in intimal and medial thickening, elevated collagen/elastin ratio in the arterial wall, and increased mechanical vessel rigidity and stiffness (14).…”
Section: Discussionmentioning
confidence: 99%
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