The role of extracellular matrix metalloproteinases and their inhibitors in allergic diseases

Kuźmiński, Andrzej; Przybyszewski, Michał; Graczyk, Małgorzata; Bartuzi, Zbigniew

doi:10.5114/pdia.2012.31493

Cited by 7 publications

(7 citation statements)

References 32 publications

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“…The activation of TGF-β is mediated by thrombospondin, plasmin, integrins and THY-1 (CD90), as well as matrix metalloprotease 9. Not only is TGF-β believed to initiate the production of extracellular matrix components (including collagen, fibronectin and proteoglycans) but also it inhibits their degradation due to interactions with matrix metalloproteinases and stimulation of synthesis of their inhibitors [ 12 , 16 , 17 ]. It has been shown that TGF-β increases fibroblast susceptibility for apoptosis [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Transforming growth factor-β1 in plaque morphea

Dańczak‐Pazdrowska¹,

Kowalczyk²,

Szramka-Pawlak³

et al. 2013

pdia

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IntroductionMorphea (localized scleroderma) is a rare cutaneous disease characterized by skin fibrosis of unknown pathogenesis. Transforming growth factor-β (TGF-β) is a potent profibrotic factor. The role of TGF-β in morphea remains unclear.AimThe goal of this study was to estimate the expression level of TGF-β1 in skin and peripheral blood mononuclear cells as well as the plasma levels of TGF-β1 in plaque morphea (MEP).Material and methodsThe study involved 20 MEP patients. Three control groups were involved: 1 – plasma: 36 healthy volunteers; 2 – PBMC: 47 healthy volunteers; 3 – skin biopsies: 13 samples collected during mastectomy (breast cancer was not skin involved). The analysis of TGF-β1 plasma levels was performed with the use an adequate ELISA kit, while real-time polymerase chain reaction was employed for the expression of TGF-β1 in peripheral blood mononuclear cells (PBMC) and skin.ResultsIn our study we have not detected differences in TGF-β 1 expression in PBMC, skin, nor in plasma levels of TGF-β1 between MEP patients and healthy controls, regardless of disease activity and its duration.ConclusionsThe results of our study contradict the claim of the substantial role of TGF-β1 in the most common morphea subtype – MEP.

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Section: Introductionmentioning

confidence: 99%

Transforming growth factor-β1 in plaque morphea

Dańczak‐Pazdrowska¹,

Kowalczyk²,

Szramka-Pawlak³

et al. 2013

pdia

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“…Korostoff et al [8] demonstrated an expression of latent forms of MMP-2 and MMP-9 in gingival biopsies taken from healthy individuals and patients with periodontitis. In turn, the active form of MMP-2 was present only in material collected from patients with periodontitis [9].…”

Section: Mediators Of Inflammation In Periodontal Diseasesmentioning

confidence: 99%

Markers of inflammation in periodontal diseases

Nędzi-Góra¹,

Kostrzewa-Janicka²,

Górska³

2013

cejoi

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“…Numerous MMPs, including MMP-2, participate in many physiologic processes, such as embryogenesis, angiogenesis, connective tissue regeneration. Metalloproteinases activity increases in many pathologic conditions, such as malignancies, autoimmune diseases, cardiovascular diseases, inflammatory diseases, skin diseases (dermatitis herpetiformis, pemphigus vulgaris, bullous pemphigoid, atopic dermatitis) and allergic diseases (bronchial asthma, urticaria, allergic rhinitis) [ 5 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of skin patch test results and metalloproteinase-2 levels in a patient with contact dermatitis

Wojciechowska¹,

Czajkowski²,

Kowaliszyn³

et al. 2015

pdia

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IntroductionThe complex course of skin reactions that contact eczema involves is due in part to abnormalities of the extracellular matrix function. Proteins that degrade extracellular matrix components include metalloproteinases (MMP), which are divided into subcategories depending on the chemical structure and substrate specificity.AimTo analyse patch test results in contact dermatitis patients and to assess MMP-2 levels during skin lesion exacerbation and remission.Material and methodsFifty patients suffering from contact eczema were qualified to the study and 20 healthy volunteers as a control group. The study group patients had epidermal skin tests performed with the “European Standard” set. To assess the MMP-2 level in serum, venous blood was drawn, twice from study group patients – during contact dermatitis exacerbation and remission periods – and once from control group patients. Assessment of MMP-2 in serum was done with ELISA immunoassay. To verify the proposed hypotheses, parametric and nonparametric significance tests were used.ResultsHands were the most frequent location of contact dermatitis. Nickel (II) sulphate was the most frequent sensitizing substance. Mean MMP-2 levels were statistically higher in the study group both in contact dermatitis exacerbation and remission periods than in the control group. There was no statistically significant difference between MMP-2 levels and skin patch test results.ConclusionsNickel is one of the most allergenic contact allergens in patients with contact dermatitis. Metalloproteinase-2 is a good marker of contact dermatitis in various stages of the disease.

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The role of extracellular matrix metalloproteinases and their inhibitors in allergic diseases

Cited by 7 publications

References 32 publications

Transforming growth factor-β1 in plaque morphea

Transforming growth factor-β1 in plaque morphea

Markers of inflammation in periodontal diseases

Analysis of skin patch test results and metalloproteinase-2 levels in a patient with contact dermatitis

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