Markers of inflammation in periodontal diseases

Nędzi-Góra, Małgorzata; Kostrzewa-Janicka, Jolanta; Górska, Renata

doi:10.5114/ceji.2013.37746

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…GCF is an exudate from periodontal tissue and assessment of biomarkers in GCF has been introduced as a non-invasive method to monitor the progression of periodontal diseases. 12,13 IL-17 is emerging as potentially important players in pathogenesis of periodontitis. IL-17 is of particular interest in the pathogenesis of periodontitis because of its involvement in both inflammation and protective antimicrobial immunity.…”

Section: Discussionmentioning

confidence: 99%

Estimation of interleukin-17 levels in gingival crevicular fluid from healthy individuals, chronic gingivitis and chronic periodontitis patients using enzyme linked immunosorbent assay

2020

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Background: Chronic Periodontitis (CP) is an infectious disease resulting in inflammation of supporting tissues of the teeth. A number of pro-inflammatory cytokines are formed against periodontopathogenic microorganisms. Interleukin-17 (IL-17) is a pro-inflammatory cytokine, implicated in numerous inflammatory and autoimmune conditions.Methods: A total of 25 periodontally healthy subjects (Group 1), 25 patients with gingivitis (Group 2) and 25 patients with CP (Group 3) were included for the study based on clinical examination. Gingival index, probing pocket depth and clinical attachment loss were recorded in all subjects.Results: The levels of IL-17 increased from healthy to gingivitis to periodontitis patients. A positive correlation was found with the IL-17 and the clinical parameters like gingival index, probing pocket depth and clinical attachment loss.Conclusions: There is a strong association between the levels of IL-17 with periodontal disease as well as with its severity and its possible use as a biomarker for inflammatory periodontal disease.

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Section: Discussionmentioning

confidence: 99%

Estimation of interleukin-17 levels in gingival crevicular fluid from healthy individuals, chronic gingivitis and chronic periodontitis patients using enzyme linked immunosorbent assay

2020

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“…The periodontal activity is mainly mediated by immune responses and a complex network of inflammatory mediators. Gingival crevicular fluid is an exudate from periodontal tissues and the assessment of biomarkers in GCF has been introduced as a non-invasive method to monitor the progression of periodontal diseases [ 29 , 30 ]. In a systematic review, a chemokine/cytokine profile in the GCF of aggressive and chronic periodontitis was compared.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-17 and interleukin-23 levels in gingival crevicular fluid of patients with chronic and aggressive periodontitis

Sadeghi

Sattari

Dehghan

et al. 2018

cejoi

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IntroductionInterleukin-17 is a pro-inflammatory cytokine with a wide range of protective and destructive effects in periodontitis. The role of IL-23 is stabilisation and expansion of Th-17. The aim of this study was to assess whether patients with aggressive and chronic periodontitis exhibit different gingival crevicular fluid (GCF) concentrations of IL-17 and IL-23 compared with clinically healthy subjects.Material and methodsGCF samples were obtained from 32 patients: 10 with chronic periodontitis (CP), 12 with aggressive periodontitis (AgP), and 10 healthy controls (HC). IL-23 and IL-17 concentrations were measured using enzyme-linked immunosorbent assay (ELISA). Comparison of study groups was performed with ANOVA and Tukey HSD tests. Spearman’s correlation coefficient was used to assess correlations between the variables.ResultsIL-17 concentration was significantly higher in the healthy group compared to the AgP and CP groups (p < 0.001), but there were no significant differences between the CP and AgP groups. IL-23 levels in the healthy group were significantly higher than that in the AgP group (p < 0.001). Cytokine concentrations did not correlate significantly with probing depths and clinical attachment levels.ConclusionsGingival crevicular fluid concentrations of IL-17 and IL-23 were significantly higher in the healthy group compared to periodontitis groups.

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“…Different inflammatory mediators associated with CP have been identified in body fluids 6 . Bacterial accumulations present in periodontitis are supposed to stimulate host cells by means of Toll‐like receptors (TLRs) and proinflammatory cytokines such as interleukin (IL)‐18 7 .…”

Section: Methodsmentioning

confidence: 99%

Correlation of Toll‐Like Receptor 4, Interleukin‐18, Transaminases, and Uric Acid in Patients With Chronic Periodontitis and Healthy Adults

Banu

Jabir

Mohan

et al. 2015

Journal of Periodontology

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Markers of inflammation in periodontal diseases

Abstract: Abstract

Cited by 4 publications

References 32 publications

Estimation of interleukin-17 levels in gingival crevicular fluid from healthy individuals, chronic gingivitis and chronic periodontitis patients using enzyme linked immunosorbent assay

Estimation of interleukin-17 levels in gingival crevicular fluid from healthy individuals, chronic gingivitis and chronic periodontitis patients using enzyme linked immunosorbent assay

Interleukin-17 and interleukin-23 levels in gingival crevicular fluid of patients with chronic and aggressive periodontitis

Correlation of Toll‐Like Receptor 4, Interleukin‐18, Transaminases, and Uric Acid in Patients With Chronic Periodontitis and Healthy Adults

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