The Role of Endometrial Volume and Endometrial and Subendometrial Vascularization Parameters in a Frozen Embryo Transfer Cycle

Mayer, RB; Ebner, Thomas; Weiss, Christoph; Allerstorfer, C; Altmann, R; Oppelt, Peter; Shebl, Omar

doi:10.1177/1933719118804421

Cited by 13 publications

(17 citation statements)

References 21 publications

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“…In this study, as in our study, the highest rate of OPR pregnancy belonged to women with multi-focal blood flow in the endometrium [12]. In another study by Sardana et al [7]. the results showed that groups with more endometrial blood supply had better pregnancy outcomes.…”

Section: Discussionsupporting

confidence: 76%

“…Endometrial and sub-endometrial blood flows can be measured more reliably and objectively with threedimensional power Doppler ultrasound (3D-PDU). However, contradictory outcomes have been reported due to their function in predicting pregnancy in IVF process [6][7]. Due to the fact that functional ultrasound imaging is available, non-invasive and relatively inexpensive techniques, as well as the effective role of endometrial parameters, including endometrial thickness, endometrial pattern, endometrial volume, and endometrial blood flow, the present study aimed to evaluate the effect of endometrial and subendometrial blood flows, endometrial volume and endometrial thickness on endometrial receptivity in the FET cycles.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness the perfusion of Endometrial and Subendometrial and Endometrial volume on the endometrial receptivity of FET Cycles

Hazari¹,

Sarvi²,

Alyasin³

et al. 2021

JOGRS

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Objective: this study was effects of endometrial and subendometrial blood perfusion and endometrial volume on endometrial receptivity in frozen embryo transfer (FET) cycles. Materials and methods: This prospective observational cohort study, that on infertile women who referred for FET to Shariati Hospital and Omid Infertility Clinic in Tehran (Iran) .112 patients selected among eligible women with good quality embryos. After homogenization, participants underwent endometrial preparation for hormone replacement therapy (HRT) according to a similar routine protocol. On the day of the FET, they underwent a thorough ultrasound examination for possible effective parameters. Subsequently, one to two good quality blastocysts were transferred, and the pregnancy outcomes were monitored. Results: In vitro fertilization (IVF) was performed on 112 patients with a mean age of 33.93±4.93 years. Although, serum β-HCG level was used to confirm pregnancy. Accordingly, out of 112 participating patients, 50 (44.6%) became pregnant after IVF. Based on the results of this study, the endometrial blood flow was significantly different between the two groups of pregnant and non-pregnant women, so that a higher pregnancy rate was observed in participants with multi-focal and spare endometrial blood flows (P<0.05). Additionally, a significant relationship between endometrial blood flow and pregnancy outcome so that there was more ongoing pregnancy rates in those with multi-focal and spare endometrial blood flows (P<0.05). But the endometrial variables of volume, length, width, thickness and pattern were not significantly different between the two groups of pregnant and non-pregnant women. Moreover, contextual parameters had no significant relationship with pregnancy outcome (P>0.05). Endometrial measurement indices were also ineffective on pregnancy outcomes and no significant difference was there between the groups (P>0.05). Conclusion: Collectively, the endometrial blood flow can play an effective role in improving pregnancy event and its stability after IVF, but the endometrial volume was unable to predict pregnancy event and its stability after IVF.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Effectiveness the perfusion of Endometrial and Subendometrial and Endometrial volume on the endometrial receptivity of FET Cycles

Hazari¹,

Sarvi²,

Alyasin³

et al. 2021

JOGRS

View full text Add to dashboard Cite

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“…The relationship between endometrial volume at the embryo transfer day and pregnancy rates has also been studied, with contradictory results. Some of the studies showed a correlation between increased endometrial volume and pregnancy rates (11,12), whereas another study showed no significant association between endometrial volume and clinical pregnancy outcome (8). None of those studies compared the late follicular phase endometrial volume with the volume before embryo transfer.…”

Section: Figurementioning

confidence: 99%

Endometrial compaction (decreased thickness) in response to progesterone results in optimal pregnancy outcome in frozen-thawed embryo transfers

Haas

Smith

Zilberberg

et al. 2019

Fertility and Sterility

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Objective: To evaluate whether the change in endometrial thickness between the end of the estrogen phase and the day of embryo transfer has an impact on the pregnancy rate in frozen-thawed embryo transfer (FET) cycles. Design: Retrospective observational cohort study. Setting: Single tertiary care medical center. Patient(s): Ultrasound images in 274 FET cycles were reviewed. All patients underwent endometrial preparation with the use of hormonal therapy. Interventions(s): Ultrasound measurements of endometrial thickness at the end of the estrogen phase and the day of embryo transfer. Main Outcome Measure(s): The change in endometrial thickness and ongoing pregnancy rate. Result(s): We calculated the ongoing pregnancy rate in patients whose endometrial thickness decreased (compacted) after starting progesterone by 5%, 10%, 15%, or 20% compared with patients with no change or increased endometrial thickness. The ongoing pregnancy rate was significantly increased at all levels of compaction compared with no compaction. The ongoing pregnancy rate showed a significant increase with each decreasing quartile of change in thickness (increased percentage of compaction) in the progesterone phase compared with the estrogen phase. Conclusion(s):There is a highly significant inverse correlation between the ongoing pregnancy rate and the change of endometrial thickness between the end of estrogen administration and the day of embryo transfer (Fertil Steril Ò 2019;112:503-9. Ó2019 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

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“…Several studies have suggested that endometrial vasculature indices in a cycle are associated with endometrial receptivity [ 31 ] and the following pregnancy rates [ 32 ]. However, there is also a 30-min vaginal ultrasonography study on frozen-thawed embryo transfer cards from Austria [ 33 ], suggesting that there is a significant difference in the volume of the endometrium between the pregnant group and the non-pregnant group. As the volume increased, the pregnancy rate increased, and there was no difference in the vascularization parameters FI, VFI, VI of the endometrium and subendometrium.…”

Section: Discussionmentioning

confidence: 99%

Nomogram prediction for the prediction of clinical pregnancy in Freeze-thawed Embryo Transfer

Zhang

Wang

Zhang

et al. 2022

BMC Pregnancy Childbirth

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Background This study aimed to identify multiple endometrial receptivity related factors by applying non-invasive, repeatable multimodal ultrasound methods. Combined with basic clinical data, we further established a practical prediction model for early clinical outcomes in Freeze-thawed Embryo Transfer (FET). Methods Retrospective analysis of clinical data of infertility patients undergoing FET cycle in our Center from January 2017 to September 2019. Receiver operating characteristic (ROC) curve and decision curve analyses were performed by 500 bootstrap resamplings to assess the determination and clinical value of the nomogram, respectively. Results A total of 2457 FET cycles were included. We developed simple nomograms that predict the early clinical outcomes in FET cycles by using the parameters of age, BMI, type and number of embryos transferred, endometrial thickness, FI, RI, PI and number of endometrial and sub-endometrial blood flow. In the training cohort, the area under the ROC curve (AUC) showed statistical accuracy (AUC = 0.698), and similar results were shown in the subsequent validation cohort (AUC = 0.699). Decision curve analysis demonstrated the clinical value of this nomogram. Conclusions Our nomogram can predict clinical outcomes and it can be used as a simple, affordable and widely implementable tool to provide guidance and treatment recommendations for FET patients.

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The Role of Endometrial Volume and Endometrial and Subendometrial Vascularization Parameters in a Frozen Embryo Transfer Cycle

Cited by 13 publications

References 21 publications

Effectiveness the perfusion of Endometrial and Subendometrial and Endometrial volume on the endometrial receptivity of FET Cycles

Effectiveness the perfusion of Endometrial and Subendometrial and Endometrial volume on the endometrial receptivity of FET Cycles

Endometrial compaction (decreased thickness) in response to progesterone results in optimal pregnancy outcome in frozen-thawed embryo transfers

Nomogram prediction for the prediction of clinical pregnancy in Freeze-thawed Embryo Transfer

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