The Role of Dates (Phoenix dactylifera) Aqueous Extract in Improving the Plasma Lipid Profiles of Diet-Induced Hypercholesterolemic Rabbits

Hasan, Nawal S.; Amom, Zulkhairi H.; Nor, A. I.; Arapoc, Daryl Jesus; Azlan, Azrina

doi:10.3923/rjbsci.2010.632.637

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…Even as there was insignificant increase in serum HDL-C compared to Dox group (Table 2). These findings were in agreement with previous studies of Alsaif et al [51] and Hasan et al [52] who reported that the supplementation with date palm fruit reduced the concentrations of TC, TG, and LDL-C while caused elevation in levels of HDL-C in hypercholesterolemic hamsters and rabbit, respectively. In addition, date palm fruit extract treatment improved the changes in lipid profile in mice infected with the Eimeria papillata [53].…”

Section: Resultssupporting

confidence: 93%

Cardioprotective Effect of Date Palm Against Doxorubicin-Induced Cardiotoxicity

Mubarak

Hamid

Farrag

et al. 2018

Asian J Pharm Clin Res

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Objective: Doxorubicin (Dox), an anthracycline antibiotic, has been widely used to treat cancer, principally hematological malignancies, and solid tumors. The administration of Dox is a topic of concern in the medical community, as it frequently related to dose-dependent cardiotoxicity. Therefore, the present study was designed to investigate the protective potential of date palm fruit extract on Dox-induced cardiotoxicity.Methods: A total of 40 female albino rats were used in this study and classified into four groups including control, date palm fruit extract, Dox, and treated date palm fruit extract groups.Results: Dox produced a significant increase in creatine kinase-MB and lactate dehydrogenase activities. It also decreased the activities of cardiac glutathione peroxidase and superoxide dismutase but increase levels of cardiac malondialdehyde and also of urinary 8-hydroxy-2-deoxyguanosine. Myocardial toxicity of Dox also appeared in the elevation of serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, while level of high-density lipoprotein cholesterol decreased. Histopathological studies revealed alteration of cardiac tissue structure by Dox. Treatment with date palm fruit extract restored the aforementioned parameters.Conclusion: Date palm fruit exhibits a cardioprotective influence on the heart tissue against toxicity induced by Dox.

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Section: Resultssupporting

confidence: 93%

Cardioprotective Effect of Date Palm Against Doxorubicin-Induced Cardiotoxicity

Mubarak

Hamid

Farrag

et al. 2018

Asian J Pharm Clin Res

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“…[ 35 36 ] In another study, it was demonstrated that DP aqueous extract improves the plasma lipid profiles of the diet induced hypercholesterolemic rabbits through the augmentation of specific biosynthesis of antioxidant enzymes. [ 37 ] Consistent with these studies, our study showed that P. dactylifera is able to mitigate I/R injury induced by T/D in rat testis.…”

Section: Discussionsupporting

confidence: 89%

Short-term effects of date palm extract (Phoenix dactylifera) on ischemia/reperfusion injury induced by testicular torsion/detorsion in rats

et al. 2017

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Background:Antioxidants are potent scavengers of free radicals and have beneficial effects on human health.Objective:The aim of this study was to investigate the potential protective antioxidant activity of the edible portion of date fruit extract in an experimental testicular torsion/detorsion (T/D) model in rats.Materials and Methods:To investigate the potential protective effects of date palm (DP), 30 male Spraque-Dawley rats were divided into three groups: sham-operated, T/D, and T/D + DP-treated (500 mg/kg, PO) groups. Testicular ischemia was induced via keeping the left testis under 720° clockwise torsion for 2 h (h), afterward, detorsion was performed. All rats were sacrificed 4 h after detorsion. Serum malondialdehyde (MDA) concentration, total oxidative status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and histopathological damage score were evaluated.Results:Serum MDA, TOS, and OSI levels rose significantly in the T/D group. These values were lower in the T/D + DP group. TAS values decreased significantly in T/D group and rose in T/D + DP group. Severe injury was seen in the twisted testes of T/D group. In contrast, ipsilateral-twisted testicular tissue in the DP-treated group showed moderate-to-mild changes. Contralateral testicular tissue in the T/D group had a mild-to-moderate tissue injury; meanwhile, treated group revealed normal-to-mild changes. Spermatogenesis was significantly improved in DP-treated group when compared with the T/D group.Conclusion:The findings suggest a possible protective effect of DP against testicular oxidative damage induced by T/D; however, more detailed studies are warranted.SUMMARYGiven the presence of several phenolic compounds possessing high antioxidant activity in DP, it could potentially be used to reduce testis ischemia/reperfusion-induced damage.Abbreviations Used: TAS: Total antioxidant status,TOS: Total oxidative status; OSI: Oxidative stress index; MDA: Malondialdehyde; C: Congestion; H: Hemorrhage, E: Edema; SG: Sloughed germinal cells; SA: Spermatogenesis arrest; STD: Seminiferous tubules disorganization; STA: Seminiferous tubules atrophy; G: Giant cells; T/D: Torsion/detorsion; DP: Date palm

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“…Moreover, flavonoids in the seed might also play a role in boosting the activity of lecithin cholesterol acyl transferase (LCAT), which regulates blood lipids (Senecha et al,2012).In addition, P. dactylifera seeds contain high amounts of fiber. Adequate intake of dietary fiber can lower the serum cholesterol level, risk of coronary heart disease, hypertension, constipation, diabetes, colon and breast cancer (Ishida et al,2000).This is in agreement with Hasan et al (2010), who recorded that supplementation with date palm fruit reduced the concentrations of total cholesterol (TC), TAG, and LDL-c while caused elevation in levels of HDL-c in hypercholesterolemic hamsters and rabbits. Treatment with Amaryl to diabetic rats showed a significant decrease in serum TC,TAG, LDL-c, with significant increase in HDL-c all over the periods of the experiments, and that may be due to Glimepiride influence on the lipid profile a significant feature associated with hypoglycemic effect.…”

Section: Discussionsupporting

confidence: 78%

Ameliorative effect of Sukkari date extract on STZ induced experimentally diabetes in male rats

Elbably

Elhamid

El-Nahas

2019

Benha Veterinary Medical Journal

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This study evaluated the protective effect of Sukkari date extract on Streptozotocin(STZ)induced diabetes in rats. Forty male albino rats were divided into 2 main groups: Group I (Control group, n=10): received no drugs and served as control. Group II (Diabetic group, n=30):received a single dose of STZ (50mg/kg b.wti.p.) for induction of diabetes, and 48hoursafterdiabetes induction,the rats were divided into 3 equal subgroups. Subgroup (a): Diabetic non-treated rats.Subgroup (b): Diabetic aqueous sukkari date extract-treated rats.Subgroup (c): DiabeticAmaryl-treated rats. Treatment with sukkari date extract(10 ml/rat/day) and Amaryl(1ml/rat/day) were given orally and daily for 60 days. Blood samples and liver tissues were collected from all animals once after 60 days of treatment for determination of serum glucose, lipids profile, insulin,L-malondialdehyde (L-MDA), superoxide dismutase (SOD) and 8-hydroxy-2-deoxyguanosine (8-OHdG) inaddition to paraoxonase 1 (PON1) gene expression level in liver tissue. The obtained results showed a significant increase in serum glucose, total cholesterol, triacylglycerols, low density lipoprotein-cholesterol (LDL-c), L-MDA and 8-OHdG levels with marked decrease in serum insulin, high density lipoprotein-cholesterol (HDL-c) and SOD activity in addition to significant down-regulation of PON1 gene expression level in liver in STZ-induced diabetic rats.On the other hand, treatments of diabetic rats with aqueous sukkari date extract or amaryl exhibited a significant ameliorative effect on all previous biomarkers and approximately reach to normal levels. This study suggest the ameliorativerole of aqueous sukkari date extract in diabetes and its protective effect may be mediated through reduction in oxidative stress, the promising hypoglycemic and hypolipidemic activity.

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The Role of Dates (Phoenix dactylifera) Aqueous Extract in Improving the Plasma Lipid Profiles of Diet-Induced Hypercholesterolemic Rabbits

Cited by 6 publications

References 11 publications

Cardioprotective Effect of Date Palm Against Doxorubicin-Induced Cardiotoxicity

Cardioprotective Effect of Date Palm Against Doxorubicin-Induced Cardiotoxicity

Short-term effects of date palm extract (Phoenix dactylifera) on ischemia/reperfusion injury induced by testicular torsion/detorsion in rats

Ameliorative effect of Sukkari date extract on STZ induced experimentally diabetes in male rats

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