Objective: Doxorubicin (Dox), an anthracycline antibiotic, has been widely used to treat cancer, principally hematological malignancies, and solid tumors. The administration of Dox is a topic of concern in the medical community, as it frequently related to dose-dependent cardiotoxicity. Therefore, the present study was designed to investigate the protective potential of date palm fruit extract on Dox-induced cardiotoxicity.Methods: A total of 40 female albino rats were used in this study and classified into four groups including control, date palm fruit extract, Dox, and treated date palm fruit extract groups.Results: Dox produced a significant increase in creatine kinase-MB and lactate dehydrogenase activities. It also decreased the activities of cardiac glutathione peroxidase and superoxide dismutase but increase levels of cardiac malondialdehyde and also of urinary 8-hydroxy-2-deoxyguanosine. Myocardial toxicity of Dox also appeared in the elevation of serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, while level of high-density lipoprotein cholesterol decreased. Histopathological studies revealed alteration of cardiac tissue structure by Dox. Treatment with date palm fruit extract restored the aforementioned parameters.Conclusion: Date palm fruit exhibits a cardioprotective influence on the heart tissue against toxicity induced by Dox.

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Background: Endovenous laser ablation (EVLA)and radiofrequency ablation(RFA)are both associated with excellent technical, clinical, and patient-reported outcomes for the treatment of varicose veins. Aim: to compare endovenous laser ablation and radiofrequency ablation in the treatment of primary long saphenous varicose veins. Patients and Method: 40 patients scheduled for treatment of varicose veins were included and were divided randomly into 2 equal groups. Endovenous laser ablation was used for the first group and compared to a second group treated with Radiofrequency ablation. The success rate and postoperative results of both groups were compared to each other. Results: closure rate in EVLA group was 100% and in RFA group was 80%, radiofrequency ablation, and EVLA complications: skin burn 5% and 0 %, hyperpigmentation 10% and 0 %, and groin hematoma 0% and 5% respectively. Conclusion: EVLA procedure seems to be superior to RFA in the treatment of long saphenous varicose veins.