The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers

Soeroso, Noni Novisari; Zain-Hamid, Rozaimah; Sinaga, Bintang Yinke Magdalena; Sadewa, Ahmad Hamim; Syafiuddin, Tamsil; Syahruddin, Elisna; Tann, Gino; Mutiara, E.

doi:10.3889/oamjms.2018.224

Cited by 10 publications

(12 citation statements)

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“…The Brinkman index in this study found that 75.7% of subjects were heavy smokers, 20% were moderate smokers, and the other 4.3% were light smokers. A similar result was also found by Soeroso et al, [ 15 ], [ 16 ] in which 52.9% of their research participants were categorised as heavy smokers. Also, this study was to evaluated nicotine dependence based on the Fagerstrom Tolerance Questionnaire (mFTQ), and the results showed that 65% of Fagerstrom scores were very high.…”

Section: Discussionsupporting

confidence: 89%

“…Globally, cigarettes are one of the biggest death factors with a 1:10 ratio in adults and a mortality rate of about 5 million people per year [ 14 ]. Similarly, a study conducted by Soeroso in 2018 showed that 60% of lung cancer cases suffered by patients aged 55-64 years [ 15 ], [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…This study found that the most common type of lung cancer found in Batak tribe in Indonesia was adenocarcinoma (92.9%), and the most consumed cigarette type was clove cigarettes. Clove cigarettes contain clove that will make smokers suck in more deeply; thus, smokes containing carcinogenic substances eventually enter the peripheral respiratory tract [ 16 ], [ 18 ]. Syahruddin et al, [ 19 ] found that the EGFR mutations rate among Indonesian population reached 57.1% common mutations (exon 19 ins/dels, L858r) and about 29% uncommon mutations (G719X, exon 20 ins, T790M, L861Q).…”

Section: Discussionmentioning

confidence: 99%

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Procalcitonin Level in Non-Small Cell Lung Cancer Patients among Indonesian Population

Soeroso¹,

Tanjung²,

Afiani³

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:Serum Procalcitonin (PCT) is a biomarker that is frequently used to diagnose an infection. In some cases of thoracic malignancy, procalcitonin level appears to increase. However, the role of procalcitonin to diagnose malignancy is not certain yet, and the causes have not been known.AIM:This study aimed to investigate procalcitonin levels in non-small cell lung cancer patients.METHODS:This was an observational study with a cross-sectional design. All lung cancer patients did not diagnose based on cytology/histopathology results with no evidence nor were signs and symptoms of infection recruited through consecutive sampling. The subtypes of lung cancer include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma, staged III and IV. The procalcitonin levels were analysed from blood using immunofluorescent assay. Data were then analysed with the Chi-Square test by Epi Info™ 7 programs in which p-value < 0.05 was considered statistically significant.RESULTS:A total of 68 lung cancer patients fulfilled the criteria of this study, 55 men (80.9%) and 13 women (19.1%). The highest percentage of cytology/histopathology type found was adenocarcinoma (80.9%), and 60.3% of those were diagnosed in stage IV. An increased procalcitonin level (greater than 0.01 ng/mL) occurred in 80.9% of Non-Small Cell Lung Cancer (NSCLC) patients. It appears that the higher the stage of lung cancer, the lower procalcitonin levels would be, although it was not statistically significant. There was no association between lung cancer subtype with procalcitonin levels.CONCLUSION:An increased level of procalcitonin may be an indication not only for infection but also for Non-Small Cell Lung Cancer.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Procalcitonin Level in Non-Small Cell Lung Cancer Patients among Indonesian Population

Soeroso¹,

Tanjung²,

Afiani³

et al. 2018

Open Access Maced J Med Sci

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“…Lung cancer found in the case was the adenocarcinoma type. A study by Soeroso et al [ 11 , 12 ] showed that the cytologic/histopathologic type which was mostly found was adenocarcinoma with approximately 92.9% compared with squamous cell carcinoma with approximately 7.1%. A proper enforcement of the diagnosis will be able to provide fast treatment so that the patient's quality of life will be better.…”

Section: Discussionmentioning

confidence: 99%

Lung adenocarcinoma presenting with an orbital metastasis

Soeroso

Tarigan

Saragih

et al. 2018

Respiratory Medicine Case Reports

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Orbital metastasis of lung adenocarcinoma is very rare. The incidence is only found to be approximately 7%–12% of lung cancer cases. The lack of knowledge about orbital metastasis results in misdiagnosis between malignant or benign lesion. This was a case of a 39-year-old woman complaining about a protruding left eye and a blind pain in the left eye characterized by hyperemesis eyeball. A CT scan of the orbital showed a soft tissue tumor in the fronto-naso-superomedial area of the left orbital with suspicion of infiltration of the medial rectus muscle, left bulbus oculi, lamina papyracea, and left frontal sinus wall which causes proptosis and soft tissue tumor in the left temporal region with suspicion of infiltration in the left sphenoid wing with an impression of metastasis. A Fine Needle Aspiration Biopsy (FNAB) in the temporal and intra-orbital region showed metastatic adenocarcinoma. Moreover, findings of the chest x-ray and chest CT scan concluded that there was a tumor in the left lung, and a bronchoscopy found adenocarcinoma as the biopsy results.

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“…This may translate into inter-individual differences in the concentration of nicotine in the body and to differences in the number of cigarettes consumed by smokers [ 17 ]. For example, CYP2A6 reduced activity gene variants are associated with reduced lung cancer risk in smokers [ 18 , 19 ] and nicotine dependence [ 20 , 21 ] in different populations. While this variants are associated to increased risk for tobacco-related cancers in humans [ 22 – 24 ], they also can affect smoking-frequency, nicotine clearance, and data interpretation of tobacco use [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic variants in CYP2A6 and UGT1A9 genes associated with urinary nicotine metabolites in young Mexican smokers

et al. 2020

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Nicotine is the major pharmacologically active substance in tobacco. Several studies have examined genotypes related to nicotine metabolism, but few studies have been performed in the Mexican population. The objective was to identify associations between gene variants in metabolizing enzymes and the urinary levels of nicotine metabolites among Mexican smokers. The levels of nicotine and its metabolites were determined in the urine of 88 young smokers from Mexico, and 167 variants in 24 genes associated with nicotine metabolism were genotyped by next-generation sequencing (NGS). Trans-3′hydroxy-cotinine (3HC) and 4-hydroxy-4-(3-pyridyl)-butanoic acid were the most abundant metabolites (35 and 17%, respectively). CYP2A6*12 was associated with 3HC (p = 0.014). The rs145014075 was associated with creatinine-adjusted levels of nicotine (p = 0.035), while the rs12471326 (UGT1A9) was associated to cotinine-N-glucuronide (p = 0.030). CYP2A6 and UGT1A9 variants are associated to nicotine metabolism. 4HPBA metabolite was an abundant urinary metabolite in young Mexican smokers.

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The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers

Cited by 10 publications

References 6 publications

Procalcitonin Level in Non-Small Cell Lung Cancer Patients among Indonesian Population

Procalcitonin Level in Non-Small Cell Lung Cancer Patients among Indonesian Population

Lung adenocarcinoma presenting with an orbital metastasis

Genetic variants in CYP2A6 and UGT1A9 genes associated with urinary nicotine metabolites in young Mexican smokers

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