The Role of Chemokines in Psoriasis—An Overview

Zdanowska, Natalia; Kasprowicz-Furmańczyk, Marta; Placek, Waldemar; Owczarczyk‐Saczonek, Agnieszka

doi:10.3390/medicina57080754

Cited by 31 publications

(26 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In inflammatory processes, they act through their receptors and influence the migration of immune system cells. By participating in the activation of T lymphocytes, neutrophils and macrophages as well as their recruitment to the site of inflammation, chemokines seem to play a significant role in the pathogenesis of chronic inflammatory skin diseases, such as PsO [ 13 , 14 ]. Moreover, it is postulated that chemokines may also be involved in the aetiology of pruritus [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and Pruritus

Purzycka-Bohdan

Nedoszytko

Zabłotna

et al. 2022

IJMS

View full text Add to dashboard Cite

Psoriasis (PsO) is a chronic, immune-mediated, inflammatory skin disease associated in most cases with pruritus. Chemokines seem to play a significant role in PsO pathogenesis. The aim of the study was to analyse serum concentrations of CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, CCL5/RANTES, CCL17/TARC, CCL18/PARC, CCL22/MDC and CXCL8/IL-8, and their correlation with PsO severity and pruritus intensity. The study included 60 PsO patients and 40 healthy volunteers. Serum concentrations of six (CCL2/MCP-1, CCL3/MIP-1α, CCL5/RANTES, CCL17/TARC, CCL18/PARC and CCL22/MDC) out of eight analysed chemokines were significantly elevated in PsO patients; however, they did not correlate with disease severity. The serum level of CCL5/RANTES was significantly higher in patients with the psoriasis area and severity index (PASI) ≥ 15 (p = 0.01). The serum concentration of CCL17/TARC correlated positively with pruritus assessed using the visual analogue scale (VAS) (R = 0.47; p = 0.05). The study indicated CCL17/TARC as a potential biomarker of pruritus intensity in PsO patients. Chemokines appear to be involved in the development of PsO systemic inflammation. Further detailed studies on the interactions between chemokines, proinflammatory cytokines and immune system cells in PsO are required to search for new targeted therapies.

show abstract

Section: Introductionmentioning

confidence: 99%

Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and Pruritus

Purzycka-Bohdan

Nedoszytko

Zabłotna

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…In psoriasis, neutrophils, after their chemotaxis, activate cutaneous endothelial cells and vies versa, and induce vascular remodeling including vasodilation and enhanced vascular permeability in psoriatic skin 24 . Also, they play a vital role in the activation and recruitment of T cells and macrophages 25 …”

Section: Discussionmentioning

confidence: 99%

“…24 Also, they play a vital role in the activation and recruitment of T cells and macrophages. 25 TNFα mediates the proliferation of keratinocytes and participates actively in inflammation resulting in tissue alteration in psoriasis. 26 Regarding IL-1β, it is a critical agent in activation and differentiation of IL-17-producing T cells.…”

Section: Discussionmentioning

confidence: 99%

S100A8 (rs3806232) gene polymorphism and S100A8 serum level in psoriasis vulgaris patients: A preliminary study

Farag

Shoaib

Labeeb

et al. 2022

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Background S100A8 single nucleotide polymorphism (SNP) and S100A8 blood level are related to many inflammatory disorders with no available conclusion in psoriasis. Aim The aim of this study was to evaluate the possible role of S100A8 in psoriasis pathogenesis through analyzing its S100A8 (rs3806232) gene polymorphism and S100A8 serum level in psoriasis vulgaris patients, in addition to correlate the detected results with severity psoriasis in those patients. Methods This case–control study was conducted on 50 patients having psoriasis vulgaris, and 26 controls. Severity of psoriasis was evaluated using psoriasis area and severity index (PASI) score. S100A8 serum level and S100A8 (rs3806232) SNP were evaluated by ELISA and polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) respectively. Results Serum S100A8 level was significantly higher in psoriatic patients than controls and was positively correlated with PASI score (r = 0.826, p < 0.001). S100A8 (rs3806232) AA genotype and A allele were significantly increased among psoriasis patients than controls (p < 0.001) increasing risk of psoriasis development by about 5, 12, and 6 times than AG, GG, and G alleles. AA genotype was significantly associated with psoriasis severity (p = 0.005) and high S100A8 serum levels (p = 0.018). Conclusions Circulating S100A8 could associated with disease severity and have an active role in psoriasis pathogenesis. S100A8 (rs3806232) SNP (AA genotype and A allele) might contribute to development and severity of psoriasis in the Egyptian population.

show abstract

“…The inflammatory infiltrate consists primarily of dendritic cells, macrophages, T cells, neutrophils in the dermis, and some T cells in the epidermis [ 5 ]. In addition, the tumor necrosis factor (TNF)-α and interferon (IFN)-γ in keratinocytes activate the inflammatory response via stimulating the secretion and synthesis of various inflammatory mediators [ 6 ]. Psoriasis can be induced via various factors in genetically susceptible individuals, including trauma, infection, and medications (such as β-blockers, IFNα, and lithium) [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Erianin-Loaded Photo-Responsive Dendrimer Mesoporous Silica Nanoparticles: Exploration of a Psoriasis Treatment Method

Liu

Zheng

et al. 2022

Molecules

View full text Add to dashboard Cite

Psoriasis is a chronic inflammatory skin disorder accompanied by excessive keratinocyte proliferation. Erianin (Eri) is an ideal drug candidate for inhibiting proliferation and inducing apoptosis in the treatment of psoriasis. However, Eri’s poor water solubility and low penetration activity across the skin hinder its application in local medicine. In this study, we developed a novel photo-responsive dendritic mesoporous silica nanoparticle-based carrier to deliver erianin, improved its bioavailability, and achieved sustained-release effects. Spiropyran (SP), 3-aminopropyltriethoxysilane (APTES), and perfluorodecyltriethoxysilane (PFDTES) were conjugated to the outer surface, which allowed Eri to be released in response to UV radiation. The physicochemical properties of photo-responsive dendritic mesoporous silica nanoparticles (Eri-DMSN@FSP) were characterized via multiple techniques, such as using a Fourier-transform infrared spectrometer, a high-resolution transmission electron microscope, and nuclear magnetic resonance (NMR) spectroscopy. The anti-proliferative properties and light-triggered release of erianin-loaded photo-responsive dendritic mesoporous silica nanoparticles were assessed via the MTT assay and a drug release study in vitro. Erianin-loaded photo-responsive dendritic mesoporous silica nanoparticles (UV) exhibit a significantly enhanced HaCat cell-inhibiting efficacy compared to other formulations, as demonstrated by their extremely low cell viability of 10.0% (concentration: 500 mg/mL), indicating their capability to release a drug that responds to UV radiation. The cellular uptake of photo-responsive dendritic mesoporous silica nanoparticles (DMSN@FSP) was observed via confocal laser scanning microscopy (CLSM). These experimental results show that Eri-DMSN@FSP could be effectively endocytosed into cells and respond to ultraviolet light to release Eri, achieving a more effective psoriasis treatment. Therefore, this drug delivery system may be a promising strategy for addressing the question of Eri’s delivery and psoriasis therapy.

show abstract

The Role of Chemokines in Psoriasis—An Overview

Cited by 31 publications

References 54 publications

Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and Pruritus

Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and Pruritus

S100A8 (rs3806232) gene polymorphism and S100A8 serum level in psoriasis vulgaris patients: A preliminary study

Erianin-Loaded Photo-Responsive Dendrimer Mesoporous Silica Nanoparticles: Exploration of a Psoriasis Treatment Method

Contact Info

Product

Resources

About