Psoriasis is a chronic inflammatory disease affecting approximately 1-3% of the general population. Although skin lesions are the primary clinical manifestation of the condition, psoriasis-especially moderate to severe-is currently regarded as a systemic disease, not only associated with the development of psoriatic arthritis but also linked to a range of other health consequences including cardiovascular complications. In view of new data on the pathogenesis of psoriasis, very rapid progress in the development of new therapeutic approaches, and in particular the registration of new drugs, a need arose to update the guidelines for the diagnosis and treatment of this nosological entity. The aim of the recommendations of the Polish Dermatological Society is to outline the most recent literature and formulate guidelines for the treatment of psoriasis that may be useful in daily dermatological practice. However, the final decision regarding the diagnostic and therapeutic procedure should always be made individually for each patient based on the patient's current clinical status and the most up-to-date scientific reports. STReSZCZeNie Łuszczyca jest przewlekłą chorobą zapalną dotyczącą około 1-3% populacji ogólnej. Choć zmiany skórne stanowią podstawową manifesta

Alopecia is caused by a variety of factors which affect the hair cycle and decrease stem cell activity and hair follicle regeneration capability. This process causes lower self-acceptance, which may result in depression and anxiety. However, an early onset of androgenic alopecia is associated with an increased incidence of the metabolic syndrome and an increased risk of the cardiac ischaemic disease. The ubiquity of alopecia provides an encouragement to seek new, more effective therapies aimed at hair follicle regeneration and neoregeneration. We know that stem cells can be used to regenerate hair in several therapeutic strategies: reversing the pathological mechanisms which contribute to hair loss, regeneration of complete hair follicles from their parts, and neogenesis of hair follicles from a stem cell culture with isolated cells or tissue engineering. Hair transplant has become a conventional treatment technique in androgenic alopecia (micrografts). Although an autologous transplant is regarded as the gold standard, its usability is limited, because of both a limited amount of material and a reduced viability of cells obtained in this way. The new therapeutic options are adipose-derived stem cells and stem cells from Wharton's jelly. They seem an ideal cell population for use in regenerative medicine because of the absence of immunogenic properties and their ease of obtainment, multipotential character, ease of differentiating into various cell lines, and considerable potential for angiogenesis. In this article, we presented advantages and limitations of using these types of cells in alopecia treatment.

Treg cells and psoriasis The amount of Treg cells in psoriasis Treg cells play a crucial role in psoriatic inflammation (5, 17). Interleukin-6, which is needed for the differentiation of Treg cells, inhibits the activation and proliferation of Th17, and leads to normalization of Treg cells and Th17 balance (1). Some researchers

Introduction: Myo-inositol and its derivatives cyclitols play an important role in the processes of cell regulation, signal transduction, osmoregulation, and ion channel physiology, and are a component of the cell membrane. Free cyclitols present in food or released during the degradation of galactosyl cyclitols by bacteria (in digestive tract) show some physiological benefits. Aim: The aim of this paper is to present and analyze the documented data about curative and healing properties of cyclitols. Results and discussion: Cyclitols are well known compounds in the treatment of an accompanied diabetes insulin resistance, and also obesity and polycystic ovarian syndrome. d-chiro-Inositol deficiency exacerbates insulin resistance in the liver, muscles, and fat, while depletion of myo-inositol results in the development of diabetic complications. Cyclitols are successfully applied in treatment of polycystic ovarian syndrome, simultaneous are observed effective reducing of BMI, improving the hormonal profile, and increasing fertility. Moreover, cyclitols have anti-atherogenic, anti-oxidative, anti-inflammatory, and anti-cancer properties. Conclusion: The properties of cyclitols may be a good therapeutic option in the reduction of metabolically induced inflammation. Due to well drugs tolerance and low toxicity of these compounds, cyclitols are recommend for pregnant women and also for children. Another advantage is their widespread presence and easy availability, which encourages their use in medicine.

Psoriasis is a chronic inflammatory skin disease affecting approximately 1-3% of the general population. Recent years have brought a considerable progress in the treatment of this dermatosis, particularly with respect to patients with moderate to severe psoriasis. A growing range of increasingly available systemic therapies poses new challenges to physicians providing care to patients with psoriasis. On account of the fact that new antipsoriatic drugs have become available on the pharmaceutical market since the publication of previous guidelines for the treatment of psoriasis, an update has become necessary. The first part of the guidelines refers to mild psoriasis and selected special forms of this disease. The aim of the recommendations of the Polish Dermatological Society is to summarize the most recent literature reports and formulate guidelines that may be potentially useful for dermatologists-venereologists in their daily clinical practice. However, the final decision regarding the diagnostic and therapeutic procedure should always be made individually for each patient based on the patient's current clinical status and the most up-to-date literature reports.