The role of central nervous system plasticity in tinnitus

Saunders, James C.

doi:10.1016/j.jcomdis.2007.03.006

Cited by 76 publications

(62 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been clearly demonstrated that tinnitus is generated in the central auditory system, possibly due to maladaptive cortical reorganization (3)(4)(5)(6)20). For instance, auditory cortex neurons that are deprived of normal thalamo-cortical input due to hearing loss do not become inactive, but "rewire" with excitatory inputs from neighboring neurons (21,22).…”

Section: Discussionmentioning

confidence: 99%

Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity

Okamoto¹,

Stracke²,

Stoll

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

232

206

View full text Add to dashboard Cite

Maladaptive auditory cortex reorganization may contribute to the generation and maintenance of tinnitus. Because cortical organization can be modified by behavioral training, we attempted to reduce tinnitus loudness by exposing chronic tinnitus patients to self-chosen, enjoyable music, which was modified ("notched") to contain no energy in the frequency range surrounding the individual tinnitus frequency. After 12 months of regular listening, the target patient group (n = 8) showed significantly reduced subjective tinnitus loudness and concomitantly exhibited reduced evoked activity in auditory cortex areas corresponding to the tinnitus frequency compared to patients who had received an analogous placebo notched music treatment (n = 8). These findings indicate that tinnitus loudness can be significantly diminished by an enjoyable, low-cost, customtailored notched music treatment, potentially via reversing maladaptive auditory cortex reorganization.cortical plasticity | human auditory cortex | lateral inhibition | magnetoencephalography | MEG S ubjective tinnitus (1) is among the most prevalent symptoms of hearing disorders in industrialized countries (2, 3). Tinnitus loudness can be considered as the most tangible tinnitus characteristic. In 1-3% of the general population, the tinnitus sensation is loud enough to affect the quality of life (4). Causal treatment strategies for tinnitus are not yet available.The lack of treatment strategies is due to incomplete knowledge concerning the mechanisms of tinnitus generation and maintenance. However, recent neurophysiological studies have shown that tinnitus is presumably caused by maladaptive auditory cortex reorganization (4-6) (similar phenomena were observed also in somatosensory cortex; refs. 7-9). For instance, magnetoencephalography (MEG) studies have demonstrated that auditory cortical map areas corresponding to the tinnitus frequency were distorted; the amount of distortion correlated positively with perceived tinnitus strength (10). Moreover, auditory cortex activity corresponding to the tinnitus frequency was shown to be enhanced and related to perceived tinnitus intrusiveness (11).To date, widely used tinnitus treatment strategies (e.g., tinnitus retraining therapy; ref. 12) are merely symptom management approaches. Therefore, there is a great demand for causal treatment approaches targeting the tinnitus percept more directly. Recent neurophysiological studies indicate that behavioral training can be a powerful means to reverse maladaptive cortical reorganization (7, 13).A previous study (14) demonstrated that listening to spectrally "notched" music can reduce cortical activity corresponding to the notch center frequency, possibly through lateral inhibition. Motivated by this finding, we developed an innovative tinnitus treatment strategy aimed at reducing tinnitus loudness. The treatment regimen consists of regular listening to enjoyable, custom-tailored notched music. Here, we evaluate and report results of the treatment from a longitudinal double-blinded ...

show abstract

Section: Discussionmentioning

confidence: 99%

Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity

Okamoto¹,

Stracke²,

Stoll

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

232

206

View full text Add to dashboard Cite

show abstract

“…Constitui-se uma morbidade importante que afeta diretamente a saúde e a vida social do indivíduo 15,26 , porém desconhecido no público pediátrico em idade escolar.…”

Section: Os Indivíduos Apresentamunclassified

Prevalência de sintomas otoneurológicos em indivíduos com hipotireoidismo congênito: estudo piloto

et al. 2017

View full text Add to dashboard Cite

Resumo Objetivo Investigar a frequência de sintomas otoneurológicos em crianças com hipotireoidismo congênito e relacioná-los com os aspectos clínicos. Métodos Estudo exploratório de caráter descritivo seccional. A casuística foi composta pelos pais e/ou cuidadores de 105 crianças com diagnóstico de hipotireoidismo congênito e com 5 anos ou mais de idade. A coleta de dados utilizou um questionário estruturado elaborado e testado pelos pesquisadores. As informações clínicas e laboratoriais foram obtidas dos prontuários médicos. Resultados A maioria dos indivíduos (72,4%) demonstrou sintomas relacionados à disfunção vestibulococlear, na qual a tontura/vertigem correspondeu a 56,2% dos sintomas, seguida pela hipoacusia (43,8%) e pelo zumbido (12,4%). Houve correlação estatística entre os sintomas de hipoacusia (p=0,016) e a idade para o teste de rastreio neonatal, bem como os sintomas de tontura/vertigem com a etiologia do hipotireoidismo congênito (p=0,003). Na percepção da hipoacusia (RP=0,49; IC=0,31-0,77), a exposição ao fator demonstrou associação com a probabilidade de 95%. Conclusão Os achados sugerem significativa prevalência e associação entre hipotireoidismo congênito e sintomas otoneurológicos, especialmente tontura, hipoacusia e zumbido.

show abstract

“…Cortical map plasticity is induced by deafferentation in not only the somatosensory but also the visual and auditory systems (Merzenich et al, 1983;Calford, 2002). Photophobia is observed in patients with optic nerve injury (Kawasaki and Purvin, 2002), and damage to the inner hair cells produces tinnitus (Saunders, 2007). These sensory abnormalities may be comparable with neuropathic pain in the somatosensory system.…”

Section: Basal Firing In Sensory Nervesmentioning

confidence: 99%

Initial Phase of Neuropathic Pain within a Few Hours after Nerve Injury in Mice

Komagata

Chen²,

Suzuki³

et al. 2011

J. Neurosci.

View full text Add to dashboard Cite

We tested a hypothesis that the spinal plasticity induced within a few hours after nerve injury may produce changes in cortical activities and an initial phase of neuropathic pain. Somatosensory cortical responses elicited by vibratory stimulation were visualized by transcranial flavoprotein fluorescence imaging in mice. These responses were reduced immediately after cutting the sensory nerves. However, the remaining cortical responses mediated by nearby nerves were potentiated within a few hours after nerve cutting. Nerve injury induces neuropathic pain. In the present study, mice exhibited tactile allodynia 1-2 weeks after nerve injury. Lesioning of the ipsilateral dorsal column, mediating tactile cortical responses, abolished somatic cortical responses to tactile stimuli. However, nontactile cortical responses appeared in response to the same tactile stimuli within a few hours after nerve injury, indicating that tactile allodynia was acutely initiated. We investigated the trigger mechanisms underlying the cortical changes. Endogenous glial cell line-derived neurotrophic factor (GDNF), found in the Meissner corpuscles, induced basal firing ϳ0.

show abstract

The role of central nervous system plasticity in tinnitus

Cited by 76 publications

References 80 publications

Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity

Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity

Prevalência de sintomas otoneurológicos em indivíduos com hipotireoidismo congênito: estudo piloto

Initial Phase of Neuropathic Pain within a Few Hours after Nerve Injury in Mice

Contact Info

Product

Resources

About