The role of cagA Helicobacter pylori strains in gastro-oesophageal reflux disease

Pereira-Lima, Júlio Carlos; Marques, Daniela Lemos; Pereira-Lima, Luiz; Hornos, Alexander Porley; Rota, C.

doi:10.1097/01.meg.0000108340.41221.9e

Cited by 10 publications

(7 citation statements)

References 32 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although this did not reach statistical significance, perhaps secondary to small sample size, this questions whether CagA− strains of H. pylori are more likely to colonize or infect the gallbladder–biliary tract. This is particularly interesting as the cagA genotype is thought to protect against more severe forms of GORD, including the complication of Barrett's oesophagus 21,22 . This observation supports our hypothesis that benign gallbladder disease may be associated with GORD and gastritis, and it may involve infection with CagA− strains of H. pylori.…”

Section: Discussionsupporting

confidence: 82%

Identification of Helicobacter spp. in bile and gallbladder tissue of patients with symptomatic gallbladder disease

Sabbaghian

Ranaudo

Zeng

et al. 2010

HPB

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 82%

Identification of Helicobacter spp. in bile and gallbladder tissue of patients with symptomatic gallbladder disease

Sabbaghian

Ranaudo

Zeng

et al. 2010

HPB

View full text Add to dashboard Cite

show abstract

“…We found that persons infected with a cagA-positive H. pylori strain were less likely than persons infected with a cagAnegative H. pylori strain to have a diagnosis of esophagitis upon endoscopic evaluation. Although it is not universal, many other researchers have seen this same relationship, suggesting a protective role for cagA-positive strains of H. pylori (25,37). Persons infected with H. pylori isolates having the vacA s1m1 genotype were also less likely to have an esophagitis diagnosis than those infected with an isolate having either the vacA s1m2 or s2m2 genotype.…”

Section: Discussionmentioning

confidence: 86%

Characterization of Helicobacter pylori cagA andvacAGenotypes among Alaskans and Their Correlation with Clinical Disease

et al. 2011

View full text Add to dashboard Cite

Helicobacter pylori infection is common in Alaska. The development of severe H. pylori disease is partially determined by the virulence of the infecting strain. Here we present vacA and cagA genotype data for H. pylori strains isolated from Alaskans and their correlation with clinical disease. We enrolled patients scheduled for esophagogastroduodenoscopy and positive for H. pylori infection. Gastric biopsy specimens from the stomach antrum and fundus were cultured. We performed PCR analysis of the H. pylori vacA gene and for the presence of the cagA gene and cagA empty site. We genotyped 515 H. pylori samples from 220 Native and 66 non-Native Alaskans. We detected the cagA gene in 242/286 (85%) persons; of 222 strains that could be subtyped, 95% (212) were non-Asian cagA and 3% (6) were East Asian cagA. After removing mixed infections (n ‫؍‬ 17), 83% of H. pylori strains had either the vacA s1m1 (120/269) or s2m2 (103/269) genotype. Sixty-six percent (68/103) of H. pylori strains with the vacA s2m2 genotype also contained the cagA gene. Infection with an H. pylori strain having the cagA gene or vacA s1m1 genotype (compared with s1m2 and s2m2) was associated with a decreased risk of esophagitis (P ‫؍‬ 0.003 and 0.0003, respectively). Infection with an H. pylori strain having the vacA s1m1 genotype (compared with s1m2 and s2m2) was associated with an increased risk of peptic ulcer disease (PUD) (P ‫؍‬ 0.003). The majority of H. pylori strains in this study carried the non-Asian cagA gene and either the vacA s1m1 or s2m2 genotype. A majority of H. pylori strains with the vacA s2m2 genotype also contained the cagA gene. There was an association of H. pylori genotype with esophagitis and PUD.

show abstract

“…An adult study from Germany showed similar rates of infection with CagA-positive HP strains in patients with or without GERD, whereas the HP infection rate was significantly decreased in patients with Barrett's esophagus. 41 Pereira-Lima et al 42 also showed that the HP colonization rate did not differ between GERD-positive and -negative adults in Brazil. However, infection with CagA-positive HP strains seemed to prevent severe forms of GERD disease.…”

Section: Discussionmentioning

confidence: 93%

CagA positivity and its association with gastroduodenal disease in Turkish children undergoing endoscopic investigation

et al. 2006

View full text Add to dashboard Cite

show abstract

The role of cagA Helicobacter pylori strains in gastro-oesophageal reflux disease

Abstract: Infection of the stomach by H. pylori and especially by H. pylori cagA strains may play a protective role against the development of the most severe forms of gastro-oesophageal reflux disease.

Cited by 10 publications

References 32 publications

Identification of Helicobacter spp. in bile and gallbladder tissue of patients with symptomatic gallbladder disease

Identification of Helicobacter spp. in bile and gallbladder tissue of patients with symptomatic gallbladder disease

Characterization of Helicobacter pylori cagA andvacAGenotypes among Alaskans and Their Correlation with Clinical Disease

CagA positivity and its association with gastroduodenal disease in Turkish children undergoing endoscopic investigation

Contact Info

Product

Resources

About