The role of C-reactive protein as a diagnostic predictor of sepsis in a multidisciplinary Intensive Care Unit of a tertiary care center in Nepal

Pradhan, Saurabh; Ghimire, A; Bhattarai, Balkrishna; Khanal, Bhawani; Pokharel, Krishna; Lamsal, Madhab; Koirala, Sidhhartha

doi:10.4103/0972-5229.186226

Cited by 41 publications

(39 citation statements)

References 13 publications

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“…The role of CRP in sepsis has been reported in multidisciplinary studies on patients in the ICU setting (34,35). The present study reported that the serum levels of HMGB1 and CRP were significantly increased in sepsis patients compared with those in healthy individuals.…”

Section: Discussionsupporting

confidence: 66%

Inflammatory cytokine expression in patients with sepsis at an intensive care unit

2018

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Abstract. Sepsis is a systemic inflammatory response syndrome caused by infection of bacteria, fungi and/or viruses in clinical patients. It is known that inflammatory cytokine levels have an essential role in the progression of sepsis. The present study investigated the role of inflammatory markers in human peripheral blood mononuclear cells (hPBMCs) of patients with sepsis at an intensive care unit. In addition, the plasma levels of inflammatory cytokines were compared between sepsis patients and healthy individuals. The results demonstrated that the serum levels of interleukin-1, -17 and -6, as well as tumor necrosis factor-α, were upregulated in sepsis patients. The serum levels of high mobility group box 1 and C-reactive protein were increased in sepsis patients compared with those in healthy individuals. The expression levels of nuclear factor-κB-p65 and its inhibitor IκBα, as well as the ratio of CD25 + cells, and the levels of neutrophil gelatinase-associated lipocalin and peptidoglycan recognition protein were higher in hPBMCs in sepsis patients compared with those in healthy individuals. It was also indicated that balance of T helper type 1/2 cytokines was also disturbed in patients with sepsis compared with that in healthy individuals. In conclusion, these results indicated that inflammation is involved in the progression of sepsis by interfering with the expression of various molecules, suggesting a potential therapeutic strategy for the treatment of sepsis patients.

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Section: Discussionsupporting

confidence: 66%

Inflammatory cytokine expression in patients with sepsis at an intensive care unit

2018

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“…Pradhan et al emphasised that CRP is useful in identifying patients with sepsis diagnosed with SIRS. In addition, they stated that CRP could be a very useful marker in resourcerestricted areas where sepsis specialists are not available and especially in places where data on procalcitonin or interleukins are not accessible [33]. In our study, although there was no difference between mortal and nonmortal cases diagnosed with sepsis, this does not minimise the fact that CRP may be beneficial in the diagnosis of sepsis, although it is not predictive for all aspects of the condition.…”

Section: Discussioncontrasting

confidence: 53%

Statistical analysis of the relationship between mortality and nosocomial factors in patients with septicemia and the importance of Pseudomonas aeruginosa

Dülger¹

2020

Turk J Vet Anim Sci

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The ongoing evolution of sepsis as a condition constitutes a global health concern and necessitates continuous monitoring and investigation of incidence rates, mortality factors, and disease patterns. This study sought to elucidate the frequency of bacterial cultures in patients with septicemia at our hospital and identify the factors influencing mortality. Zoonotic risk factors with reference to the literature were also taken into account.Independent variables of all patients diagnosed with sepsis were retrospectively screened to reveal factors affecting mortality. Incomplete or unclear data were not included. Continuous variables are represented as means and standard deviations, whereas binary variables are represented as percentages and frequency values. The distribution was evaluated using the Kolmogorov-Smirnov test. Separately, the Student's t-test or Mann-Whitney U test was used to compare differences for continuous variables between independent groups according to distribution status. Dichotomous variables were evaluated using the chi-squared or Fisher's exact test. Significant results found during univariate analysis were reevaluated using linear and binary logistic regression. Neither the length of hospital stay nor patient age was statistically significant, for mortality. Among dichotomous variables, sex also did not impact the mortality rate. Meanwhile, Salmonella, Shigella, and Pseudomonas aeruginosa infections were found to cause mortality. During the final statistical analysis using multiple logistic regression, only P. aeruginosa was a factor influencing the mortality rate. P. aeruginosa is an important pathogen that contributes to increased risks of mortality and zoonotic transmission among patients with sepsis.

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“…Interleukin-6 (IL-6) and its downstream product, CRP, are therefore both well-known inflammatory molecules. Importantly, due to an increase in IL-6, circulaitng CRP levels can increase up to 1000 times during disease or inflammation [25]. We also included analysis of levels of HbA1c and lipid profiles, as these are markers that can confirm hyperglycemia and systemic inflammation.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation

Randeria

Thomson

Nell

et al. 2019

Cardiovasc Diabetol

120

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Background: The global burden of type 2 diabetes mellitus (T2DM), together with the presence of cardiovascular risk in this population, is reaching pandemic levels. A prominent feature of T2DM is chronic and systemic inflammation, with the accompanying presence of circulating and dysregulated inflammatory biomarkers; which in turn is associated with abnormal clot formation. Methods:Here, we investigate the correlation between abnormal blood clotting, using thromboelastography (TEG), clot ultrastructure using scanning electron microscopy (SEM) and the presence of a dysregulated inflammatory cytokine profile, by examining various circulating biomarkers. Results:Our results show that many biomarkers, across TEG, cytokine and lipid groups, were greatly dysregulated in the T2DM sample. Furthermore, our T2DM sample's coagulation profiles were significantly more hypercoagulable when compared to our heathy sample, and ultrastructural analysis confirmed a matted and denser clot structure in the T2DM sample. Conclusions:We suggest that dysregulated circulating molecules may in part be responsible for a hypercoagulable state and vascular dysfunction in the T2DM sample. We propose further that a personalized approach could be of great value when planning treatment and tracking the patient health status after embarking on a treatment regimes, and that looking to novel inflammatory and vascular biomarkers might be crucial.

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The role of C-reactive protein as a diagnostic predictor of sepsis in a multidisciplinary Intensive Care Unit of a tertiary care center in Nepal

Cited by 41 publications

References 13 publications

Inflammatory cytokine expression in patients with sepsis at an intensive care unit

Inflammatory cytokine expression in patients with sepsis at an intensive care unit

Statistical analysis of the relationship between mortality and nosocomial factors in patients with septicemia and the importance of Pseudomonas aeruginosa

Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation

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