The role of bioreactors in tissue engineering

Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays

“…An ex vivo tissue array could have tremendous impact on biotechnology, such as the development of functional tissue engineering (Martin et al, 2004). The fluidic control and continuous perfusion provided by the microfluidic cell culture array may create a more ''tissue-friendly'' microenvironment than traditional culture methods.…”

Nanotechnology in regenerative medicine: the materials side

“…pH, temperature, pressure, fluidic and mechanical environment, nutrient supply and waste control). These devices integrate several types of BioMEMS into a single device to optimise tissue regeneration and to provide specific conditions for large-scale industrial applications [45]. Biosensors and laboratory-on-a-chip are integrated inside bioreactors to monitor and detect specific cellular processes ( Figure 3).…”

The influence of hydrostatic pressure on tissue engineered bone development

“…In developing the models presented in this paper, we have ignored spatial effects, assumed the system is well nourished and focused on the temporal response to applied pressure. As such we have neglected the effects of nutrient-limited growth and shear-stress mediated responses, which may also be influential in the quantity of minerals deposited (Martin, 2004;McCoy and O'Brien, 2010;Yeatts and Fisher, 2011;Riddle and Donahue, 2009;Leonard, 2014).…”

“…In vitro tissue engineering is a method for creating functional tissue and organ samples external to the body, with the aim of replacing damaged or diseased tissues and organs (Rose and Oreffo, 2002;Martin, 2004). Our particular focus is on bone tissue engineering.…”