The Role of Allium Sativum (Garlic) in Various Diseases and Its Health Benefits: A Comprehensive Review.

Divya, B S; Suman, B. C.; kumar, LLakshman; Venkataswamy, M.; Eswari, B; Thyagaraju, K.

doi:10.21474/ijar01/5094

Cited by 13 publications

(20 citation statements)

References 35 publications

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“…It exhibits medicinal properties including, antibacterial, antioxidant, immunomodulation, antimutagenic, and anticarcinogenic effects [47]. Also, it has been claimed to be effective against a number of diseases [45] [48] [49]. Allium sativum contains several enzymes, at least 33 sulfur compounds, and the minerals calcium, germanium, iron, copper, selenium, magnesium, potassium, and zinc; vitamins A, B1, and C, fiber, and water.…”

Section: Garlic (Allium Sativum)mentioning

confidence: 99%

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Azab¹,

Albasha²,

Elsayed³

2017

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Nephrotoxicity is one of the most common kidney problems and occurs when the body is exposed to a drug or toxin. Natural sources of antioxidants may serve as a vital source of potentially useful new compounds for the development of an effective therapy to combat a variety of kidney problems. Natural antioxidants have a variety of biochemical actions such as inhibition of reactive oxygen species production, scavenging of free radicals. The present review aims to summarize the recent articles which studied some of the nephrotoxic agents, and alleviation of nephrotoxicity using of some natural products possessing antioxidant properties. Our review shows the oxidative damage and renal disorders induced in human and experimental animals by nephrotoxic agents such as gentamicin, alcohol, nicotine, adenine, glycerol, ethylene glycol, sodium nitrite, mercuric chloride, AlCl 3 , lead acetate, carbon tetrachloride (CCl 4 ), furosemide, carbendazim, diazinon, heat stress, and γ-radiation. Also, nephrotic disorders caused in diabetic rats, patients, cirrhotic ascetic patients, and ischemia-reperfusion. Administration of natural sources of antioxidants such as curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame attenuated both physiological and histopathological alterations induced in the kidney by the nephrotoxic agent and certain diseases. The nephroprotective effect of the former natural sources of antioxidants may be due to the enhancement of antioxidant activity and inhibition of tissue lipid peroxidation. It can be concluded that administration of curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame showed a remarkable kidney protection against nephrotoxic agents, and diseases induced renal dysfunctions in human and experimental animals. So, the present study recommended that the consumption of these natural sources of antioxidants may be useful for human exposure to nephrotoxic agents and patients who suffer from renal diseases.

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Section: Garlic (Allium Sativum)mentioning

confidence: 99%

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Azab¹,

Albasha²,

Elsayed³

2017

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“…Garlic has more than 500 species in 30 genera (13), a good source of anti-oxidants and contains at least 33 sulfur compounds, several enzymes, vitamin B, flavonoids and certain minerals (33). Garlic contains 17 amino acids e.i.…”

Section: Chemical Constituents Of Garlicmentioning

confidence: 99%

Garlic the Wonder Adjuvant in Medicinal Field

Saharan

Pal

Sachdeva

et al. 2023

Experimental and Applied Biomedical Research (EABR)

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Background: Plant derived compounds are drawing attention in curing and treating variety of ailment and diseases. This increase in popularity of natural products has renewed interest in garlic, which has been used by human for centuries. It has been found that garlic pulp contains more than 200 chemical compounds and numerous garlic molecules can still be explored, extracted, synthesized and optimized. As in market various preparations of garlic are available which include tablets made from dried and powdered clove, oils and liquid extracts however, it would also be interesting to explore the effect of different forms of garlic extract on standard drug therapy especially when used as an adjuvant therapy. In this review a report on the pharmaceutical preparation which has used extracted compounds from garlic or its derivatives as a main constituent is compiled, so that it could be useful to increase our knowledge about the therapeutic effect of garlic and could improve our future experimental and chemical plans. Methods: We performed a systematic review of literature using term garlic. Result: In this report a comprehensive investigation has been conducted on garlic which includes various scientific aspects about it by which researchers from various disciplines could be directed to put efforts toward discovering the benefits of garlic on human health. Conclusion: Garlic and its extracts had a wide range of applications even against resistant organisms to serve as powerful anti-microbial agent. Therefore, research is needed to refine the pathophysiological mechanisms of action of garlic and its utility in treatment of various diseases by developing more stable and suitable formulations. The development of Garlic as a commercial anti-biotic has come to a halt. Although its efficiency is scientifically proven still it has only been used as dietary supplement or as traditional medicine.

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“…Garlic (Allium sativum L) is a herbal plant; besides its use as a food flavoring, garlic has another function as an antibacterial (antibiotic) containing allicin and alliin to prevent diseases. Garlic has 33 sulfur components, 17 amino acids, and some minerals and enzymes that make the smell characteristic of garlic medicines [8], where sulfur is one of the compounds most responsible for garlic taste aroma and pharmacological properties [9]. This plant also contains saponin and flavonoids that support anti-blood thrombotic, blood lipid, neuron pressure, antibacterial, and inhibitor of food pathogen.…”

Section: Introductionmentioning

confidence: 99%